Results 21 to 30 of about 85,199 (269)
Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication
Frontiers in Physiology, 2014 Most studies of the heart focus on cardiomyocytes (CM) at the exclusion of other cell types such as myocardial endothelial cells (EC). Such mono-cellular approaches propagate the presumption that EC provide a mere passive lining or supportive role.
Thorsten M. Leucker, Steven P. Jones
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Immunity, Inflammation and Disease, 2021 Background The long noncoding RNA, cardiac autophagy inhibitory factor (CAIF), and microRNA (miR)‐16 are reported to be involved in lipopolysaccharide (LPS)‐induced inflammatory responses and cell apoptosis in many diseases.
Yan Wang, Yi Zhang
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Frontiers in Physiology, 2015 Mathematical modelling of excitation-contraction coupling (ECC) in ventricular cardiac myocytes is a multiscale problem, and it is therefore difficult to develop spatially detailed simulation tools. ECC involves gradients on the length scale of 100 nm in
Janine eVierheller +4 more
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Chamber-Specific Protein Expression during Direct Cardiac Reprogramming
Cells, 2021 Forced expression of core cardiogenic transcription factors can directly reprogram fibroblasts to induced cardiomyocyte-like cells (iCMs) in vitro and in vivo. This cardiac reprogramming approach provides a proof of concept for induced heart regeneration
Zhentao Zhang +3 more
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Frontiers in Cell and Developmental Biology, 2023 Coronavirus disease 2019 (COVID-19) is associated with adverse impacts in the cardiovascular system, but the mechanisms driving this response remain unclear.
Peng Zhang +8 more
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Frontiers in Cardiovascular Medicine, 2022 Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinase known to play essential roles in the nervous tissue. Myocardial upregulation of UCHL1 was observed in human dilated cardiomyopathy and several animal models of heart disease, but the ...
Penglong Wu +9 more
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Hopx and the Cardiomyocyte Parentage [PDF]
Molecular Therapy, 2015 The dissection of steps that pattern primitive mesoderm toward the cardiovascular lineages is important to our current understanding of cardiovascular development and can instruct regenerative approaches to heart repair.1 Primitive precursors that can adopt a cardiovascular fate, but also a subset of other mesoderm, are marked by the transcription ...
Schneider, MD, Baker, AH, Riley, P
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SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling
eLifeThe Hippo pathway controls organ development, homeostasis, and regeneration primarily by modulating YAP/TEAD-mediated gene expression. Although emerging studies report Hippo-YAP dysfunction after viral infection, it is largely unknown in the context of ...
Fansen Meng +11 more
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Mitochondrial calcium signaling and redox homeostasis in cardiac health and disease
Frontiers in Molecular Medicine, 2023 The energy demand of cardiomyocytes changes continuously in response to variations in cardiac workload. Cardiac excitation-contraction coupling is fueled primarily by adenosine triphosphate (ATP) production by oxidative phosphorylation in mitochondria ...
Tudor-Alexandru Popoiu +4 more
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Transplantation of cryopreserved cardiomyocytes [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2001 The present study examined the survival and rate of contraction of (1) cardiomyocytes cultured from cryopreserved fetal rat myocardium and (2) cryopreserved cultured cardiomyocytes. In addition, the effects of transplantation of cryopreserved fetal cardiomyocytes were evaluated.Segments of fetal rat myocardial tissue (0.2, 2.0, and 6.0 mm(3) mince size)
Yokomuro, Hiroki +5 more
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