Results 31 to 40 of about 144,668 (287)

Ectopic expression of SARS-CoV-2 S and ORF-9B proteins alters metabolic profiles and impairs contractile function in cardiomyocytes

Frontiers in Cell and Developmental Biology, 2023
Coronavirus disease 2019 (COVID-19) is associated with adverse impacts in the cardiovascular system, but the mechanisms driving this response remain unclear.
Peng Zhang, Yu Liu, Chunfeng Li, Lindsay D. Stine, Pei-Hui Wang, Matthew W. Turnbull, Haodi Wu, Qing Liu, Qing Liu   +8 more
doaj   +1 more source

Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs. [PDF]

, 2020
Many crucial cardiovascular adaptations occur in the body during pregnancy to ensure successful gestation. Maladaptation of the cardiovascular system during pregnancy can lead to complications that promote cardiac dysfunction and may lead to heart ...
Aryan, Laila, Eghbali, Mansoureh, Medzikovic, Lejla, Umar, Soban   +3 more
core  

Ubiquitin Carboxyl-Terminal Hydrolase L1 of Cardiomyocytes Promotes Macroautophagy and Proteostasis and Protects Against Post-myocardial Infarction Cardiac Remodeling and Heart Failure

Frontiers in Cardiovascular Medicine, 2022
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinase known to play essential roles in the nervous tissue. Myocardial upregulation of UCHL1 was observed in human dilated cardiomyopathy and several animal models of heart disease, but the ...
Penglong Wu, Penglong Wu, Yifan Li, Mingqi Cai, Bo Ye, Bingchuan Geng, Faqian Li, Hua Zhu, Jinbao Liu, Xuejun Wang   +9 more
doaj   +1 more source

Myocardial Dysfunction in an Animal Model of Cancer Cachexia [PDF]

, 2011
Aims Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease.
Crawford, Danielle, Hutchinson, Kirk R., Lucchesi, Pamela A., McCarthy, Donna O., Velten, Markus, Wold, Loren E., Xu, Hui, Youtz, Dane J.   +7 more
core   +2 more sources

Differentiation of cardiomyocyte.

Folia Pharmacologica Japonica, 2000
In the recent decade, remarkable progress has been made in the field of cardiac development through the use of molecular, biological and genetic techniques. Several genes that regulate this process have been cloned, and their functions have been analyzed in vivo and in vitro.
T, Oka, I, Komuro
openaire   +3 more sources

SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling

eLife
The Hippo pathway controls organ development, homeostasis, and regeneration primarily by modulating YAP/TEAD-mediated gene expression. Although emerging studies report Hippo-YAP dysfunction after viral infection, it is largely unknown in the context of ...
Fansen Meng, Jong Hwan Kim, Chang-Ru Tsai, Jeffrey D Steimle, Jun Wang, Yufeng Shi, Rich G Li, Bing Xie, Vaibhav Deshmukh, Shijie Liu, Xiao Li, James F Martin   +11 more
doaj   +1 more source

Mitochondrial calcium signaling and redox homeostasis in cardiac health and disease

Frontiers in Molecular Medicine, 2023
The energy demand of cardiomyocytes changes continuously in response to variations in cardiac workload. Cardiac excitation-contraction coupling is fueled primarily by adenosine triphosphate (ATP) production by oxidative phosphorylation in mitochondria ...
Tudor-Alexandru Popoiu, Tudor-Alexandru Popoiu, Christoph Maack, Edoardo Bertero, Edoardo Bertero   +4 more
doaj   +1 more source

Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. [PDF]

, 2019
Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully elucidated.
Amaral, Maria Luisa, Chee, Sora, Chi, Neil C, Destici, Eugin, Evans, Sylvia M, Fang, Rongxin, Farah, Elie N, Grinstein, Jonathan D, Hu, Rong, Huang, Hui, Izpisua Belmonte, Juan Carlos, Lee, Ah Young, Li, Ting, Ma, Kaiyue, Preissl, Sebastian, Qiu, Yunjiang, Ren, Bing, Wu, Jun, Ye, Zhen, Yu, Leqian, Zhang, Yanxiao, Zhu, Quan   +21 more
core   +2 more sources

Non-coding RNAs to regulate cardiomyocyte proliferation: A new trend in therapeutic cardiac regeneration

Frontiers in Cardiovascular Medicine, 2022
Cardiovascular diseases remain the leading cause of death worldwide, particularly ischemic heart disease (IHD). It is also classified as incurable given the irreversible damage it causes to cardiomyocytes.
Kele Qin, Xiaohui Xie, Weijie Tang, Danni Yang, Jun Peng, Jianjun Guo, Jinfu Yang, Chengming Fan, Chengming Fan, Chengming Fan   +9 more
doaj   +1 more source

Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes [PDF]

, 2003
Background - Further to promoting angiogenesis, cell therapy may be an approach for cardiac regeneration. Recent studies suggest that progenitor cells can transdifferentiate into other lineages. However, the transdifferentiation potential of endothelial
Aicher, A, Badorff, C, Brandes, RP, Busse, R, Dimmeler, S, Fleming, I, Popp, R, Rupp, S, Urbich, C, Zeiher, AM   +9 more
core   +1 more source