Results 31 to 40 of about 8,226 (286)

Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors [PDF]

open access: yes, 2020
Detergents enable the purification of membrane proteins and are indispensable reagents instructural biology. Even though a large variety of detergents have been developed in the lastcentury, the challenge remains to identify guidelines that allowfine ...
Almeida, F.   +12 more
core   +2 more sources

Native-like membrane models of E. coli polar lipid extract shed light on the importance of lipid composition complexity

open access: yesBMC Biology, 2021
Background Lipid-protein interactions stabilize protein oligomers, shape their structure, and modulate their function. Whereas in vitro experiments already account for the functional importance of lipids by using natural lipid extracts, in silico methods
Kristyna Pluhackova, Andreas Horner
doaj   +1 more source

2357 Lost and found: Detection of brain cardiolipins in plasma after cardiac arrest

open access: yesJournal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: Neurological injury remains as the main limiting factor for overall recovery after cardiac arrest (CA). Currently available indicators of neurological injury are inadequate for early prognostication after return of spontaneous ...
Andrew M. Lamade   +9 more
doaj   +1 more source

Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli [PDF]

open access: yes, 2016
The outer membrane of gram-negative bacteria is composed of phospholipids in the inner leaflet and lipopolysaccharides (LPS) in the outer leaflet. LPS is an endotoxin that elicits a strong immune response from humans, and its biosynthesis is in part ...
Andrews, SS   +3 more
core   +1 more source

Defining functional classes of Barth syndrome mutation in humans [PDF]

open access: yes, 2016
The X-linked disease Barth syndrome (BTHS) is caused by mutations in TAZ; TAZ is the main determinant of the final acyl chain composition of the mitochondrial-specific phospholipid, cardiolipin.
Claypool, Steven M.   +12 more
core   +10 more sources

A Five-Year Update on Matrix Compounds for MALDI-MS Analysis of Lipids

open access: yesBiomolecules, 2023
Matrix-assisted laser desorption and ionization (MALDI) is a widely used soft-ionization technique of modern mass spectrometry (MS). MALDI enables the analysis of nearly all chemical compounds—including polar and apolar (phospho)lipids—with a minimum ...
Jenny Leopold   +3 more
doaj   +1 more source

Dietary macronutrients modulate the fatty acyl composition of rat liver mitochondrial cardiolipins[S]

open access: yesJournal of Lipid Research, 2013
The interaction of dietary fats and carbohydrates on liver mitochondria were examined in male FBNF1 rats fed 20 different low-fat isocaloric diets.
Irina G. Stavrovskaya   +7 more
doaj   +1 more source

Lipidomics in Health and Diseases - Beyond the Analysis of Lipids [PDF]

open access: yes, 2014
published_or_final_versio
Fan, P, Li, M, Wang, Y
core   +1 more source

Oxidative Stress Linked Organ Lipid Hydroperoxidation and Dysregulation in Mouse Model of Nonalcoholic Steatohepatitis: Revealed by Lipidomic Profiling of Liver and Kidney

open access: yesAntioxidants, 2021
Nonalcoholic steatohepatitis (NASH) is a prevalent disease related to lipid metabolism disorder and oxidative stress. Lipid hydroperoxidation is known to be a critical driving force of various disorders and diseases.
Yue Wu   +8 more
doaj   +1 more source

Osmotic shock stimulates de novo synthesis of two cardiolipins in an extreme halophilic archaeon

open access: yesJournal of Lipid Research, 2004
The present report illustrates the response to osmotic stress of an extreme halophilic archaeon, Halorubrum sp., isolated from the saltern ponds of Margherita di Savoia in southern Italy.
Patrizia Lopalco   +3 more
doaj   +1 more source

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