Results 151 to 160 of about 1,506,940 (201)
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Scaffold evaluation of liguzinediol analogs as novel cardiotonic agents
Die Pharmazie, 2013Liguzinediol (LZDO) could mediate the positive inotropic effects through sarcoplasmic reticulum Ca2+ ATPase-dependent mechanism without the risk of arrhythmia. However, the pharmacophore of LZDO contributed to the activities was not clear. The aim of this work was to explore the relationship between positive inotropic effect and scaffold of LZDO as ...
Liu, Z. +8 more
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Analysis of the efficacy of the new cardiotonic agent TA-064
American Heart Journal, 1985TA-064 is a new cardiotonic agent which is also effective orally, according to investigations conducted in Japan. We analyzed computer-assisted alterations of pressure-volume relationships serially and of indirect myocardial oxygen consumption (MVO2) estimations on line during TA-064 influence in 16 patients with congestive cardiomyopathy: left ...
J, Thormann +5 more
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Cardiovascular Properties of a New Cardiotonic Agent, MDL 19205
Journal of Cardiovascular Pharmacology, 1984The cardiovascular properties of a new cardiotonic agent, MDL 19205, were investigated in anesthetized and conscious dogs and in a dog heart-lung preparation. MDL 19205 (0.1-1 mg/kg), administered to anesthetized dogs by intravenous injection, produced a dose-related increase in cardiac contractile force lasting up to 1 h. It also produced a relatively
R C, Dage +3 more
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Cardiotonic Agent SCH00013 Prolongs Survival of Cardiomyopathic Hamsters
Journal of Cardiovascular Pharmacology, 2003The authors examined the effects of long-term treatment with SCH00013, a novel cardiotonic agent with calcium-sensitizing action, on survival of hereditary cardiomyopathic BIO 14.6 hamsters. Sixty-nine male hamsters at 223 days of age were divided into untreated, SCH00013-low (approximately 1 mg/kg/d), and SCH00013-high (approximately 10 mg/kg/d ...
Tadahito, Narita +4 more
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Annales de cardiologie et d'angeiologie, 1986
The possibilities for therapy in the field of severe cardiac insufficiency have been extended in recent years by the introduction of novel agents endowed with a positive inotropic action. These substances may be arranged in two large classes: sympathomimetic agents and "non sympathomimetic--non digitalis-like" inotropic agents.
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The possibilities for therapy in the field of severe cardiac insufficiency have been extended in recent years by the introduction of novel agents endowed with a positive inotropic action. These substances may be arranged in two large classes: sympathomimetic agents and "non sympathomimetic--non digitalis-like" inotropic agents.
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[Membranotropic action of cardiotonic agents and ubiquinone].
Ukrainskii biokhimicheskii zhurnal (1978), 1991Interaction of cardiotonic drugs (strophantidine acetate, suphan, para-oxybenzoic acid) and ubiquinone with phospholipid bilayers has been studied. Exothermic effect of the reaction followed by an increase in microviscosity and hydrophobicity of the bilayer from cardiolipin, but by a decrease of the microviscosity of the bilayer from lecithin has been ...
I S, Chekman +3 more
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Calcium Signaling and Pharmacology of Cardiotonic Agents
1995The mechanisms of action of drugs that act on myocardial contractility through different signal transduction pathways have lately been elucidated to a great extent, in particular since the introduction of novel methods for detecting changes in the intracellular concentration of Ca++ ions, ([Ca++] i), by the application of aequorin, quin-2, fura-2 and ...
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[Value and limitations of new cardiotonic agents].
Bulletin de l'Academie nationale de medecine, 1989New cardiotonic agents are an original approach in the treatment of severe heart failure. They can be classified into two groups: --beta-adrenergic agonists which stimulate beta-adrenergic receptors and, therefore, increase cyclic AMP production and intracellular calcium concentration; --phosphodiesterase inhibitors which block the cyclic AMP ...
Y, Grosgogeat, M, Komajda
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Inosine : a naturally occurring cardiotonic agent.
Journal de pharmacologie, 1984For many years, Inosine was considered to be a simple metabolite of adenosine which was devoid of any cardiovascular effects. This theoretical ineffectiveness can be explained in the light of recent studies by the use of inadequate doses. In fact, higher doses of inosine, a non-toxic nucleoside, have demonstrated, experimentally, a cardiovascular ...
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