Results 11 to 20 of about 103,439 (265)

Role of Phosphodiesterase 1 in the Regulation of Real-Time cGMP Levels and Contractility in Adult Mouse Cardiomyocytes

Cells, 2023
In mouse cardiomyocytes, the expression of two subfamilies of the calcium/calmodulin-regulated cyclic nucleotide phosphodiesterase 1 (PDE1)—PDE1A and PDE1C—has been reported. PDE1C was found to be the major subfamily in the human heart.
Nadja I. Bork, Hariharan Subramanian, Roberta Kurelic, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +4 more
doaj   +1 more source

The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts [PDF]

, 2011
The response of transverse (T)-tubules to exercise training in health and disease remains unclear. Therefore, we studied the effect of exercise training on the density and spacing of left ventricle cardiomyocyte T-tubules in normal and remodeled hearts ...
Kemi, Ole J., Wisloff, Ulrik, Koch, Lauren G., Morten A. Hoydal, MacQuaide, Niall, Haram, Per M., Godfrey L. Smith, Steven L. Britton, Hoydal, Morten A., Smith, Godfrey L., Ellingsen, Oyvind, Per M. Haram, Lauren G. Koch, Oyvind Ellingsen, Britton, Steven L., Niall MacQuaide, Ole J. Kemi, Ulrik Wisloff   +17 more
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Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin Type 2 receptor [PDF]

, 2012
The counter-regulatory axis of the renin angiotensin system peptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a potential therapeutic target in cardiac remodelling, acting via the mas receptor.
Nicklin Stuart A., Almalik Abdulaziz, Bruno M D C Godinho, Flores-Muñoz Monica, Flores-Muñoz, M., Almalik, A., Nicklin, S.A., Monica Flores-Muñoz, Stuart A Nicklin, Abdulaziz Almalik, Godinho, B.M.D.C., Godinho Bruno M. D. C.   +11 more
core   +1 more source

Studies on solvent precipitation of levan synthesized using Bacillus subtilis MTCC 441

Heliyon, 2019
Levan is a water soluble biopolymer widely used in food, pharma, personal care and aquaculture industries. In this work, levan was synthesized by Bacillus subtilis MTCC 441 using sucrose as a sole carbon source.
Jothi Sailaja C.A. Chidambaram, Bhuvaneshwari Veerapandian, Kartik Kumar Sarwareddy, Krishna Priya Mani, Saravanan Ramiah Shanmugam, Ponnusami Venkatachalam   +5 more
doaj   +1 more source

Geranylgeranylacetone reduces cardiomyocyte stiffness and attenuates diastolic dysfunction in a rat model of cardiometabolic syndrome

Physiological Reports, 2023
Titin‐dependent stiffening of cardiomyocytes is a significant contributor to left ventricular (LV) diastolic dysfunction in heart failure with preserved LV ejection fraction (HFpEF).
Mark T. Waddingham, Vasco Sequeira, Diederik W. D. Kuster, Elisa Dal Canto, M. Louis Handoko, Frances S. deMan, Denielli daSilva Gonçalves Bós, Coen A. Ottenheijm, Shengyi Shen, Robbert J. van derPijl, Jolanda van derVelden, Walter J. Paulus, Etto C. Eringa   +12 more
doaj   +1 more source

Cardiomyocyte-specific postnatal overexpression of p38γ/δ^act causes cardiac eccentric hypertrophy and heart dysfunction.

, 2021
(A) Immunoblot analysis of endogenous p38γ/δ in heart extracts from WT (non-injected) mice at PD 1, 3, 5, 7, 9, and 14. (B) Immunoblot using anti-FLAG antibody showing p38γ/δact specific cardiac overexpression at PD14 after AAV-cTnT-p38γ/δact injection ...
Jordi Duran (36345), María Villlalba-Orero (11675631), Daniel Jimenez-Blasco (11675616), Guadalupe Sabio (5487935), Francisco González-Romero (11675613), Rebeca Acín-Pérez (106137), Joan J. Guinovart (11675625), Ayelén M. Santamans (5487941), Cristina Casanueva-Benítez (11675622), Juan Antonio Lopez (11675610), Juan P. Bolaños (7953083), Jesús Jiménez-Borreguero (11675628), Alfonso Mora (335370), Jesús Vázquez (54003), Aránzazu Pintor-Chocano (11675619), Valle Montalvo-Romeral (11675607), Elena Rodríguez (2513533), José Antonio Enríquez (9446609), Luis Leiva-Vega (5487962), Patricia Aspichueta (9178163), Bárbara González-Terán (11675634)   +20 more
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Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication

Frontiers in Physiology, 2014
Most studies of the heart focus on cardiomyocytes (CM) at the exclusion of other cell types such as myocardial endothelial cells (EC). Such mono-cellular approaches propagate the presumption that EC provide a mere passive lining or supportive role.
Thorsten M. Leucker, Steven P. Jones
doaj   +1 more source

LncRNA CAIF suppresses LPS‐induced inflammation and apoptosis of cardiomyocytes through regulating miR‐16 demethylation

Immunity, Inflammation and Disease, 2021
Background The long noncoding RNA, cardiac autophagy inhibitory factor (CAIF), and microRNA (miR)‐16 are reported to be involved in lipopolysaccharide (LPS)‐induced inflammatory responses and cell apoptosis in many diseases.
Yan Wang, Yi Zhang
doaj   +1 more source

A multiscale computational model of spatially resolved calcium cycling in cardiac myocytes: from detailed cleft dynamics to the whole cell concentration profiles

Frontiers in Physiology, 2015
Mathematical modelling of excitation-contraction coupling (ECC) in ventricular cardiac myocytes is a multiscale problem, and it is therefore difficult to develop spatially detailed simulation tools. ECC involves gradients on the length scale of 100 nm in
Janine eVierheller, Wilhelm eNeubert, Martin eFalcke, Stephen Henry Gilbert, Nagaiah eChamakuri   +4 more
doaj   +1 more source

Chamber-Specific Protein Expression during Direct Cardiac Reprogramming

Cells, 2021
Forced expression of core cardiogenic transcription factors can directly reprogram fibroblasts to induced cardiomyocyte-like cells (iCMs) in vitro and in vivo. This cardiac reprogramming approach provides a proof of concept for induced heart regeneration
Zhentao Zhang, Jesse Villalpando, Wenhui Zhang, Young-Jae Nam   +3 more
doaj   +1 more source