Results 111 to 120 of about 146,196 (353)

Na+/H+ exchanger isoform 1-induced osteopontin expression facilitates cardiomyocyte hypertrophy

, 2015
Enhanced expression and activity of the Na+/H+ exchanger isoform 1 (NHE1) has been implicated in cardiomyocyte hypertrophy in various experimental models.
Gadeau, Alain-Pierre, Lopaschuk, Gary, Filmore, Natasha, Abdulrahman, Nabeel, Mlih, Mohamed, Fliegel, Larry, Mraiche, Fatima, Mohamed, Iman A.   +7 more
core   +1 more source

Challenges measuring cardiomyocyte renewal [PDF]

, 2013
Interventions to effect therapeutic cardiomyocyte renewal have received considerable interest of late. Such interventions, if successful, could give rise to myocardial regeneration in diseased hearts.
Rubart, Michael, Field, Loren J., Soonpaa, Mark H.   +2 more
core   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Molecular Communications For Cardiomyocytes

39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2017
The continued miniaturization of electronics makes it realistic to monitor internal cardiac disease processes by wireless implantable medical sensors and actuators incorporated in implantable cardiac devices. In order to deal with some cardiac diseases, this paper introduces the molecular communication methods for cardiac muscle cell communications.
Lu, Pengfei, Pritam, Bose, Mohammad, Albatat, Ilangko, Balasingham   +3 more
openaire   +2 more sources

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

MicroRNA-21 Mediates the Protective Effect of Cardiomyocyte-Derived Conditioned Medium on Ameliorating Myocardial Infarction in Rats

Cells, 2019
Conditioned medium derived from ischemic myocardium improves rodent cardiac function after myocardial infarction. Exosomal miRNA-mediated intercellular communication is considered to mediate the protective effect of conditioned medium against ischemic ...
Chih-Hung Chen, Shu-Yuan Hsu, Chien-Chih Chiu, Steve Leu   +3 more
doaj   +1 more source

Human Ventricular Unloading Induces Cardiomyocyte Proliferation [PDF]

, 2015
BackgroundThe adult mammalian heart is incapable of meaningful regeneration after substantial cardiomyocyte loss, primarily due to the inability of adult cardiomyocytes to divide.
Garg, Sonia, Kimura, Wataru, Abdisalaam, Salim, Asaithamby, Aroumougame, Canseco, Diana C., Mukherjee, Shibani, Das, Sandeep, Bhattacharya, Souparno, Sadek, Hesham A., Mammen, Pradeep P.A.   +9 more
core   +1 more source

Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics

Advanced Science, EarlyView.
The mammalian lung contains ∼50 cell types arranged along the airway epithelium. Here, deterministic barcoding sequencing (DBiT‐seq) is optimized to nearly double transcript recovery, enabling highly sensitive spatial mapping of the embryonic mouse lung.
Pengfei Zhang, Benjamin K. Law, Niles Huang, Katharine Goodwin, Celeste M. Nelson, Michelle M. Chan   +5 more
wiley   +1 more source

Myocardial composition and contractile function of right atrial trabeculae from type 2 diabetic and nondiabetic male patients

Physiological Reports
Diabetes impairs myocardial function. This study investigates tissue composition and contractile function of isolated atrial tissue from type 2 diabetic patients prior to heart failure.
Liam Tianlang Zhang, Amelia Sally Power, Nicholas Kang, Marie‐Louise Ward   +3 more
doaj   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source