Results 31 to 40 of about 146,196 (353)

Chamber-Specific Protein Expression during Direct Cardiac Reprogramming

Cells, 2021
Forced expression of core cardiogenic transcription factors can directly reprogram fibroblasts to induced cardiomyocyte-like cells (iCMs) in vitro and in vivo. This cardiac reprogramming approach provides a proof of concept for induced heart regeneration
Zhentao Zhang, Jesse Villalpando, Wenhui Zhang, Young-Jae Nam   +3 more
doaj   +1 more source

Cardiomyocyte Regeneration [PDF]

Circulation, 2017
Consensus ...
Eschenhagen, T, Bolli, R, Braun, T, Field, LJ, Fleischmann, BK, Frisén, J, Giacca, M, Hare, JM, Houser, S, Lee, RT, Marbán, E, Martin, JF, Molkentin, JD, Murry, CE, Riley, PR, Ruiz-Lozano, P, Sadek, HA, Sussman, MA, Hill, JA   +18 more
openaire   +6 more sources

Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats [PDF]

, 2011
Impaired cardiac control of intracellular diastolic Ca²⁺ gives rise to arrhythmias. Whereas exercise training corrects abnormal cyclic Ca²⁺ handling in heart failure, the effect on diastolic Ca<sup>2 ...
Kemi, Ole J., Wisloff, Ulrik, Morten A. Hoydal, MacQuaide, Niall, Godfrey L. Smith, Hoydal, Morten A., Smith, Godfrey L., Ellingsen, Oyvind, Oyvind Ellingsen, Smith, Godfrey L, Niall MacQuaide, Ole J. Kemi, Ulrik Wisloff   +12 more
core   +1 more source

Ectopic expression of SARS-CoV-2 S and ORF-9B proteins alters metabolic profiles and impairs contractile function in cardiomyocytes

Frontiers in Cell and Developmental Biology, 2023
Coronavirus disease 2019 (COVID-19) is associated with adverse impacts in the cardiovascular system, but the mechanisms driving this response remain unclear.
Peng Zhang, Yu Liu, Chunfeng Li, Lindsay D. Stine, Pei-Hui Wang, Matthew W. Turnbull, Haodi Wu, Qing Liu, Qing Liu   +8 more
doaj   +1 more source

Preprint: Analysis of cardiomyocyte nuclei in human cardiomyopathy reveals orientation dependent defects in shape

, 2020
Cardiomyopathies are progressive diseases of heart muscle often caused by mutations in genes encoding sarcomeric, cytoskeletal and nucleoskeletal proteins though in many cases the cause of disease is not identified.
Ehler, E., Brayson, D., Shanahan, C.M., dos Remedios, C.G.   +3 more
core   +1 more source

Ubiquitin Carboxyl-Terminal Hydrolase L1 of Cardiomyocytes Promotes Macroautophagy and Proteostasis and Protects Against Post-myocardial Infarction Cardiac Remodeling and Heart Failure

Frontiers in Cardiovascular Medicine, 2022
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinase known to play essential roles in the nervous tissue. Myocardial upregulation of UCHL1 was observed in human dilated cardiomyopathy and several animal models of heart disease, but the ...
Penglong Wu, Penglong Wu, Yifan Li, Mingqi Cai, Bo Ye, Bingchuan Geng, Faqian Li, Hua Zhu, Jinbao Liu, Xuejun Wang   +9 more
doaj   +1 more source

Nucleus Mechanosensing in Cardiomyocytes

International Journal of Molecular Sciences, 2023
Cardiac muscle contraction is distinct from the contraction of other muscle types. The heart continuously undergoes contraction–relaxation cycles throughout an animal’s lifespan. It must respond to constantly varying physical and energetic burdens over the short term on a beat-to-beat basis and relies on different mechanisms over the long term.
Isabella Leite Coscarella, Maicon Landim-Vieira, Hosna Rastegarpouyani, Prescott Bryant Chase, Jerome Irianto, Jose Renato Pinto   +5 more
openaire   +2 more sources

SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling

eLife
The Hippo pathway controls organ development, homeostasis, and regeneration primarily by modulating YAP/TEAD-mediated gene expression. Although emerging studies report Hippo-YAP dysfunction after viral infection, it is largely unknown in the context of ...
Fansen Meng, Jong Hwan Kim, Chang-Ru Tsai, Jeffrey D Steimle, Jun Wang, Yufeng Shi, Rich G Li, Bing Xie, Vaibhav Deshmukh, Shijie Liu, Xiao Li, James F Martin   +11 more
doaj   +1 more source

Mitochondrial calcium signaling and redox homeostasis in cardiac health and disease

Frontiers in Molecular Medicine, 2023
The energy demand of cardiomyocytes changes continuously in response to variations in cardiac workload. Cardiac excitation-contraction coupling is fueled primarily by adenosine triphosphate (ATP) production by oxidative phosphorylation in mitochondria ...
Tudor-Alexandru Popoiu, Tudor-Alexandru Popoiu, Christoph Maack, Edoardo Bertero, Edoardo Bertero   +4 more
doaj   +1 more source

Non-coding RNAs to regulate cardiomyocyte proliferation: A new trend in therapeutic cardiac regeneration

Frontiers in Cardiovascular Medicine, 2022
Cardiovascular diseases remain the leading cause of death worldwide, particularly ischemic heart disease (IHD). It is also classified as incurable given the irreversible damage it causes to cardiomyocytes.
Kele Qin, Xiaohui Xie, Weijie Tang, Danni Yang, Jun Peng, Jianjun Guo, Jinfu Yang, Chengming Fan, Chengming Fan, Chengming Fan   +9 more
doaj   +1 more source