Results 111 to 120 of about 147,725 (290)

Disability, Physical Inactivity, and Impaired Health-Related Quality of Life Are Not Different in Metabolically Healthy vs. Unhealthy Obese Subjects [PDF]

, 2016
BACKGROUND: Obesity represents a major health hazard, affecting morbidity, psychological status, physical functionality, quality of life, and mortality.
Donini, Lorenzo Maria, Gnessi, Lucio, Lenzi, Andrea, Lubrano, Carla, Mariani, Stefania, Merola, Gianluca, Migliaccio, Silvia, Poggiogalle, Eleonora   +7 more
core   +2 more sources

PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou, Estella S. Poloni, José A.G. Agúndez, Raquel L.F. Teixeira, Erin C. Boone, Adalberto Rezende Santos, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Mariam R. Habil, Giannoulis Fakis, Rodney F. Minchin, David W. Hein, Sotiria Boukouvala, Andrea Gaedigk   +14 more
wiley   +1 more source

Neighborhood Typology and Cardiometabolic Pregnancy Outcomes in the Maternal Adiposity Metabolism and Stress Study. [PDF]

, 2019
ObjectiveThis study aimed to assess associations between neighborhood typologies classified across multiple neighborhood domains and cardiometabolic pregnancy outcomes and determine variation in effectiveness of a mindfulness-based stress-reduction ...
Adler, Nancy, Coleman-Phox, Kimberly, Epel, Elissa, Headen, Irene, Laraia, Barbara, Vieten, Cassandra   +5 more
core   +1 more source

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

Elevated risk of recurrent stroke in females after patent foramen ovale closure for cryptogenic stroke:A 4-year retrospective cohort study

陆军军医大学学报
Objective To investigate the effect of gender on prognosis after transcatheter patent foramen ovale (PFO) closure in patients with cerebral infarction or transient ischemic attack.
XIAO Weiwei, XIAO Weiwei, LIU Feng, LIU Feng   +3 more
doaj   +1 more source

Occupational Physical Activity and Cardiovascular Risk Factors Profile in the Adult Population of the Southern Cone of Latin America: Results From the CESCAS I Study [PDF]

, 2018
OBJECTIVE: We explore the association between occupational physical activity (OPA) and cardiovascular risk factors in four cities of the Southern Cone. METHODS: Robust multivariable linear regression models were used to examine the associations. RESULTS:
Elorriaga, Natalia, Gutierrez, Laura, Irazola, Vilma, Melendi, Santiago Ezequiel, Poggio, Rosana   +4 more
core   +1 more source

Development of Disordered Weight Control Behaviors and Its Progression to Eating Disorders in Canada: A Nationally Representative Microsimulation

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (ED) present a significant health burden to children, adolescents, and young adults globally. Despite the importance of disordered weight control behaviors (DWCB) in ED development, little is known about the progression from DWCB to ED.
Ye Shen, Ariel L. Beccia, Nicolas A. Menzies, Chloe Gao, S. Bryn Austin, Amanda Raffoul   +5 more
wiley   +1 more source

Air pollutants, road traffic noise, and incidence of valvular heart disease: A UK Biobank-based prospective study

Ecotoxicology and Environmental Safety
Air and noise pollution are recognized public health concerns. However, their long-term impact on valvular heart disease (VHD) remains unclear. This study analyzed 453,413 participants from the UK Biobank.
Yanjun Song, Zhangyu Lin, Zhen’ge Chang, Jining He, Zhihao Zheng, Shanshan Shi, Bowen Li, Chen Zhu, Rui Fu, Kefei Dou   +9 more
doaj   +1 more source

Differences in physical activity time-use composition associated with cardiometabolic risks [PDF]

, 2019
This study investigates the association between the overall physical activity composition of the day (sedentary behavior (SB), light intensity physical activity (LIPA) and moderate-to-vigorous physical activity (MVPA)) and cardiometabolic health, and ...
Chastin, S.F.M., Dall, P.M., McGregor, D. E., Palarea-Albaladejo, J., Stamatakis, E.   +4 more
core   +3 more sources

Comprehensive exploration of unexplained dyspnoea in subjects with normal ejection fraction and low natriuretic peptides

ESC Heart Failure, Volume 12, Issue 2, Page 879-887, April 2025.
Abstract Background Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF). Aims This study aimed to characterize patients with exertional dyspnoea and normal/near‐to‐normal N‐terminal pro‐brain natriuretic peptide (NT ...
Emmanuelle Berthelot, Tarek Laouar, Antoine Beurnier, Nataliya Hrynchynshyn, Jean Christophe Eicher, Jean‐Michel Tartière, Patrick Jourdain, Olivier Lairez, Barnabas Gellen   +8 more
wiley   +1 more source