Results 31 to 40 of about 103,439 (265)

Cardiomyocyte-specific deletion of Tead1 leads to early neonatal death by day 9 after birth.

, 2019
(A) Generation of Tead1 cardiomyocyte-specific knockout mice (Tead1-cKO) using knockout-first strategy: promoter-driven selection cassette. (B) Representative photograph of a Tead1-cKO breeding litter, demonstrating Tead1-cKO were born in Mendelian ...
Feng Li (30515), Rajaganapathi Jagannathan (104772), Byung S. Kim (3955703), Nikhil Balasubramanyam (6407207), Vijay K. Yechoor (389036), Mousumi Moulik (6407210), Ping Yang (56755), Jeongkyung Lee (389032), Ruya Liu (6407204)   +8 more
core   +1 more source

A Computational Model for Cardiomyocytes Mechano-Electric Stimulation to Enhance Cardiac Tissue Regeneration

Mathematics, 2020
Electrical and mechanical stimulations play a key role in cell biological processes, being essential in processes such as cardiac cell maturation, proliferation, migration, alignment, attachment, and organization of the contractile machinery.
Pau Urdeitx, Mohamed H. Doweidar
doaj   +1 more source

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo [PDF]

, 2022
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration.
Rackham, OJL, Cook, SA, Hardyman, Michelle A., Sheppard, MN, Sembrat, JC, Felkin, Leanne E, Cull, Joshua J, Meijles, Daniel N., Chothani, Sonia P, Clerk, A, McTiernan, CF, Cooper, Susanna TE, Felkin, Leanne E., Glennon, Peter E., Cook, Stuart A, Clerk, Angela, Alharbi, Hajed O, Alharbi, Hajed O., Sembrat, John C., Vanezis, K, Glennon, PE, Felkin, LE, Sugden, PH, Chothani, Sonia P., Cooper, Susanna T. E., Cook, Stuart A., Sugden, Peter H., McTiernan, Charles F, Fuller, Stephen J., Markou, T, Rojas, M, Cull, JJ, Leonard, SJ, McTiernan, Charles F., Rackham, Owen JL, Barton, Paul J., Cooper, STE, Sheppard, Mary N., Cull, Joshua J., Fuller, SJ, Hardyman, Michelle A, Barton, Paul J, Sheppard, Mary N, Fuller, Stephen J, Markou, Thomais, Rojas, Mauricio, Chothani, SP, Meijles, DN, Sembrat, John C, Barton, PJ, Shaw, SW, Sugden, Peter H, Meijles, Daniel N, Shaw, Spencer W, Leonard, Samuel J., Rackham, Owen J. L., Hardyman, MA, Glennon, Peter E, Alharbi, HO, Shaw, Spencer W., Leonard, Samuel J, Vanezis, Konstantinos   +61 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Cardiac Troponin I-interacting Kinase impacts cardiomyocyte S-phase activity but not cardiomyocyte proliferation

, 2023
Background: Identifying genetic variants that affect the level of cell cycle reentry and establishing the degree of cell cycle progression in those variants could help guide development of therapeutic interventions aimed at effecting cardiac regeneration.
Lee, Han Kyu, Reuter, Sean P., Sridhar, Arthi, Simpson, Ed, Field, Loren J., Soonpaa, Mark H., Li, Xiaochun, Field, Dorothy, Ware, Stephanie M., Green, Nick, Wollert, Kai C., Rubart-von der Lohe, Michael, Ofner, Susan, Marchuk, Douglas A.   +13 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

In Vivo Methods to Monitor Cardiomyocyte Proliferation

, 2022
Adult mammalian cardiomyocytes demonstrate scarce cycling and even lower proliferation rates in response to injury. Signals that enhance cardiomyocyte proliferation after injury will be groundbreaking, address unmet clinical needs, and represent new ...
Matthew J. Wolf, Leigh A. Bradley, Alexander Young   +2 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Does Disruption of Optic Atrophy-1 (OPA1) Contribute to Cell Death in HL-1 Cardiomyocytes Subjected to Lethal Ischemia-Reperfusion Injury?

Cells, 2022
Disruption of mitochondrial structure/function is well-recognized to be a determinant of cell death in cardiomyocytes subjected to lethal episodes of ischemia-reperfusion (IR). However, the precise mitochondrial event(s) that precipitate lethal IR injury
Andrew R. Kulek, Vishnu V. R. Undyala, Anthony R. Anzell, Sarita Raghunayakula, Lee Ann MacMillan-Crow, Thomas H. Sanderson, Karin Przyklenk   +6 more
doaj   +1 more source

Role of PDE4 Family in Cardiomyocyte Physiology and Heart Failure

Cells
Phosphodiesterase 4 (PDE4) is a key regulator of cyclic adenosine monophosphate (cAMP) signalling in cardiomyocytes, controlling contractility, calcium handling, and hypertrophic responses. PDE4 provides spatial and temporal precision to cAMP signalling,
Ivan Sherstnev, Aleksandra Judina, Giovanni Battista Luciani, Alessandra Ghigo, Emilio Hirsch, Julia Gorelik   +5 more
doaj   +1 more source