Results 141 to 150 of about 119,936 (354)

New patents on topical anesthetics. [PDF]

open access: yes, 2014
Anesthesia is defined as a total or partial loss of sensation and it may be general, local or topical, depending on the method of drug administration and area of the body affected.
CALVIERI, Stefano   +6 more
core   +1 more source

Population pharmacokinetics and dose–response relationships of mitoxantrone in children with acute myeloid leukaemia

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Background Information on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data‐informed assessment of dosing.
Andrew M. Brandon   +13 more
wiley   +1 more source

The association between systemic immune-inflammation index and cardiotoxicity related to 5-Fluorouracil in colorectal cancer

open access: yesBMC Cancer
Background and aims The cardiotoxicity related to 5-Fluorouracil (5-FU) in cancer patients has garnered widespread attention. The systemic immune-inflammation index (SII) has recently been identified as a novel predictive marker for the development of ...
Xiaoqin Liu   +7 more
doaj   +1 more source

Identification of Fertile Translations in Medical Comparable Corpora: a Morpho-Compositional Approach [PDF]

open access: yes, 2012
This paper defines a method for lexicon in the biomedical domain from comparable corpora. The method is based on compositional translation and exploits morpheme-level translation equivalences.
Daille, Béatrice   +3 more
core   +3 more sources

Myocardial Function Maturation in Very-Low-Birth-Weight Infants and Development of Bronchopulmonary Dysplasia [PDF]

open access: yes, 2019
Background: Myocardial function in very-low-birth-weight infants (VLBWIs) develops during early postnatal life, but different patterns of temporal evolution that might be related to the development of bronchopulmonary dysplasia (BPD) are not completely ...
Benavente Fernández, Isabel   +3 more
core   +2 more sources

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

open access: yesBMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai   +14 more
wiley   +1 more source

Morphometric study of myocardial changes during doxorubicin-induced cardiomyopathy in mice [PDF]

open access: yes, 1988
Doxorubicin (DOX) is one of the most effective anti-cancer drugs in oncology, but may cause a cumulative dose-dependent cardiomyopathy in a number of cancer patients. The effect of DOX on the heart was studied in mice treated with i.v. injections of 2 mg/
Feijen, Jan   +6 more
core   +3 more sources

Environmental Transformation and Trophic Transfer of Engineered Nanomaterials in the Agri‐Food Chain and Implications for human Health

open access: yesChemFoodChem, EarlyView.
ABSTRACT Engineered nanomaterials (ENMs) are increasingly applied in agriculture to improve crop yield, nutrient efficiency, and food quality. This study examines the environmental transformation of ENMs, their uptake in plants, and their transfer across the agri‐food chain leading to human exposure.
Soumitra Nath
wiley   +1 more source

Evaluation of miR-146a as a potential biomarker for diagnosis of cardiotoxicity induced by chemotherapy in patients with breast cancer

open access: yesJournal of Research in Medical Sciences
Background: Cardiotoxicity from chemotherapy may result in cardiomyopathy and heart failure. Clinicians can use the evaluation of cardiotoxicity-specific biomarkers, such as microRNA, as a tool for the early detection of cardiotoxicity.
Nasrin Zare   +4 more
doaj   +1 more source

Evidence linking exposure of fish primary macrophages to antibiotics activates the NF-kB pathway. [PDF]

open access: yes, 2020
Low doses of antibiotics are ubiquitous in the marine environment and may exert negative effects on non-target aquatic organisms. Using primary macrophages of common carp, we investigated the mechanisms of action following exposure to several common ...
Chen, Qiqing   +8 more
core  

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