A Randomized, Placebo‐Controlled Trial of Hydroxychloroquine in Incomplete Lupus
Arthritis &Rheumatology, EarlyView.Objective Patients with features of systemic lupus erythematosus (SLE) who do not fulfill classification criteria can be designated as incomplete lupus erythematosus (ILE). This condition includes individuals with a high risk of progression to SLE. Treatment of ILE may reduce symptoms, severity, and incidence of SLE.
Nancy J. Olsen +14 more
wiley +1 more source
Biochemical and crystallographic studies of monomeric and dimeric bovine cytochrome c oxidase
Biophysics and Physicobiology, 2021 Cytochrome c oxidase (CcO), a terminal oxidase in the respiratory chain, catalyzes the reduction of O2 to water coupled with the proton pump across the membrane.
Kyoko Shinzawa-Itoh, Kazumasa Muramoto
doaj +1 more source
Epithelial ovarian carcinoma diagnosis by desorption electrospray ionization mass spectrometry imaging [PDF]
, 2016 Ovarian cancer is highly prevalent among European women, and is the leading cause of gynaecological cancer death. Current histopathological diagnoses of tumour severity are based on interpretation of, for example, immunohistochemical staining. Desorption
Brown, R +11 more
core +1 more source
Cardiolipins and biomembrane function [PDF]
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1992 Evidence is discussed for roles of cardiolipins in oxidative phosphorylation mechanisms that regulate State 4 respiration by returning ejected protons across and over bacterial and mitochondrial membrane phospholipids, and that regulate State 3 respiration through the relative contributions of proteins that transport protons, electrons and/or ...
openaire +3 more sources
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Lipids in Mitochondrial Macroautophagy: Phase Behavior of Bilayers Containing Cardiolipin and Ceramide [PDF]
, 2023 Yaiza R. Varela +7 more
openalex +1 more source
Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease [PDF]
, 2019 The discovery of rare familial monogenic forms of early-onset Parkinson's disease has led to the identification of a mitochondrial quality control process as a key player in this disease.
Miller, Silke, Muqit, Miratul M. K.
core +2 more sources
Subcellular organelle lipidomics in TLR-4-activated macrophages1[S]
Journal of Lipid Research, 2010 Lipids orchestrate biological processes by acting remotely as signaling molecules or locally as membrane components that modulate protein function. Detailed insight into lipid function requires knowledge of the subcellular localization of individual ...
Alexander Y. Andreyev +18 more
doaj +1 more source
Влияние пальмитиновой кислоты на содержание кардиолипина и фосфатидной кислоты в изолированных гепатоцитах крыс [PDF]
, 2010 Cardiolipin and phosphatic acid contents in the hepatocytes, isolated from the liver of 3-month-old rats, under exposure to palmitic acid were investigated.
Babenko, N.A. +3 more
core
iMetaOmics, EarlyView.First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang +9 more
wiley +1 more source