Results 111 to 120 of about 171,003 (305)

Long‐term impact of Elexacaftor/Tezacaftor/ivacaftor on pulmonary, nutritional and metabolic outcomes in homozygous F508del cystic fibrosis patients: A real‐world cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aim Elexacaftor/tezacaftor/ivacaftor (ETI) has markedly improved cystic fibrosis (CF) outcomes. However, its long‐term impact on nutrition, metabolism and liver health remains underexplored. We assessed 30‐month changes in pulmonary, nutritional, metabolic and inflammatory markers in people with CF (PwCF) homozygous for F508del.
Nicola Perrotta, Luigi Angelo Fiorito, Roberta Vescovo, Anna Virgilio, Giulia Amato, Giuseppe Cimino   +5 more
wiley   +1 more source

Dairy consumption and cardiometabolic diseases: systematic review and updated meta-analyses of prospective cohort studies [PDF]

, 2018
Purpose of Review Dairy products contain both beneficial and harmful nutrients in relation to cardiometabolic diseases. Here, we provide the latest scientific evidence regarding the relationship between dairy products and cardiometabolic diseases by ...
A Hruby, A Lamri, A Tremblay, A Tremblay, AG Pittas, B Haring, B Lamarche, BJ Fuhrman, D Aune, D Gao, D Hu, D Kromhout, D Mozaffarian, D Mozaffarian, Daniel Lisko, DD Alexander, DI Givens, Doreen Gille, E Yu, EM Brouwer-Brolsma, F Rosqvist, FP Hartwig, G Buckland, GC Chen, Global Burden of Disease Risk Factors Collaborators, Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration, GW Dalmeijer, HEK Virtanen, HK Bergholdt, HK Bergholdt, HK Choi, I Sluijs, J Bodner-Montville, J Goede de, J Praagman, J Praagman, JA Nettleton, Jing Guo, JJ Dinicolantonio, JM Geleijnse, JP Drouin-Chartier, JP Drouin-Chartier, JP Higgins, JR Benatar, K Ge, KM Turner, L Brink, L Gijsbers, L Pimpin, L Schwingshackl, LA Mierlo van, LET Vissers, LM O'Connor, LQ Qin, M Chen, M Ding, M Kratz, M Talaei, M Talaei, M Talaei, M Talaei, MA Aerde van, MC Oliveira Otto de, ME Labonte, Mendelian Randomization of Dairy Consumption Working Group, MU Jakobsen, N Moslehi, NM Grantham, P Elwood, PC Elwood, Q Liu, Q Yang, R Villegas, S Greenland, S Parvez, Shuang Tian, SR Bauer, SS Lim, SS Soedamah-Muthu, SS Soedamah-Muthu, U Ericson, V Dilis, X Tong   +82 more
core   +3 more sources

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source

Screen time is associated with adiposity and insulin resistance in children [PDF]

, 2017
Higher screen time is associated with type 2 diabetes (T2D) risk in adults, but the association with T2D risk markers in children is unclear. We examined associations between self-reported screen time and T2D risk markers in children.
Cook, Derek G., Donin, Angela S., Nightingale, Claire M., Owen, Christopher G., Rudnicka, Alicja R., Sattar, Naveed, Whincup, Peter H.   +6 more
core   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Effects of breaking up prolonged sitting following low and high glycaemic index breakfast consumption on glucose and insulin concentrations [PDF]

, 2017
Purpose: Breaking up prolonged sitting can attenuate the postprandial rise in glucose and insulin. Whether such effects are dependent of the glycaemic index (GI) of the consumed carbohydrate is unknown.
Bailey, Daniel, Fruer, Julia, Fruer, Julia, Maylor, Benjamin, Orton, Charlie J.   +4 more
core   +3 more sources

Paternal use of metformin and risk of major congenital malformations: A meta‐analysis of 4 studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Metformin is the first‐line drug for the treatment of Type 2 diabetes. In 2022, a Danish registry‐based study reported a 40% increased risk of major congenital malformations following paternal exposure during spermatogenesis. This raised widespread concern about the use of metformin in males of reproductive age.
Per Damkier, Marleen M. H. J. van Gelder, Krista F. Huybrechts, Lin‐Chieh Meng, Sonia Hernandez‐Diaz, Jan Nielsen, Bente M. Nørgård, Hedvig Nordeng   +7 more
wiley   +1 more source

Sugar-containing beverage intake at the age of 1 year and cardiometabolic health at the age of 6 years: The Generation R Study [PDF]

, 2015
Background: Consumption of sugar-containing beverages (SCBs) in adults has been associated with an increased risk of metabolic syndrome. Although the effect of SCB on body weight in children is well established, little is known about the cardiometabolic ...
Felix, J.F. (Janine), Franco, O.H. (Oscar), Jaddoe, V.W.V. (Vincent), Kiefte-de Jong, J.C. (Jessica), Leermakers, E.T.M. (Lisan), Raat, H. (Hein)   +5 more
core   +1 more source

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

Associations of epigenetic age acceleration at birth and age 12 years with adolescent cardiometabolic risk: the HOME study

Clinical Epigenetics
Background Cardiometabolic risk factors among youth are rising. Epigenetic age acceleration, a biomarker for aging and disease-risk, has been associated with adiposity in children, but its association with other cardiometabolic risk markers remains ...
Jennifer L. Arzu, Karl T. Kelsey, George D. Papandonatos, Kim M. Cecil, Aimin Chen, Scott M. Langevin, Bruce P. Lanphear, Kimberly Yolton, Jessie P. Buckley, Joseph M. Braun   +9 more
doaj   +1 more source