Results 51 to 60 of about 146,196 (353)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Hopx and the Cardiomyocyte Parentage [PDF]

Molecular Therapy, 2015
The dissection of steps that pattern primitive mesoderm toward the cardiovascular lineages is important to our current understanding of cardiovascular development and can instruct regenerative approaches to heart repair.1 Primitive precursors that can adopt a cardiovascular fate, but also a subset of other mesoderm, are marked by the transcription ...
Schneider, MD, Baker, AH, Riley, P
openaire   +3 more sources

Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation

JACC: Basic to Translational Science
Summary: Gene expression involves transcription, translation, and mRNA and protein degradation. Advanced RNA sequencing measures mRNA levels for cell state assessment, but mRNA level does not fully reflect protein level.
Shijie Liu, PhD, Vaibhav Deshmukh, PhD, Fangfei Wang, MD, Jie Liang, MS, Jenna Cusick, BS, Xiao Li, PhD, James F. Martin, MD, PhD   +6 more
doaj   +1 more source

Does Disruption of Optic Atrophy-1 (OPA1) Contribute to Cell Death in HL-1 Cardiomyocytes Subjected to Lethal Ischemia-Reperfusion Injury?

Cells, 2022
Disruption of mitochondrial structure/function is well-recognized to be a determinant of cell death in cardiomyocytes subjected to lethal episodes of ischemia-reperfusion (IR). However, the precise mitochondrial event(s) that precipitate lethal IR injury
Andrew R. Kulek, Vishnu V. R. Undyala, Anthony R. Anzell, Sarita Raghunayakula, Lee Ann MacMillan-Crow, Thomas H. Sanderson, Karin Przyklenk   +6 more
doaj   +1 more source

Guanosine‐Quadruplex Hydrogels as Dynamic, Mechanically Tunable and Ion Conductive 3D Scaffolds for Cell Culture Applications

Advanced Functional Materials, EarlyView.
Versatile guanosine‐quadruplex (GQ) hydrogels are developed as dynamic biomatrices for cell culture. These scaffolds are fabricated under mild aqueous conditions, present improved stability, tunable mechanical properties within physiological ranges; fibrillar, porous microstructure, ion conductivity, and cytocompatibility.
Neha Thakur, Minye Jin, Pavel Milkin, Deepa Negi, Carla Cofiño Fabres, Hubert Gojzewski, Leonid Ionov, Alla Synytska, Andries van der Meer, Robert Passier, Julieta I. Paez   +10 more
wiley   +1 more source

New Tricks with Old Dogs: Computational Identification and Experimental Validation of New miRNA–mRNA Regulation in hiPSC-CMs

Biomedicines, 2022
Cardiovascular disease is still the leading cause of morbidity and mortality worldwide. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have become a valuable widespread in vitro model to study cardiac disease.
Maja Bencun, Thiago Britto-Borges, Jessica Eschenbach, Christoph Dieterich   +3 more
doaj   +1 more source

A Generative AI Framework to Predict Cardiomyocyte Contraction Function From Single Static Images

Advanced Intelligent Discovery, EarlyView.
A single static hiPSC‐cardiomyocyte image is fed into a U‐Net‐GAN framework, which directly predicts a pixel‐resolved contraction heatmap without time‐lapse imaging. StyleGAN2‐generated synthetic cell–heatmap pairs augment training, improving prediction fidelity (SSIM = 0.84).
Andrew C. Kowalczewski, Chenyan Wang, Xinrui Wang, Huaxiao Yang, Zhao Qin, Zhen Ma   +5 more
openalex   +2 more sources

Configuration‐Encoded Cell Alignment by Light‐Gated Silicon Photovoltaic Microcell Arrays

Advanced Functional Materials, EarlyView.
Light‐gated silicon photovoltaic microcells convert pulsed illumination into localized electrical cues. Arranging otherwise similar microcells into four‐lobed, six‐lobed, or circular patterns directs fibroblasts into corresponding local arrangements without wired stimulation.
Yifan Tao, Ilayda Namli, Joseph Christakiran Moses, Youdi Liu, Suihong Liu, Syed Hasan Askari Rizvi, Yasar Ozer Yilmaz, Ibrahim T. Ozbolat   +7 more
wiley   +1 more source

Role of PDE4 Family in Cardiomyocyte Physiology and Heart Failure

Cells
Phosphodiesterase 4 (PDE4) is a key regulator of cyclic adenosine monophosphate (cAMP) signalling in cardiomyocytes, controlling contractility, calcium handling, and hypertrophic responses. PDE4 provides spatial and temporal precision to cAMP signalling,
Ivan Sherstnev, Aleksandra Judina, Giovanni Battista Luciani, Alessandra Ghigo, Emilio Hirsch, Julia Gorelik   +5 more
doaj   +1 more source

Cardiomyocyte proliferation, a target for cardiac regeneration [PDF]

, 2019
International audienceCardiac diseases, characterized by cardiomyocyte loss, lead to dramatic impairment of cardiac function and ultimately to congestive heart failure.
Payan, Sandy, Rochais, Francesca, Hubert, Fabien   +2 more
core   +1 more source