Results 31 to 40 of about 85,199 (269)
Frontiers in Cardiovascular Medicine, 2022 Cardiovascular diseases remain the leading cause of death worldwide, particularly ischemic heart disease (IHD). It is also classified as incurable given the irreversible damage it causes to cardiomyocytes.
Kele Qin +9 more
doaj +1 more source
Reprogramming Fibroblasts into Cardiomyocytes [PDF]
New England Journal of Medicine, 2011 The transdifferentiation of one differentiated cell type into another is the focus of much research activity. A recent study shows that mouse fibroblasts can be transdifferentiated, albeit with low efficiency, into cardiomyocytes.
Charles E, Murry, William T, Pu
openaire +2 more sources
Endothelial-Myocardial Angiocrine Signaling in Heart Development
Frontiers in Cell and Developmental Biology, 2021 Vascular endothelial cells are a multifunctional cell type with organotypic specificity in their function and structure. In this review, we discuss various subpopulations of endothelial cells in the mammalian heart, which spatiotemporally regulate ...
Hyeonyu Kim +5 more
doaj +1 more source
Compartmentation of cAMP in Cardiomyocytes [PDF]
, 2010 The second messenger cAMP is responsible for β-adrenergic receptor (-AR) stimulation of cardiac function by catecholamines, but is also elevated in response to several other receptors which exert distinct functional effects on the heart. Evidences that spatial segregation of cAMP signalling may explain these observations are reviewed in this chapter ...
Vandecasteele, Grégoire +1 more
openaire +2 more sources
TEAD-independent mechanisms of YAP function in cardiomyocyte cell cycle reentry
Life Science AllianceThis study demonstrates that YAP6SA promotes cardiomyocyte cell cycling through TEAD-independent pathways, suggesting a novel therapeutic approach for heart repair.
Bing Xie +10 more
doaj +1 more source
MicroRNAs in cardiomyocyte development [PDF]
WIREs Systems Biology and Medicine, 2010 AbstractMicroRNAs (miRNAs) negatively regulate gene expression at the post‐ transcriptional level, primarily by base‐pairing with the 3′‐untranslated region (3′‐UTR) of their target mRNAs. Many miRNAs are expressed in a tissue/organ‐specific manner and are associated with an increasing number of cell proliferation, differentiation, and tissue ...
Andrea P, Malizia, Da-Zhi, Wang
openaire +2 more sources
Mathematics, 2020 Electrical and mechanical stimulations play a key role in cell biological processes, being essential in processes such as cardiac cell maturation, proliferation, migration, alignment, attachment, and organization of the contractile machinery.
Pau Urdeitx, Mohamed H. Doweidar
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Cells, 2022 Disruption of mitochondrial structure/function is well-recognized to be a determinant of cell death in cardiomyocytes subjected to lethal episodes of ischemia-reperfusion (IR). However, the precise mitochondrial event(s) that precipitate lethal IR injury
Andrew R. Kulek +6 more
doaj +1 more source