Results 41 to 50 of about 146,196 (353)

TEAD-independent mechanisms of YAP function in cardiomyocyte cell cycle reentry

Life Science Alliance
This study demonstrates that YAP6SA promotes cardiomyocyte cell cycling through TEAD-independent pathways, suggesting a novel therapeutic approach for heart repair.
Bing Xie, Jeffrey Steimle, Vaibhav Deshmukh, Lin Liu, Chang-Ru Tsai, Todd R Heallen, Wyatt Paltzer, Yuka Morikawa, Fansen Meng, Jun Wang, James F Martin   +10 more
doaj   +1 more source

Endothelial-Myocardial Angiocrine Signaling in Heart Development

Frontiers in Cell and Developmental Biology, 2021
Vascular endothelial cells are a multifunctional cell type with organotypic specificity in their function and structure. In this review, we discuss various subpopulations of endothelial cells in the mammalian heart, which spatiotemporally regulate ...
Hyeonyu Kim, Hyeonyu Kim, Mingqiang Wang, Mingqiang Wang, David T. Paik, David T. Paik   +5 more
doaj   +1 more source

Cardiomyocyte-specific deletion of Tead1 leads to early neonatal death by day 9 after birth.

, 2019
(A) Generation of Tead1 cardiomyocyte-specific knockout mice (Tead1-cKO) using knockout-first strategy: promoter-driven selection cassette. (B) Representative photograph of a Tead1-cKO breeding litter, demonstrating Tead1-cKO were born in Mendelian ...
Feng Li (30515), Rajaganapathi Jagannathan (104772), Byung S. Kim (3955703), Nikhil Balasubramanyam (6407207), Vijay K. Yechoor (389036), Mousumi Moulik (6407210), Ping Yang (56755), Jeongkyung Lee (389032), Ruya Liu (6407204)   +8 more
core   +1 more source

Data_Sheet_2_Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice.PDF [PDF]

, 2019
Cardiomyocyte proliferation accounts for the increase of cardiac muscle during fetal mammalian heart development. Shortly after birth, cardiomyocyte transits from hyperplasia to hypertrophic growth.
Brian N. Finck, Tani Leigh, Konstantinos Drosatos (5209304), Tongtong Cao, Daniela Liccardo (615764), Liccardo, Daniela, Zhang, Xiaoying, Tani Leigh (6498707), Cao, Tongtong, Drosatos, Konstantinos, Rong Lu, Ying Tian, Leigh, Tani, Lu, Rong, Xiongwen Chen, Chen, Xiongwen, Xiaoying Zhang, Konstantinos Drosatos, Daniela Liccardo, Brian N. Finck (106944), Finck, Brian N, Tian, Ying, Xiaoying Zhang (52883), Xiongwen Chen (316075), Rong Lu (53910), Tongtong Cao (6498701), Ryan LaCanna (6498704), Ryan LaCanna, Ying Tian (180972), LaCanna, Ryan   +29 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The cardiomyocyte cell cycle [PDF]

, 2006
Many forms of cardiac disease are characterized by cardiomyocyte death due to necrosis, apoptosis and/or oncosis. Recently, the notion of promoting cardiac regeneration as a means to replace damaged heart tissue has engendered considerable interest.
Lafontant, Pascal J.
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

A Computational Model for Cardiomyocytes Mechano-Electric Stimulation to Enhance Cardiac Tissue Regeneration

Mathematics, 2020
Electrical and mechanical stimulations play a key role in cell biological processes, being essential in processes such as cardiac cell maturation, proliferation, migration, alignment, attachment, and organization of the contractile machinery.
Pau Urdeitx, Mohamed H. Doweidar
doaj   +1 more source

In Vivo Methods to Monitor Cardiomyocyte Proliferation

, 2022
Adult mammalian cardiomyocytes demonstrate scarce cycling and even lower proliferation rates in response to injury. Signals that enhance cardiomyocyte proliferation after injury will be groundbreaking, address unmet clinical needs, and represent new ...
Matthew J. Wolf, Leigh A. Bradley, Alexander Young   +2 more
core   +1 more source

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo [PDF]

, 2022
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration.
Rackham, OJL, Cook, SA, Hardyman, Michelle A., Sheppard, MN, Sembrat, JC, Felkin, Leanne E, Cull, Joshua J, Meijles, Daniel N., Chothani, Sonia P, Clerk, A, McTiernan, CF, Cooper, Susanna TE, Felkin, Leanne E., Glennon, Peter E., Cook, Stuart A, Clerk, Angela, Alharbi, Hajed O, Alharbi, Hajed O., Sembrat, John C., Vanezis, K, Glennon, PE, Felkin, LE, Sugden, PH, Chothani, Sonia P., Cooper, Susanna T. E., Cook, Stuart A., Sugden, Peter H., McTiernan, Charles F, Fuller, Stephen J., Markou, T, Rojas, M, Cull, JJ, Leonard, SJ, McTiernan, Charles F., Rackham, Owen JL, Barton, Paul J., Cooper, STE, Sheppard, Mary N., Cull, Joshua J., Fuller, SJ, Hardyman, Michelle A, Barton, Paul J, Sheppard, Mary N, Fuller, Stephen J, Markou, Thomais, Rojas, Mauricio, Chothani, SP, Meijles, DN, Sembrat, John C, Barton, PJ, Shaw, SW, Sugden, Peter H, Meijles, Daniel N, Shaw, Spencer W, Leonard, Samuel J., Rackham, Owen J. L., Hardyman, MA, Glennon, Peter E, Alharbi, HO, Shaw, Spencer W., Leonard, Samuel J, Vanezis, Konstantinos   +61 more
core   +1 more source