Results 91 to 100 of about 4,979,977 (315)

Molecular Mechanisms Underlying Cardiometabolic Disease in Aging [PDF]

, 2019
Aging is the main risk factor for developing cardiovascular and metabolic diseases, which have become a global concern as the world population is progressively aging.
Fanjul, Victor
core   +1 more source

Associations between consumption of three types of beverages and risk of cardiometabolic multimorbidity in UK Biobank participants: a prospective cohort study

BMC Medicine, 2022
Background Although the association between beverages and a single cardiometabolic disease has been well studied, their role in disease progression from the single cardiometabolic disease state to cardiometabolic multimorbidity (CMM) state remains ...
Yi Luo, Lingfang He, Tianqi Ma, Jinchen Li, Yongping Bai, Xunjie Cheng, Guogang Zhang   +6 more
doaj   +1 more source

Multi‐Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue‐ and Trait‐Specific Animal Model Selection

Advanced Science, EarlyView.
We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Jingwen Dou, Yong Liao, Xiong Shen, Xin Huang, Zhenshuang Tang, Yuwei Gou, Huajun Zhou, Jingya Xu, Hong Liu, Yue Wang, Keke Liang, Jia Liu, Xiao Zhang, Chenyao Li, Shangjian Wang, Liangliang Fu, Lilin Yin, Xinyun Li, Shuhong Zhao, Xiaolei Liu, Jingjin Li, Yuhua Fu   +21 more
wiley   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source

Cardiometabolic Disease in Human Immunodeficiency Virus-Infected Children

, 2008
Cardiometabolic problems in children with human immunodeficiency virus (HIV) infection have recently begun to emerge as distinct clinical problems that require monitoring and often intervention.
Steven E. Lipshultz, Grant, Yoran T, Almeida, Daniela Neri, Yoran T. Grant, Sharma, Tanvi, Tracie L. Miller, Miller, Tracie L, Daniela Neri Almeida, Tanvi Sharma, Lipshultz, Steven E   +9 more
core   +1 more source

Long-term cardiometabolic disease risk in women with PCOS:a systematic review and meta-analysis [PDF]

, 2020
BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with cardiometabolic disease, but recent systematic reviews and meta-analyses of longitudinal studies that quantify these associations are lacking.OBJECTIVE AND RATIONALE: Is PCOS a risk factor ...
Roeters van Lennep, J. E., van Lennep, J. E. Roeters, Laven, J. S. E., Heida, K. Y., Hoek, A., Wekker, V., van Dammen, L., Painter, R. C., Wekker, Vincent, Roseboom, T. J., Limpens, J., Koning, A.   +11 more
core   +2 more sources

Clinical, socioeconomic, and behavioural factors at age 50 years and risk of cardiometabolic multimorbidity and mortality: A cohort study.

PLoS Medicine, 2018
BackgroundMultimorbidity is increasingly common and is associated with adverse health outcomes, highlighting the need to broaden the single-disease framework that dominates medical research.
Archana Singh-Manoux, Aurore Fayosse, Séverine Sabia, Adam Tabak, Martin Shipley, Aline Dugravot, Mika Kivimäki   +6 more
doaj   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Overweight patterns throughout childhood and cardiometabolic markers in early adolescence [PDF]

, 2016
BACKGROUND: Risk of cardiovascular and metabolic disease is higher in adults who were relatively thin at birth and had subsequent accelerated weight gain.
dIRAS RA-2, Berentzen, N E, Wijga, A H, Berentzen, N. E., de Jongste, J. C., Wijga, AH, Gehring, U, Postma, DS, Wijga, A. H., Smit, H.A., Koppelman, G. H., Jongste, Johan, Gehring, U., Postma, D. S., Smit, H A, Berentzen, NE, Koppelman, GH, van Rossem, L., Koppelman, G. H.; id_orcid, Postma, D S, Smit, H. A., de Jongste, J C, LS IRAS EEPI ME (Milieu epidemiologie), van Rossem, L, Koppelman, G H, Smit, HA   +25 more
core   +3 more sources