Results 161 to 170 of about 97,116 (340)

Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors

Medicinal Research Reviews, EarlyView.
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara, Gómez‐Santacana Xavier, Llebaria Amadeu, Rovira Xavier   +3 more
wiley   +1 more source

Abietic Acid Enhances the Sedative Activity of Diazepam: In vivo Approach along with Receptor Binding Affinity and Molecular Interaction with the GABAergic System

ChemistryOpen, EarlyView.
Abietic acid (AA) reveals potent sedative potential by expressing fast sleeping onset and increased sleeping duration compare to the control group in thiopental sodium induced sleeping mice. The compound also exhibited notable binding affinity (–7.9 kcal/mol) toward GABAA receptors.
Meher Afroz, Rubel Hasan, Mst Muslima Khatun, Mokammel Hossain Tito, Md Shadin, Ranjit Chakma, Mohammed Asiri, Faisal H. Altemani, Abdullah H. Altemani, Md Shimul Bhuia, Muhammad Torequl Islam   +10 more
wiley   +1 more source

An intelligent biosensing platform using phase space reconstruction‐assisted convolutional neural network for drug‐induced cardiotoxicity assessment

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Drug‐induced cardiotoxicity often leads to patient deaths and drug recalls. Interdigitated electrode (IDE)‐based cellular impedance detection instrument has been integrated with intelligent algorithms to screen cardiotoxicity based on cardiomyocytes ...
Wenjian Yang, Xinyu Guo, Ruochen Wu, Yue Wu, Minzhi Fan, Bihu Lv, Diming Zhang, Zhijing Zhu   +7 more
doaj   +1 more source

Cell-Permeable Microprotein from Panax Ginseng Protects Against Doxorubicin-Induced Oxidative Stress and Cardiotoxicity [PDF]

Bamaprasad Dutta, Shining Loo, Antony Kam, Xiaoliang Wang, Na Wei, Kathy Qian Luo, Chuan‐Fa Liu, James P. Tam   +7 more
openalex   +1 more source

CMR reveals myocardial damage from cardiotoxic oncologic therapies in breast cancer patients [PDF]

, 2023
Johannes Kersten, Visnja Fink, M. J. Kersten, Lisa May, Samuel Nunn, Marijana Tadić, Jens Huober, Inga Bekes, Michael Radermacher, Vinzenz Hombach, Eckhard Wolf, Dominik Buckert   +11 more
openalex   +1 more source

Rib Ewing Sarcomas in Children and Young Adults: A Large National Retrospective Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Purpose Ewing sarcoma (ES) is the most prevalent malignant thoracic tumor in childhood and young adults. This study reports the outcome of a national cohort treated in an international prospective trial for a localized rib ES, with a long follow‐up.
Audrey Claren, Alexandre Beige, Magali Morelle, Jérôme Doyen, Cyril Lervat, Luc Ollivier, Cécile Vérité, Perrine Marec‐Bérard, Maria Jolnerovski, Anne Ducassou, Valentine Martin, Line Claude, French Multidisciplinary Working Group on Bone Primary Tumours (GROUPOS), GSF (French Sarcoma Group), GETO (Bone Tumour Study Group) and SFCE (French Society for the Fight against Childhood and Adolescent Cancer and Leukaemia)   +14 more
wiley   +1 more source

Identification of Fertile Translations in Medical Comparable Corpora: a Morpho-Compositional Approach [PDF]

, 2012
This paper defines a method for lexicon in the biomedical domain from comparable corpora. The method is based on compositional translation and exploits morpheme-level translation equivalences.
Daille, Béatrice, Delpech, Estelle, Lemaire, Claire, Morin, Emmanuel   +3 more
core   +3 more sources

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

The pediatric oncology exercise field speeds up to address important issues regarding chemotherapy-related cardiotoxicity [PDF]

, 2022
Maxime Caru, Daniel Curnier
openalex   +1 more source

Lithospermic Acid Improves Doxorubicin‐Induced Cardiomyopathy Through Sirtuin‐3‐Mediated Deacetylation of p53

Phytotherapy Research, EarlyView.
Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao, Tao Xu, Chao Ye, Ke Zhang, Xinyu Heng, Shaohong Huang, Yan Chen, Yitong Guo, Shengyi Shao, Zhi Wen, Chenwen Shao, Xiang Lu, Ning Sun, Hai Yang   +13 more
wiley   +1 more source