Results 31 to 40 of about 123,173 (290)

Development of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic

mAbs, 2022
An in-house antibody generation campaign identified a diverse, high affinity set of anti-interleukin-11 (IL-11) monoclonal antibodies (mAbs) to enable successful development of novel, custom ultra-sensitive target engagement assays for detection of “free”
Maria Myzithras, Siqi Lin, Legairre Radden, Cynthia Hess Kenny, Zheng Cai, Angus MacDonald, Ralph Binetti, Michael Marlow, Paul Fracasso, Glenn Gibson, Christina Bartlett, Julie Hawkins, Steven Hansel   +12 more
doaj   +1 more source

CaMKII in Cardiometabolic Disease

Aging, 2014
The worldwide epidemic of obesity is closely linked to insulin resistance and type 2 diabetes (T2D), which have led to a critical need for new drug development. Insulin resistance and T2D contribute to the pathogenesis of many diseases including fatty liver disease, cardiovascular disease, kidney failure and retinal disease.
Lale, Ozcan, Ira, Tabas
openaire   +2 more sources

Hypertension and cardiometabolic disease

Frontiers in Bioscience, 2018
Hypertension has  a central role in cardiometabolic disease and is usually associated with  metabolic disorders, such as insulin resistance, obesity, and dyslipidemia. Hyperinsulinemia may increase cardiovascular (CV) risk through its promotion of hypertension, which is possibly a result of chronic enhancement of sympathetic nervous system activity ...
Ivan, Tasic, Dragan, Lovic
openaire   +2 more sources

HbA1c-based rather than fasting plasma glucose-based definitions of prediabetes identifies high-risk patients with angiographic coronary intermediate lesions: a prospective cohort study

Cardiovascular Diabetology, 2023
Background Prediabetes is common and associated with poor prognosis in patients with acute coronary syndrome and those undergoing revascularization. However, the impact of prediabetes on prognosis in patients with coronary intermediate lesions remains ...
Chenxi Song, Sheng Yuan, Kongyong Cui, Zhongxing Cai, Rui Zhang, Jining He, Zheng Qiao, Xiaohui Bian, Shaoyu Wu, Haoyu Wang, Boqun Shi, Zhangyu Lin, Rui Fu, Chunyue Wang, Qianqian Liu, Lei Jia, Qiuting Dong, Kefei Dou   +17 more
doaj   +1 more source

Clinical, socioeconomic, and behavioural factors at age 50 years and risk of cardiometabolic multimorbidity and mortality: A cohort study [PDF]

, 2018
BACKGROUND: Multimorbidity is increasingly common and is associated with adverse health outcomes, highlighting the need to broaden the single-disease framework that dominates medical research.
Dugravot, A, Fayosse, A, Kivimäki, M, Sabia, S, Shipley, M, Singh-Manoux, A, Tabak, A   +6 more
core   +1 more source

Multidisciplinary lifestyle intervention in children and adolescents - results of the project GRIT (Growth, Resilience, Insights, Thrive) pilot study [PDF]

, 2020
Background: During childhood and adolescence leading behavioural risk factors for the development of cardiometabolic diseases include poor diet quality and sedentary lifestyle.
, Cohen, Felicity, Isenring, Elizabeth, Marshall, Skye, Mayr, Hannah L, Soenen, Stijn   +5 more
core   +1 more source

Rationale and design of a randomized controlled trial: The effect of intensive lipid-lowering therapy with PCSK9 inhibitor on endothelial-coverage of stent strut after percutaneous coronary intervention (PCI) for patients with acute coronary syndrome (ACS): Optical coherence tomography (OCT) study (PIECES-OCT study)

Heliyon, 2023
Background: For the patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI), dual antiplatelet therapy (DAPT) for at least 1 year is recommended in the guidelines to minimize the risk of stent thrombosis ...
Zheng Yin, Zhi-Fan Li, Wen-Jia Zhang, Shuang Zhang, Yong-Gang Sui, Yan-Lu Xu, Hai-Tao Zhang, Xiao-Ning Liu, Hong Qiu, Jing-Lin Zhao, Jian-Jun Li, Ke-Fei Dou, Jie Qian, Yong-Jian Wu, Na-Qiong Wu   +14 more
doaj   +1 more source

Associations between cardiorespiratory fitness, physical activity and clustered cardiometabolic risk in children and adolescents: the HAPPY study [PDF]

, 2012
Clustering of cardiometabolic risk factors can occur during childhood and predisposes individuals to cardiometabolic disease. This study calculated clustered cardiometabolic risk in 100 children and adolescents aged 10-14 years (59 girls) and explored ...
A Moran, AS Gami, AS Kelly, AV Rowlands, AV Rowlands, B Gutin, B Gutin, C Boreham, C Bouchard, C Mattocks, C Riddoch, Catherine J. Kerr, D Martinez-Gomez, Daniel P. Bailey, F Abbasi, G Baquet, G Stratton, GQ Shaibi, GS Berenson, HC McGill Jr, HD McCarthy, I Graham, IM Lee, JA Hawley, JR Ruiz, JR Ruiz, JV Freeman, JW Twisk, JW Twisk, K Patrick, L Aires, LM Boddy, Louise A. Savory, Lynne M. Boddy, MK Holten, MS Mitchell, ND Ridgers, P Parikh, P Zimmet, S Brage, SA Anderssen, Sarah J. Denton, SH Golden, SJ Fairclough, SM Camhi, SN Blair, T Shemesh, TJ Cole, TS Hannon, U Ekelund, U Ekelund, W Chen   +51 more
core   +2 more sources

Amine oxidase copper-containing 3 (AOC3) inhibition: a potential novel target for the management of diabetic retinopathy

International Journal of Retina and Vitreous, 2021
Background Diabetic retinopathy (DR), a microvascular complication of diabetes, is the leading cause of visual impairment in people aged 20–65 years and can go undetected until vision is irreversibly lost.
David S. Boyer, Joerg F. Rippmann, Michael S. Ehrlich, Remko A. Bakker, Victor Chong, Quan Dong Nguyen   +5 more
doaj   +1 more source

Evaluation of waist-to-height ratio to predict 5 year cardiometabolic risk in sub-Saharan African adults [PDF]

, 2014
Simple, low-cost central obesity measures may help identify individuals with increased cardiometabolic disease risk, although it is unclear which measures perform best in African adults.
Fourie, C.M.T., Greeff, M., Huisman, H.W., Kruger, H. Salome, Kruger, I.M., Kruger, R., Rennie, Kirsten, Scheepers, J.D.W., Schutte, A.E., Schutte, R., Uys, A.S., Van Rooyen, J.M., Ware, L.J.   +12 more
core   +1 more source