Results 161 to 170 of about 43,976 (245)

In silico predictions of action potential propagation in doxorubicin cardiotoxicity: A parametric study using preclinical 3D magnetic resonance imaging‐based fibrotic left ventricle models

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the study's methodology and key findings. In a preclinical swine model, doxorubicin administration induced cardiotoxicity, characterized by diffuse fibrotic remodelling and altered electrical function, as assessed by magnetic resonance (MR) imaging and electrophysiological mapping.
Javier Villar‐Valero, Jairo Rodríguez Padilla, Nicolas Cedilnik, Buntheng Ly, Juan F. Gomez, Maxime Sermesant, Mihaela Pop, Beatriz Trenor   +7 more
wiley   +1 more source

Sarcolemmal and mitochondrial membrane potentials measured ex vivo and in vivo in the heart by pharmacokinetic modelling of [99mTc]sestamibi

The Journal of Physiology, EarlyView.
Abstract figure legend The pharmacokinetics of lipophilic cationic radiotracers such as [99mTc]sestamibi and [99mTc]tetrofosmin are dependent on the electrical potentials that determine their distribution across the sarcolemmal and mitochondrial membranes.
Edward C. T. Waters, Friedrich Baark, Matthew R. Orton, Michael J. Shattock, Richard Southworth, Thomas R. Eykyn   +5 more
wiley   +1 more source

Antihypertensive Past Adherence Trajectories and Risk of Cardiotoxicity Among Adults Initiating Anthracycline Treatment. [PDF]

Pharmacoepidemiol Drug Saf
Damachi U, Onukwugha E, Mysore MM, Camelo Castillo W.   +3 more
europepmc   +1 more source

CRISPR/Cas9 Screens Implicate RARA and SPNS1 in Doxorubicin Cardiotoxicity. [PDF]

JACC CardioOncol
McDermott-Roe C, Lv W, Shao Y, Hoshino A, Arany Z, Musunuru K.   +5 more
europepmc   +1 more source

Age‐ and sex‐specific modulation of human cardiac electrophysiology by doxorubicin

The Journal of Physiology, EarlyView.
Abstract figure legend DOX differentially impacts cardiac electrophysiology based on sex and age. Sex differences were primarily observed among younger hearts, where action potential duration (APD) prolongation was observed in females, but not in males. Created using BioRender. George, S. (2026) https://BioRender.com/wresf1k Abstract Acute doxorubicin (
Sharon A. George, Amber V. Mills, Erin O'Neill, Sofian N. Obaid, Igor R. Efimov, Tatiana Efimova   +5 more
wiley   +1 more source

Serinc2-STAT3 protects against doxorubicin-induced cardiotoxicity via promoting mitochondrial bioenergetics. [PDF]

Redox Biol
Hu S, Yang M, Liu T, Huang M, Ju H, Liu Z, Kashkooli S, Cheng M, Wu G.   +8 more
europepmc   +1 more source

Myocardial toxicity in two dogs with natural exposure to ractopamine

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract Two dogs that lived in a farm setting were presented to the Texas A&M University Veterinary Medical Teaching Hospital's Emergency Service exhibiting muscle tremors and ventricular arrhythmias following ingestion of ractopamine, a ß‐2 agonist feed‐additive used in beef cattle, pigs and turkeys intended for slaughter to increase muscle mass. The
Sophie Tippit, Igor Yankin, Molly Wart, Sonya Wesselowski   +3 more
wiley   +1 more source

Characterizing Parental Concerns About Lasting Impacts of Treatment in Children With B‐Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.
ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker, Sarah W. Alexander, Lisa M. Jacola, Kimberly A. Buff, Kyobin Hwang, Elham Hashemi, Gregory Stoddard, Lindsay A. Jibb   +7 more
wiley   +1 more source

Heartbreakers and healers: RNA rebels in cardio-oncology. [PDF]

Semin Cancer Biol
Agyemang-Dua C, Chung CS, Espinosa-Diez C.   +2 more
europepmc   +1 more source