Results 121 to 130 of about 4,979,977 (315)

Incident low‐dose quetiapine use in adults newly diagnosed with depression in primary care: A nationwide register‐based study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to investigate the incidence of low‐dose quetiapine initiation and associated factors in adults newly diagnosed with depression in primary care. Methods We obtained medication dispensing records, primary and secondary care diagnoses and employment status for antipsychotic‐naïve individuals aged 16–65 newly diagnosed with ...
Laura Purra, Heidi Taipale, Miia Tiihonen, Markku Lähteenvuo, Jari Tiihonen, Aleksi Hamina   +5 more
wiley   +1 more source

Family history of myocardial infarction, stroke and diabetes and cardiometabolic markers in children [PDF]

, 2016
AIMS/HYPOTHESIS: Despite the overlap in occurrence of cardiovascular disease (CVD) and type 2 diabetes and their risk factors, family history of these diseases has not yet been investigated simultaneously in relation to cardiometabolic markers in ...
Spijkerman, Annemieke M W, Koppelman, Gerard H., dIRAS RA-2, Smit, Henriëtte A, Berentzen, Nina E, Spijkerman, Annemieke M. W., Koppelman, Gerard H.; id_orcid, van Rossem, Lenie, Wijga, Alet H, Koppelman, Gerard H, Gehring, Ulrike, Smit, Henriette A., LS IRAS EEPI ME (Milieu epidemiologie), Wijga, Alet H., van Nieuwenhuizen, Bo, Berentzen, Nina E.   +15 more
core   +3 more sources

Economic evaluations of antiobesity medications: A systematic literature review

British Journal of Clinical Pharmacology, EarlyView.
The global prevalence of obesity is rising rapidly. With several antiobesity medications approved and many more in development, understanding their economic value is increasingly important. This study reviews full economic evaluations of approved antiobesity medications to assess cost‐effectiveness and inform reimbursement and access decisions.
Martina Jurković, Almir Fajkić, Andrea Katrin Faour, Mirna Momčilović, Petra Turčić, Andrej Belančić   +5 more
wiley   +1 more source

Lithium‐related adverse drug reactions in children: A case–control study comparing lithium to second‐generation antipsychotics in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to improve the understanding of lithium's safety profile by analysing the frequency and distribution of reported adverse drug reactions (ADRs) compared to second‐generation antipsychotics (SGAs). Methods Individual case safety reports from VigiBase (1968–October 2023) involving individuals older than 2 years, with lithium or SGAs ...
Lisa T. Ringeling, Ravish N. Gangapersad, Lillian Lieuw, Patrick C. Souverein, Eibert R. Heerdink, Pilar Garcia‐Gomez, Manon H. J. Hillegers, Birgit C. P. Koch, Bram Dierckx   +8 more
wiley   +1 more source

The pro-tumorigenic roles of granzyme B: mechanisms and therapeutic implications

Frontiers in Immunology
Granzyme B (GZMB) is an effector molecule primarily expressed by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Historically, GZMB expression levels have served as a marker of immune activity, indicative of the potency of anti-tumor ...
Yubi Zhang, Yubi Zhang, Han Huang, Han Huang, Linjun Xie, Linjun Xie, Chunhong Li, Xiangyu Zhou, Xiangyu Zhou   +8 more
doaj   +1 more source

Baseline Body Mass Index Category and Incident Treated Hypertension in Australian Men: A Linked Prospective Cohort Study Using PBS/MBS Data

Chronic Diseases and Translational Medicine, EarlyView.
Kaplan–Meier hypertension‐free survival by baseline body mass index category, primary adult cohort (men aged ≥ 18 years, n = 12,742). Time since baseline in years is plotted on the horizontal axis and the probability of remaining free of treated hypertension is plotted on the vertical axis. Numbers at risk are shown beneath the plot.
Ebenezer Afrifa‐Yamoah
wiley   +1 more source

Comorbidities and Cardiometabolic Disease

JACC: Heart Failure, 2018
This study sought to evaluate the course, correlates, and prognosis of longitudinal changes in left ventricular (LV) diastolic dysfunction (DD) in the community-based Framingham Heart Study.Relationships of clinical risk factors to longitudinal progression of DD are incompletely understood.Diastolic function was assessed by echocardiography performed ...
Matthew, Nayor, Danielle M, Enserro, Vanessa, Xanthakis, Martin G, Larson, Emelia J, Benjamin, Jayashri, Aragam, Gary F, Mitchell, Ramachandran S, Vasan   +7 more
openaire   +2 more sources

Systemic Diseases and the Eye: A Translational Perspective on Diabetes

Chronic Diseases and Translational Medicine, EarlyView.
The eye–brain–cardiometabolic axis in diabetes: retinal biomarkers as indicators of systemic disease. ABSTRACT Diabetes mellitus is a global chronic disease that affects the whole body and not just glucose metabolism. In diabetes, non‐invasive ocular changes can help understand microvascular, neurodegenerative, and inflammatory processes. This analysis
Matteo Capobianco, Marco Zeppieri, Simonetta Gaia Nicolosi, Niccolò Castellino, Francesco Cappellani, Irene Gattazzo, Caterina Gagliano   +6 more
wiley   +1 more source

Mucosal-associated invariant T (MAIT) cells are depleted and prone to apoptosis in cardiometabolic disorders

, 2018
International audienceThe disruption of systemic immune homeostasis is a key mediator in the progression of cardiometabolic diseases (CMDs). We aimed to extend knowledge regarding the clinical relevance of CMD-associated variation of circulating mucosal ...
Marquet, Florian, MetaCardis Consortium, Clément, Karine, Helft, Gérard, Magali Fradet, Rouault, Christine, Assmann, Karen, Poitou, Christine, Aron-Wisnewsky, Judith, Karen E. Assmann, Sothea Touch, Consortium, Metacardis, André, Sébastien, Agnes Lehuen, Isnard, Richard, Mosbah, Héléna, Richard Isnard, Gerard Helft, Karine Clément, Christine Rouault, Touch, Sothea, Helena Mosbah, Florian Marquet, Lehuen, Agnès, Sébastien André, Fradet, Magali, Christine Poitou, Judith Aron-Wisnewsky   +27 more
core   +1 more source

Trust, but Verify: Translating Dosing Evidence to Understudied Populations in Low‐ and Middle‐Income Countries

Clinical Pharmacology &Therapeutics, EarlyView.
Drug dosing recommendations derived from healthy volunteers and selected preregistration populations may not translate reliably to physiologically distinct or understudied groups, particularly in low‐ and middle‐income countries. Using a metformin–dolutegravir drug interaction study and colistin pharmacokinetic study from South Africa, we illustrate ...
Roland van Rensburg, Veshni Pillay‐Fuentes Lorente, Eric Decloedt   +2 more
wiley   +1 more source