Results 81 to 90 of about 4,774 (217)

Mitochondrial membrane lipid remodeling in pathophysiology: A new target for diet and therapeutic interventions [PDF]

, 2013
Mitochondria are arbiters in the fragile balance between cell life and death. These organelles present an intricate membrane system, with a peculiar lipid composition and displaying transverse as well as lateral asymmetry.
Jurado, A. S., Monteiro, João P., Oliveira, Paulo J.   +2 more
core   +1 more source

A Refractory Leg Skin Ulcer Associated With Multiple Myeloma Successfully Treated With Plasma Exchange, Lenalidomide, and Dexamethasone

JEADV Clinical Practice, EarlyView.
ABSTRACT Multiple myeloma (MM) is a malignant plasma cell disorder that primarily presents with CRAB symptoms (calcium elevation, renal failure, anemia, and bone abnormalities). In rare cases, MM manifests with systemic complications like skin ulcers, which present management challenges. Here, we report a 78‐year‐old Japanese man with MM and refractory
Naoko Hattori, Yutaka Kuwatsuka, Tomoka Waseda, Daisuke Ehara, Koji Ando, Hiroyuki Murota   +5 more
wiley   +1 more source

Epithelial ovarian carcinoma diagnosis by desorption electrospray ionization mass spectrometry imaging [PDF]

, 2016
Ovarian cancer is highly prevalent among European women, and is the leading cause of gynaecological cancer death. Current histopathological diagnoses of tumour severity are based on interpretation of, for example, immunohistochemical staining. Desorption
Brown, R, Doria, ML, Ghaem-Maghami, S, Golf, O, McKenzie, JS, Mroz, A, Phelps, DL, Rosini, F, Speller, A, Strittmatter, N, Takats, Z, Veselkov, K   +11 more
core   +1 more source

ChitoSilkBioPatch: A bio‐inspired wound dressing scaffold for antibiotic‐free diabetic wound management

VIEW, EarlyView.
We present ChitoSilkBioPatch, a maleimide‐functionalized chitosan/dACM hydrogel integrated with a stretchable nanopatterned silk mesh to provide intrinsic, antibiotic‐free antibacterial activity and bioactive wound support. The scaffold eliminates S. aureus and P.
Dorsa Dehghan‐Baniani, Babak Mehrjou, Yucong Li, Zhaowei Jiang, Xiaomin Lu, Yin Xiao, Huanxiong Chen, Tsz Lam Yiu, Chi Chiu Wang, Hongkai Wu, Gang Li, Paul K. Chu, Wayne Yuk Wai Lee   +12 more
wiley   +1 more source

Subcellular organelle lipidomics in TLR-4-activated macrophages1[S]

Journal of Lipid Research, 2010
Lipids orchestrate biological processes by acting remotely as signaling molecules or locally as membrane components that modulate protein function. Detailed insight into lipid function requires knowledge of the subcellular localization of individual ...
Alexander Y. Andreyev, Eoin Fahy, Ziqiang Guan, Samuel Kelly, Xiang Li, Jeffrey G. McDonald, Stephen Milne, David Myers, Hyejung Park, Andrea Ryan, Bonne M. Thompson, Elaine Wang, Yihua Zhao, H. Alex Brown, Alfred H. Merrill, Christian R.H. Raetz, David W. Russell, Shankar Subramaniam, Edward A. Dennis   +18 more
doaj   +1 more source

Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease [PDF]

, 2019
The discovery of rare familial monogenic forms of early-onset Parkinson's disease has led to the identification of a mitochondrial quality control process as a key player in this disease.
Miller, Silke, Muqit, Miratul M. K.
core   +2 more sources

Neutron reflectometry instrumentation at the ISIS source: current state

Journal of Applied Crystallography, EarlyView.
This article presents the current capabilities of the four time‐of‐flight neutron reflectometers at the ISIS Neutron and Muon Source, highlighting recent advances in instrumentation, automation and data analysis that enable high‐precision studies of interfacial structures across diverse scientific fields.Neutron reflectometry (NR) at the ISIS Neutron ...
Mario Campana, Andrew Caruana, Luke Clifton, Stephen Hall, Arwel Hughes, Christy Kinane, Maximilian Skoda, Oleksandr Tomchuk, John Webster   +8 more
wiley   +1 more source

Dysfunctional copper homeostasis in Caenorhabditis elegans affects genomic and neuronal stability

Redox Biochemistry and Chemistry
While copper (Cu) is an essential trace element for biological systems due to its redox properties, excess levels may lead to adverse effects partly due to overproduction of reactive species. Thus, a tightly regulated Cu homeostasis is crucial for health.
Ann-Kathrin Weishaupt, Anna Gremme, Torben Meiners, Vera Schwantes, Karsten Sarnow, Alicia Thiel, Tanja Schwerdtle, Michael Aschner, Heiko Hayen, Julia Bornhorst   +9 more
doaj   +1 more source

Focal Targeting of the Bacterial Envelope by Antimicrobial Peptides

Frontiers in Cell and Developmental Biology, 2016
Antimicrobial peptides (AMPs) are utilized by both eukaryotic and prokaryotic organisms. AMPs such as the human beta defensins, human neutrophil peptides, human cathelicidin, and many bacterial bacteriocins are cationic and capable of binding to anionic ...
Rafi eRashid, Mark eVeleba, Kimberly A. Kline   +2 more
doaj   +1 more source

Влияние пальмитиновой кислоты на содержание кардиолипина и фосфатидной кислоты в изолированных гепатоцитах крыс [PDF]

, 2010
Cardiolipin and phosphatic acid contents in the hepatocytes, isolated from the liver of 3-month-old rats, under exposure to palmitic acid were investigated.
Babenko, N.A., Storozhenko, G.V., Бабенко, Н.А., Стороженко, Г.В.   +3 more
core