Results 91 to 100 of about 146,196 (353)

Compartmentation of cAMP in Cardiomyocytes [PDF]

, 2010
The second messenger cAMP is responsible for β-adrenergic receptor (-AR) stimulation of cardiac function by catecholamines, but is also elevated in response to several other receptors which exert distinct functional effects on the heart. Evidences that spatial segregation of cAMP signalling may explain these observations are reviewed in this chapter ...
Vandecasteele, Grégoire, Fischmeister, Rodolphe   +1 more
openaire   +2 more sources

Understanding greater cardiomyocyte functions on aligned compared to random carbon nanofibers in PLGA

, 2014
Abdullah M Asiri,1 Hadi M Marwani,1 Sher Bahadar Khan,1 Thomas J Webster1,2 1Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Chemical Engineering, Northeastern University, Boston, MA,
Khan SB, Asiri AM, Marwani HM, Webster TJ   +3 more
core  

Cardiomyocyte remodeling in ischemic heart disease

, 2008
Objective. The aim of the study was to detect changes in left ventricular cardiomyocyte size and shape in response to chronic ischemia and loss of cardiac tissue (myocardial infarction) during the course of ischemic heart disease (IHD).
Elena Stalioraitytė, Reda Žiuraitienė, Danutė Kazlauskaitė, Ingrida Balnytė, Jolita Palubinskienė, Dalia Pangonytė   +5 more
core   +1 more source

Stereological estimation of cardiomyocyte number and proliferation

, 2021
Cardiovascular diseases remain the leading cause of death, largely due to the limited regenerative capacity of the adult mammalian heart. Yet, neonatal mammals were shown to regenerate the myocardium after injury by increasing the proliferation of pre ...
Sampaio-Pinto, Vasco, Nascimento, Diana S., Laundos, Tiago L., Martins, Paula da Costa, Silva, Elsa D., Pinto-do-O, Perpetua   +5 more
core   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Mammalian STE20-Like Kinase 2 Promotes Lipopolysaccharides-Mediated Cardiomyocyte Inflammation and Apoptosis by Enhancing Mitochondrial Fission

Frontiers in Physiology, 2020
In this study, we analyzed the role of mammalian STE20-like protein kinase 2 (Mst2), a serine-threonine protein kinase, in Lipopolysaccharides (LPS)-mediated inflammation and apoptosis in the H9C2 cardiomyocytes.
Yanan Tian, Haijiu Song, Wei Qin, Zhenjiang Ding, Ying Zhang, Weichao Shan, Dapeng Jin   +6 more
doaj   +1 more source

Pioglitazone Induces Cardiomyocyte Apoptosis and Inhibits Cardiomyocyte Hypertrophy Via VEGFR-2 Signaling Pathway

, 2018
Background: Pioglitazone has been widely used as an insulin-sensitizing agent for improving glycemic control in patients with type 2 diabetes mellitus. However, cardiovascular risk and protective effects of pioglitazone remain controversial. Objectives:
Xu,Shanghua, Wenliang Zhong, Yanqing Wu, Minlie Liang, Chen,Lianglong, Shanghua Xu (4002944), Yanqing Wu (582089), Wu,Yanqing, Shanghua Xu, Zhong,Wenliang, Wenliang Zhong (5715965), Luo,Shunxiang, Shunxiang Luo (5715974), Liang,Minlie, Shunxiang Luo, Minlie Liang (5715977), Wen Jin, Lianglong Chen (5715980), Wen Jin (160554), Lianglong Chen, Jin,Wen   +20 more
core   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Novel, low-cost bioreactor for in vitro electrical stimulation of cardiac cells

Frontiers in Bioengineering and Biotechnology
IntroductionThe successful implantation of laboratory-grown cardiac tissue requires phenotypically mature cardiomyocytes capable of electrophysiological integration with native heart tissue.
Joseph P. Licata, Jonathan A. Gerstenhaber, Peter I. Lelkes   +2 more
doaj   +1 more source

Cardiomyocyte differentiation: Experience and observations from 2 laboratories

SA Heart Journal, 2017
The undifferentiated clonal cell line, H9c2, derived from left ventricular rat heart tissue, has been extensively used in cardiovascular research. In the present study, 2 independent laboratories aimed to investigate the cells’ capacity to differentiate ...
Patten, V. A. , Chabaesele, I. , Sishi,B. , van Vuuren, D.   +3 more
doaj   +1 more source