Results 91 to 100 of about 103,439 (265)

MicroRNA-21 Mediates the Protective Effect of Cardiomyocyte-Derived Conditioned Medium on Ameliorating Myocardial Infarction in Rats

Cells, 2019
Conditioned medium derived from ischemic myocardium improves rodent cardiac function after myocardial infarction. Exosomal miRNA-mediated intercellular communication is considered to mediate the protective effect of conditioned medium against ischemic ...
Chih-Hung Chen, Shu-Yuan Hsu, Chien-Chih Chiu, Steve Leu   +3 more
doaj   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Myocardial composition and contractile function of right atrial trabeculae from type 2 diabetic and nondiabetic male patients

Physiological Reports
Diabetes impairs myocardial function. This study investigates tissue composition and contractile function of isolated atrial tissue from type 2 diabetic patients prior to heart failure.
Liam Tianlang Zhang, Amelia Sally Power, Nicholas Kang, Marie‐Louise Ward   +3 more
doaj   +1 more source

The cardiomyocyte cell cycle

, 2006
Many forms of cardiac disease are characterized by cardiomyocyte death due to necrosis, apoptosis and/or oncosis. Recently, the notion of promoting cardiac regeneration as a means to replace damaged heart tissue has engendered considerable interest.
Lafontant, Pascal J.
core  

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

Tead1 is required for perinatal cardiomyocyte proliferation

, 2019
Adult heart size is determined predominantly by the cardiomyocyte number and size. The cardiomyocyte number is determined primarily in the embryonic and perinatal period, as adult cardiomyocyte proliferation is restricted in comparison to that seen ...
Feng Li (30515), Rajaganapathi Jagannathan (104772), Byung S. Kim (3955703), Nikhil Balasubramanyam (6407207), Vijay K. Yechoor (389036), Mousumi Moulik (6407210), Ping Yang (56755), Jeongkyung Lee (389032), Ruya Liu (6407204)   +8 more
core   +1 more source

Revisiting Preadolescent Cardiomyocyte Proliferation in Mice. [PDF]

, 2016
Understanding cardiomyocyte cell cycle regulation after birth is key to optimizing regenerative strategies for the heart post-injury, yet poses multiple technical challenges, as evidenced by recent studies that have arrived at divergent conclusions. In a
Hirai, Maretoshi, Cattaneo, Paola, Chen, Ju, Evans, Sylvia M   +3 more
core   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Cardiomyocyte‐Specific Overexpression of Activated Yes‐Associated Protein Modified‐RNA Promotes Cardiomyocyte Proliferation and Myocardial Regeneration

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The proliferative capacity of cardiomyocytes in adult mammalian hearts is far too low to replace the cells that are lost to myocardial infarction.
Yongyu Wang, Yalin Wu, Yu Jiang, Huilan Tan, Bijay Guragain, Thanh Nguyen, Jianli Zhao, Yang Zhou, Yuji Nakada, Jianyi Zhang   +9 more
doaj   +1 more source

Mechanisms of greater cardiomyocyte functions on conductive nanoengineered composites for cardiovascular applications

, 2012
David A Stout,1,2 Jennie Yoo,2 Adriana Noemi Santiago-Miranda,3 Thomas J Webster1,41School of Engineering, 2Division of Biology and Medicine, Brown University, Providence, RI, 3Department of Chemical Engineering, University of Puerto Rico, Mayagü
Stout DA, Yoo J, Noemi Santiago-Miranda A, Webster TJ   +3 more
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