Results 21 to 30 of about 103,439 (265)

Ectopic expression of SARS-CoV-2 S and ORF-9B proteins alters metabolic profiles and impairs contractile function in cardiomyocytes

Frontiers in Cell and Developmental Biology, 2023
Coronavirus disease 2019 (COVID-19) is associated with adverse impacts in the cardiovascular system, but the mechanisms driving this response remain unclear.
Peng Zhang, Yu Liu, Chunfeng Li, Lindsay D. Stine, Pei-Hui Wang, Matthew W. Turnbull, Haodi Wu, Qing Liu, Qing Liu   +8 more
doaj   +1 more source

Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats [PDF]

, 2011
Impaired cardiac control of intracellular diastolic Ca²⁺ gives rise to arrhythmias. Whereas exercise training corrects abnormal cyclic Ca²⁺ handling in heart failure, the effect on diastolic Ca<sup>2 ...
Kemi, Ole J., Wisloff, Ulrik, Morten A. Hoydal, MacQuaide, Niall, Godfrey L. Smith, Hoydal, Morten A., Smith, Godfrey L., Ellingsen, Oyvind, Oyvind Ellingsen, Smith, Godfrey L, Niall MacQuaide, Ole J. Kemi, Ulrik Wisloff   +12 more
core   +1 more source

Ubiquitin Carboxyl-Terminal Hydrolase L1 of Cardiomyocytes Promotes Macroautophagy and Proteostasis and Protects Against Post-myocardial Infarction Cardiac Remodeling and Heart Failure

Frontiers in Cardiovascular Medicine, 2022
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinase known to play essential roles in the nervous tissue. Myocardial upregulation of UCHL1 was observed in human dilated cardiomyopathy and several animal models of heart disease, but the ...
Penglong Wu, Penglong Wu, Yifan Li, Mingqi Cai, Bo Ye, Bingchuan Geng, Faqian Li, Hua Zhu, Jinbao Liu, Xuejun Wang   +9 more
doaj   +1 more source

Preprint: Analysis of cardiomyocyte nuclei in human cardiomyopathy reveals orientation dependent defects in shape

, 2020
Cardiomyopathies are progressive diseases of heart muscle often caused by mutations in genes encoding sarcomeric, cytoskeletal and nucleoskeletal proteins though in many cases the cause of disease is not identified.
Ehler, E., Brayson, D., Shanahan, C.M., dos Remedios, C.G.   +3 more
core   +1 more source

SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling

eLife
The Hippo pathway controls organ development, homeostasis, and regeneration primarily by modulating YAP/TEAD-mediated gene expression. Although emerging studies report Hippo-YAP dysfunction after viral infection, it is largely unknown in the context of ...
Fansen Meng, Jong Hwan Kim, Chang-Ru Tsai, Jeffrey D Steimle, Jun Wang, Yufeng Shi, Rich G Li, Bing Xie, Vaibhav Deshmukh, Shijie Liu, Xiao Li, James F Martin   +11 more
doaj   +1 more source

Mitochondrial calcium signaling and redox homeostasis in cardiac health and disease

Frontiers in Molecular Medicine, 2023
The energy demand of cardiomyocytes changes continuously in response to variations in cardiac workload. Cardiac excitation-contraction coupling is fueled primarily by adenosine triphosphate (ATP) production by oxidative phosphorylation in mitochondria ...
Tudor-Alexandru Popoiu, Tudor-Alexandru Popoiu, Christoph Maack, Edoardo Bertero, Edoardo Bertero   +4 more
doaj   +1 more source

Non-coding RNAs to regulate cardiomyocyte proliferation: A new trend in therapeutic cardiac regeneration

Frontiers in Cardiovascular Medicine, 2022
Cardiovascular diseases remain the leading cause of death worldwide, particularly ischemic heart disease (IHD). It is also classified as incurable given the irreversible damage it causes to cardiomyocytes.
Kele Qin, Xiaohui Xie, Weijie Tang, Danni Yang, Jun Peng, Jianjun Guo, Jinfu Yang, Chengming Fan, Chengming Fan, Chengming Fan   +9 more
doaj   +1 more source

Endothelial-Myocardial Angiocrine Signaling in Heart Development

Frontiers in Cell and Developmental Biology, 2021
Vascular endothelial cells are a multifunctional cell type with organotypic specificity in their function and structure. In this review, we discuss various subpopulations of endothelial cells in the mammalian heart, which spatiotemporally regulate ...
Hyeonyu Kim, Hyeonyu Kim, Mingqiang Wang, Mingqiang Wang, David T. Paik, David T. Paik   +5 more
doaj   +1 more source

Data_Sheet_2_Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice.PDF [PDF]

, 2019
Cardiomyocyte proliferation accounts for the increase of cardiac muscle during fetal mammalian heart development. Shortly after birth, cardiomyocyte transits from hyperplasia to hypertrophic growth.
Brian N. Finck, Tani Leigh, Konstantinos Drosatos (5209304), Tongtong Cao, Daniela Liccardo (615764), Liccardo, Daniela, Zhang, Xiaoying, Tani Leigh (6498707), Cao, Tongtong, Drosatos, Konstantinos, Rong Lu, Ying Tian, Leigh, Tani, Lu, Rong, Xiongwen Chen, Chen, Xiongwen, Xiaoying Zhang, Konstantinos Drosatos, Daniela Liccardo, Brian N. Finck (106944), Finck, Brian N, Tian, Ying, Xiaoying Zhang (52883), Xiongwen Chen (316075), Rong Lu (53910), Tongtong Cao (6498701), Ryan LaCanna (6498704), Ryan LaCanna, Ying Tian (180972), LaCanna, Ryan   +29 more
core   +1 more source

TEAD-independent mechanisms of YAP function in cardiomyocyte cell cycle reentry

Life Science Alliance
This study demonstrates that YAP6SA promotes cardiomyocyte cell cycling through TEAD-independent pathways, suggesting a novel therapeutic approach for heart repair.
Bing Xie, Jeffrey Steimle, Vaibhav Deshmukh, Lin Liu, Chang-Ru Tsai, Todd R Heallen, Wyatt Paltzer, Yuka Morikawa, Fansen Meng, Jun Wang, James F Martin   +10 more
doaj   +1 more source