Results 121 to 130 of about 146,196 (353)

Cardiomyocytes remuscularize the heart

Nature Biotechnology, 2018
The contractility of the infarcted macaque heart is repaired by cardiomyocytes derived from human embryonic stem cells.
openaire   +3 more sources

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Cardiomyocyte Renewal [PDF]

New England Journal of Medicine, 2009
Michael S, Parmacek, Jonathan A, Epstein
openaire   +2 more sources

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Application of Digital Holographic Imaging to Monitor Real-Time Cardiomyocyte Hypertrophy Dynamics in Response to Norepinephrine Stimulation

Applied Sciences
Cardiomyocyte hypertrophy, characterized by an increase in cell size, is associated with various cardiovascular diseases driven by factors including hypertension, myocardial infarction, and valve dysfunction. In vitro primary cardiomyocyte culture models
Wahida Akter, Herman Huang, Jacquelyn Simmons, Alexander Y. Payumo   +3 more
doaj   +1 more source

Mechanisms of greater cardiomyocyte functions on conductive nanoengineered composites for cardiovascular applications

, 2012
David A Stout,1,2 Jennie Yoo,2 Adriana Noemi Santiago-Miranda,3 Thomas J Webster1,41School of Engineering, 2Division of Biology and Medicine, Brown University, Providence, RI, 3Department of Chemical Engineering, University of Puerto Rico, Mayagü
Stout DA, Yoo J, Noemi Santiago-Miranda A, Webster TJ   +3 more
core  

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Tead1 is required for perinatal cardiomyocyte proliferation

, 2019
Adult heart size is determined predominantly by the cardiomyocyte number and size. The cardiomyocyte number is determined primarily in the embryonic and perinatal period, as adult cardiomyocyte proliferation is restricted in comparison to that seen ...
Feng Li (30515), Rajaganapathi Jagannathan (104772), Byung S. Kim (3955703), Nikhil Balasubramanyam (6407207), Vijay K. Yechoor (389036), Mousumi Moulik (6407210), Ping Yang (56755), Jeongkyung Lee (389032), Ruya Liu (6407204)   +8 more
core   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Heart weight and cardiomyocyte size.

, 2015
Left ventricle thickness (panel B) and cardiomyocyte size (panel D) were markedly increased in D2 mice compared to B6 mice (panels A and C, respectively).
Yuanjian Chen (779441), Tieqiang Zhao (779440), Yao Sun (145327), Wenyuan Zhao (385511), Fengbo Zhao (779442), Lu Lu (392), Qingqing Gu (338902), Syamal K. Bhattacharya (779443), Robert W. Williams (10394)   +8 more
core   +1 more source