Results 21 to 30 of about 147,725 (290)

Associations between cardiorespiratory fitness, physical activity and clustered cardiometabolic risk in children and adolescents: the HAPPY study [PDF]

, 2012
Clustering of cardiometabolic risk factors can occur during childhood and predisposes individuals to cardiometabolic disease. This study calculated clustered cardiometabolic risk in 100 children and adolescents aged 10-14 years (59 girls) and explored ...
A Moran, AS Gami, AS Kelly, AV Rowlands, AV Rowlands, B Gutin, B Gutin, C Boreham, C Bouchard, C Mattocks, C Riddoch, Catherine J. Kerr, D Martinez-Gomez, Daniel P. Bailey, F Abbasi, G Baquet, G Stratton, GQ Shaibi, GS Berenson, HC McGill Jr, HD McCarthy, I Graham, IM Lee, JA Hawley, JR Ruiz, JR Ruiz, JV Freeman, JW Twisk, JW Twisk, K Patrick, L Aires, LM Boddy, Louise A. Savory, Lynne M. Boddy, MK Holten, MS Mitchell, ND Ridgers, P Parikh, P Zimmet, S Brage, SA Anderssen, Sarah J. Denton, SH Golden, SJ Fairclough, SM Camhi, SN Blair, T Shemesh, TJ Cole, TS Hannon, U Ekelund, U Ekelund, W Chen   +51 more
core   +2 more sources

Alzheimer disease genetic risk factor APOE e4, and cognitive abilities in 111,739 UK Biobank participants [PDF]

, 2016
Background: the apolipoprotein (APOE) e4 locus is a genetic risk factor for dementia. Carriers of the e4 allele may be more vulnerable to conditions that are independent risk factors for cognitive decline, such as cardiometabolic diseases.
Anderson, Jana, Bailey, Mark E.S., Celis, Carlos, Cullen, Breda, Davies, Gail, Deary, Ian J., Evans, Jon, Lyall, Donald M., Mackay, Daniel, McIntosh, Andrew M., Pell, Jill P., Ritchie, Stuart J., Sattar, Naveed, Smith, Daniel J., Ward, Joey   +14 more
core   +1 more source

Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey[S]

Journal of Lipid Research, 2016
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription factors SREBP-1 and -2.
Kristian K. Jensen, Marija Tadin-Strapps, Sheng-ping Wang, James Hubert, Yanqing Kan, Yong Ma, David G. McLaren, Stephen F. Previs, Kithsiri B. Herath, Ablatt Mahsut, Andy Liaw, Shubing Wang, Steven J. Stout, CarolAnn Keohan, Gail Forrest, David Coelho, Satya Yendluri, Stephanie Williams, Martin Koser, Steven Bartz, Karen O. Akinsanya, Shirly Pinto   +21 more
doaj   +1 more source

The association between cardiorespiratory fitness and cardiometabolic risk in children is mediated by abdominal adiposity: the HAPPY study [PDF]

, 2014
Background: It is unclear whether cardiorespiratory fitness (CRF) is independently linked to cardiometabolic risk in children. This study investigated a) the association between CRF level and presence of cardiometabolic risk disorders using health ...
Bailey, Daniel Paul, Denton, Sarah J., Kerr, Catherine J., Savory, Louise A.   +3 more
core   +2 more sources

Cardiometabolic diseases.

Revista brasileira de epidemiologia = Brazilian journal of epidemiology, 2019
Cardiometabolic diseases are prevalent in populations and are among the leading causes of death. Objective: This sub-study of the Health, Well-being and Aging (SABE) study describes the self-reported prevalence of diabetes mellitus (DM), hypertension, and atherosclerotic cardiovascular disease (CVD) for its three waves (2000, 2006, and 2010).
Sandra Roberta Gouvea, Ferreira, Alexandre Dias Porto, Chiavegatto Filho, Maria Lúcia, Lebrão, Yeda Aparecida de Oliveira, Duarte, Ruy, Laurenti   +4 more
openaire   +2 more sources

Lipids Metabolism and Cardiometabolic Diseases

International Journal of Molecular Sciences, 2023
Cardiometabolic diseases (CMD) remains the major cause of morbidity and mortality in Western countries, with a marked increased in the last years [...]
Melania Gaggini, Cristina Vassalle
openaire   +3 more sources

Synergistic effect of the commonest residual risk factors, remnant cholesterol, lipoprotein(a), and inflammation, on prognosis of statin-treated patients with chronic coronary syndrome

Journal of Translational Medicine, 2022
Background Currently, remnant cholesterol (RC), lipoprotein(a) [Lp(a)], and inflammation are considered the principal residual cardiovascular risk (RCVR) factors.
Hui-Hui Liu, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Rui-Xia Xu, Qian Dong, Jie Qian, Ke-Fei Dou, Jian-Jun Li   +9 more
doaj   +1 more source

Incidence of components of metabolic syndrome in the metabolically healthy obese over 9 years follow-up: the Atherosclerosis Risk In Communities study. [PDF]

, 2017
BackgroundSome obese adults are not afflicted by the metabolic abnormalities often associated with obesity (the 'metabolically healthy obese' (MHO)); however, they may be at increased risk of developing cardiometabolic abnormalities in the future. Little
Bradshaw, PT, Ndumele, CE, Reynolds, KR, Stevens, J, Wagenknecht, LE   +4 more
core   +2 more sources

Epigenetic processing in cardiometabolic disease [PDF]

Atherosclerosis, 2019
Albeit a consistent body of evidence supports the notion that genes influence cardiometabolic features and outcomes, the "non-genetic regulation" of this process is gaining increasing attention. Plastic chemical changes of DNA/histone complexes - known as epigenetic changes - critically determine gene activity by rapidly modifying chromatin ...
Costantino, Sarah, Mohammed, Shafeeq A, Ambrosini, Samuele, Paneni, Francesco   +3 more
openaire   +3 more sources

Comprehensive Care Models for Cardiometabolic Disease [PDF]

Current Cardiology Reports, 2021
The high burden of cardiovascular disease and the simultaneous obesity pandemic is placing an extraordinary strain on the health care system. In the current siloed care model, patients with cardiometabolic disease receive only fractionated care from multiple specialists, leading to insufficient treatment, higher costs, and worse outcomes.The imminent ...
Reiter-Brennan, Cara, Dzaye, Omar, Davis, Dorothy, Blaha, Mike, Eckel, Robert H.   +4 more
openaire   +2 more sources