Results 71 to 80 of about 146,196 (353)

3D Cardiac Cell Culture: A Critical Review of Current Technologies and Applications

Frontiers in Cardiovascular Medicine, 2019
Three-dimensional (3D) cell culture is often mentioned in the context of regenerative medicine, for example, for the replacement of ischemic myocardium with tissue-engineered muscle constructs.
Christian Zuppinger
doaj   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Determination of L-Type Calcium Current in the Primary Hypertrophied Left Ventricular Cardiomyocytes of Hypertrophy Heart Rats/HHR [PDF]

, 2009
Background: The molecular mechanisms responsible for electromechanical derangements found in primary left ventricular (LV) hypertrophy have not been clearly elucidated.
Danes, V. R. (Vennetia), Danes, Vennetia R.   +1 more
core   +1 more source

Cardiomyocyte‐Specific Snrk Prevents Inflammation in the Heart

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The SNRK (sucrose‐nonfermenting–related kinase) enzyme is critical for cardiac function. However, the underlying cause for heart failure observed in Snrk cardiac conditional knockout mouse is unknown.
Karthikeyan Thirugnanam, Stephanie M. Cossette, Qiulun Lu, Shreya R. Chowdhury, Leanne M. Harmann, Ankan Gupta, Andrew D. Spearman, Dmitry L. Sonin, Michelle Bordas, Suresh N. Kumar, Amy Y. Pan, Pippa M. Simpson, Jennifer L. Strande, Erin Bishop, Ming‐Hui Zou, Ramani Ramchandran   +15 more
doaj   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Periplocymarin Plays an Efficacious Cardiotonic Role via Promoting Calcium Influx

Frontiers in Pharmacology, 2020
Periplocymarin, which belongs to cardiac glycosides, is an effective component extracted from Periplocae Cortex. However, its cardiovascular effects remain unidentified. In the present study, injection of periplocymarin (5 mg/kg) through external jugular
Weijing Yun, Lei Qian, Yanyan Cheng, Weiwei Tao, Ruqiang Yuan, Hu Xu   +5 more
doaj   +1 more source

MicroRNAs in cardiomyocyte development [PDF]

WIREs Systems Biology and Medicine, 2010
AbstractMicroRNAs (miRNAs) negatively regulate gene expression at the post‐ transcriptional level, primarily by base‐pairing with the 3′‐untranslated region (3′‐UTR) of their target mRNAs. Many miRNAs are expressed in a tissue/organ‐specific manner and are associated with an increasing number of cell proliferation, differentiation, and tissue ...
Andrea P, Malizia, Da-Zhi, Wang
openaire   +2 more sources

Cardiomyocyte-specific Cre-mediated recombination.

, 2015
(A) Representative flow cytometry plots depicting the gating strategy for sorting of cardiomyocyte nuclei. Positive 7-AAD (left panel) and PCM-1 (middle panel) staining identified cardiomyocyte nuclei.
Thomas G. Nührenberg (758785), Sebastian Preißl (758788), Nils Hammann (758786), Lutz Hein (69036), Anika Witten (634390), Franz-Josef Neumann (758789), Tilman Schnick (758787), Ralf Gilsbach (69034), Monika Stoll (77524)   +8 more
core   +1 more source

In vitro epigenetic reprogramming of human cardiac mesenchymal stromal cells into functionally competent cardiovascular precursors [PDF]

, 2012
Adult human cardiac mesenchymal-like stromal cells (CStC) represent a relatively accessible cell type useful for therapy. In this light, their conversion into cardiovascular precursors represents a potential successful strategy for cardiac repair.
Andrea Barbuti (106295), A. Barbuti, Rossini, Alessandra, Simona Nanni, Nanni, Simona, Barbuti, Andrea, C. Gaetano, Meraviglia Viviana, Carlo Gaetano (110837), Meraviglia, Viviana, Capogrossi, Maurizio C., Pompilio Giulio, Gualtiero I Colombo, Angela Scavone, Simona Nanni (110816), Maurizio C Capogrossi, S. Nanni, Scavone Angela, Matteo Vecellio, Viviana Meraviglia (110811), DiFrancesco Dario, A. Scavone, Antonella Farsetti, Alessandra Rossini (110841), Viviana Meraviglia, Colombo Gualtiero I., Dario DiFrancesco, Pompilio, Giulio, Gaetano, Carlo, Vecellio, Matteo, Nanni Simona, Maurizio C. Capogrossi (103525), D. DiFrancesco, Giulio Pompilio (103510), Gaetano Carlo, Carlo Gaetano, Colombo, Gualtiero I., Vecellio Matteo, Farsetti Antonella, A. Farsetti, Angela Scavone (110822), M. Vecellio, Farsetti, Antonella, Barbuti Andrea, Capogrossi Maurizio C., Rossini Alessandra, G.I. Colombo, Giulio Pompilio, Antonella Farsetti (110827), V. Meraviglia, Alessandra Rossini, Andrea Barbuti, DiFrancesco, Dario, Dario DiFrancesco (106304), M. C. Capogrossi, Gualtiero I. Colombo (103516), Scavone, Angela, Matteo Vecellio (110807), A. Rossini, G. Pompilio   +59 more
core   +2 more sources

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source