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Heart Failure Clinics, 2005
Heart failure is a syndrome that arises primarily from a loss of power of the contracting muscle of the heart. Genetic studies have shown that some ‘‘idiopathic’’ dilated cardiomyopathies are caused by a defect in the individual muscle units of the heart (cardiomyocytes), such as a mutation in the proteins of the sarcomere, which leads directly to poor
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Heart failure is a syndrome that arises primarily from a loss of power of the contracting muscle of the heart. Genetic studies have shown that some ‘‘idiopathic’’ dilated cardiomyopathies are caused by a defect in the individual muscle units of the heart (cardiomyocytes), such as a mutation in the proteins of the sarcomere, which leads directly to poor
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Cardiomyocyte cytokinesis score: a potential method for cardiomyocyte proliferation
Cell Biology International, 2014AbstractOne of the most important indicators of myocardial regeneration is cardiomyocyte proliferation. However, it is difficult to distinguish cardiomyocytes in the regenerating stage from binucleated or multinucleated myocytes by conventional morphometric techniques.
Kun, Hua +4 more
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Glycation in the cardiomyocyte
Glycation is a protein post-translational modification that can occur on lysine and arginine residues as a result of a non-enzymatic process known as the Maillard reaction. This modification is irreversible, so the only way it can be removed is by protein degradation and replacement.Christine E, Delligatti +1 more
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Microtopographical assembly of cardiomyocytes
Integrative Biology, 2011One of the central challenges in cardiac tissue engineering is the control of the assembly and organization of functional cardiac tissue. Maintenance of a three-dimensional tissue architecture is key to myocardial function in vivo, and a variety of studies hint that provision of topological cues within scaffolds can facilitate the engineering of ...
Anuj A, Patel +2 more
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Isolation and Differentiation of Human Cardiomyocyte Progenitor Cells into Cardiomyocytes
2012To date, there is no suitable in vitro model to study human adult cardiac cell biology. Here, we describe a method for efficient isolation and expansion of human cardiomyocyte progenitor cells (CMPCs) from cardiac surgical waste or, alternatively, from fetal heart tissue.
Anke M, Smits +2 more
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Cryopreservation of Neonatal Cardiomyocytes
2015Cardiomyocytes are frequently used for in vitro models for cardiac research. The isolation of cells is time-consuming and, due to the cells limited proliferative abilities, must be performed frequently. To reduce the time requirements and the impact on research animals, we describe a method for cryopreserving neonatal rat cardiomyocytes (NRCMs), and ...
Adam C, Vandergriff +2 more
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Pathophysiology of Cardiomyocytesa
Annals of the New York Academy of Sciences, 1988Isolated cardiomyocytes lend themselves very well to the quantification of pathological damage and to the determination of reversible versus irreversible changes. These single cells were used to study the cellular response to a variety of pathologic stimuli that impair structure and function.
M, Borgers +2 more
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The genetics of cardiomyocyte polyploidy
The regulation of ploidy in cardiomyocytes is a complex and tightly regulated aspect of cardiac development and function. Cardiomyocyte ploidy can range from diploid (2N) to 8N or even 16N, and these states change during key stages of development and disease progression.Tyler, Buddell +2 more
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Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling
Proceedings of the National Academy of Sciences of the United States of America, 2021Isha Sethi, Eric Small, Alan H Beggs
exaly