Results 81 to 90 of about 144,668 (287)

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Allogeneic mesenchymal stromal cells overexpressing mutant human Hypoxia-inducible factor 1-α (HIF1-α) in an ovine model of acute myocardial infarction [PDF]

, 2016
Background-Bone marrow mesenchymal stromal cells (BMMSCs) are cardioprotective in acute myocardial infarction (AMI) because of release of paracrine angiogenic and prosurvival factors.
Crottogini, Alberto José, De Lorenzi, Andrea, Giménez, Carlos Sebastián, Hnatiuk, Anna, Jen, Cheng Hao, Laguens, Rubén, Lee, Won Hee, Locatelli, Paola, Olea, Fernanda Daniela, Ong, Sang-Ging, Riegler, Johannes, Wu, Joseph C.   +11 more
core   +1 more source

Atrial cardiomyocyte calcium signalling

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
Whereas Ca(2+) signalling in ventricular cardiomyocytes is well described, much less is known regarding the Ca(2+) signals within atrial cells. This is surprising given that atrial cardiomyocytes make an important contribution to the refilling of ventricles with blood, which enhances the subsequent ejection of blood from the heart.
Bootman, Martin D., Smyrnias, Ioannis, Thul, Ruediger, Coombes, Stephen, Roderick, H. Llewelyn   +4 more
openaire   +3 more sources

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Increasing Tetrahydrobiopterin in Cardiomyocytes Adversely Affects Cardiac Redox State and Mitochondrial Function Independently of Changes in NO Production [PDF]

, 2016
Tetrahydrobiopterin (BH4) represents a potential strategy for the treatment of cardiac remodeling, fibrosis and/or diastolic dysfunction. The effects of oral treatment with BH4 (Sapropterin™ or Kuvan™) are however dose-limiting with high dose negating ...
Bennett, Brian, Ionova, Irina A., Pieper, Galen M., Sethumadhavan, Savitha, Vasquez-Vivar, Jeannette, Whitsett, Jennifer   +5 more
core   +1 more source

Fractalkine Depresses Cardiomyocyte Contractility

PLoS ONE, 2013
Our laboratory reported that male mice with cardiomyocyte-selective knockout of the prostaglandin E2 EP4 receptor sub-type (EP4 KO) exhibit reduced cardiac function. Gene array on left ventricles (LV) showed increased fractalkine, a chemokine implicated in heart failure. We therefore hypothesized that fractalkine is regulated by PGE2 and contributes to
David Taube, Jiang Xu, Xiao-Ping Yang, Albertas Undrovinas, Edward Peterson, Pamela Harding   +5 more
openaire   +4 more sources

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

MicroRNAs in cardiomyocyte development [PDF]

WIREs Systems Biology and Medicine, 2010
AbstractMicroRNAs (miRNAs) negatively regulate gene expression at the post‐ transcriptional level, primarily by base‐pairing with the 3′‐untranslated region (3′‐UTR) of their target mRNAs. Many miRNAs are expressed in a tissue/organ‐specific manner and are associated with an increasing number of cell proliferation, differentiation, and tissue ...
Andrea P, Malizia, Da-Zhi, Wang
openaire   +2 more sources

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. [PDF]

, 2018
FRET-based biosensor experiments in adult cardiomyocytes are a powerful way of dissecting the spatiotemporal dynamics of the complicated signaling networks that regulate cardiac health and disease. However, although much information has been gleaned from
Chen-Izu, Ye, Jaradeh, Mark, Jian, Zhong, Reddy, Gopireddy Raghavender, Shi, Qian, Wang, Ying, West, Toni M, Xiang, Yang K   +7 more
core