Results 141 to 150 of about 64,429 (258)

Antimicrobial Residues in a Key Cerrado River: Distribution, Persistence, and Effects on Zebrafish Embryo‐Larval Development

Environmental Toxicology, EarlyView.
ABSTRACT The current study aimed to quantify the antimicrobials amoxicillin (AMX), cefazolin (CFZ), chloramphenicol (CHL), metronidazole (MTZ), and sulfamethoxazole (SX) in effluents and surface water of an important Cerrado river, calculate their half‐lives, and analyze their ecotoxicity following single and combined exposures.
Náthala Maria Simão, Igor Romeiro dos Santos, Jerônimo Raimundo de Oliveira Neto, Flávio Olimpio Sanches Neto, Felipe Cirqueira Dias, Jéssyca Moreira Morais, Lorranny Pereira de Assis Valadares, Naiara Raica Lopes de Oliveira, Mirelle Garcia Silva Bailão, Luiz Carlos da Cunha, Valter Henrique Carvalho‐Silva, Thiago Lopes Rocha, Elisa Flávia Luiz Cardoso Bailão   +12 more
wiley   +1 more source

Environmentally Realistic Metal Mixture Concentration Impacts Early Development in Zebrafish Larvae

Environmental Toxicology, EarlyView.
ABSTRACT The dispersion of metals in the environment leads to the presence of metal mixtures in impacted ecosystems, but few studies have addressed their impact on early developmental processes in fish. Here, we investigated the effect of metal mixtures reported in the Doce River basin in Brazil, including Fe, Mn, and Cd, either singly or as a mixture ...
Anderson K. S. Macêdo, Willian A. Thompson, Hélio B. Santos, Ralph G. Thomé, Mathilakath M. Vijayan   +4 more
wiley   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

Genetic and Molecular Determinants of Cancer Therapy-Related Cardiovascular Toxicity. [PDF]

Cardiovasc Toxicol
Szubińska-Bałaban P, Klotzka A, Ziółkowska K, Marciniak-Stępak P, Niedzielska J, Russo F, Suleiman AA, Glista F, Kuczmarska A, Bukowska-Olech E.   +9 more
europepmc   +1 more source

Comparative Molecular Insights into Developmental and Behavioral Toxicity Induced by Octocrylene and Ethylhexyl Salicylate Exposure on Zebrafish

Integrative Zoology, EarlyView.
This study compared the ecological toxicity of organic ultraviolet filters, octocrylene (OC) and ethylhexyl salicylate (EHS), on zebrafish embryos and larvae. EHS exhibited higher acute toxicity, causing increased mortality, hypoactive behavior at 50 mg/L, and disruptions in lipid homeostasis, while OC primarily affected hypoxia response and ...
Xiaoyang Lu, Li Sun, Jiao Chen, Jing Wang, Miao Guan, Shixia Xu   +5 more
wiley   +1 more source

5-Fluorouracil (5-FU) Cardiotoxicity: A Stressful Event. [PDF]

Case Rep Cardiol
Desai Y, Singh R, Desai K, Bennett S, Desai R, Mysore M.   +5 more
europepmc   +1 more source

Superior Hypogastric Nerve Block in Uterine Artery Embolisation Protocols for Symptomatic Fibroids: An Australian Single‐Centre Experience

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Introduction Assessment of the safety of Superior Hypogastric Nerve Block (SHNB) in uterine artery embolisation (UAE) for symptomatic fibroids. Method Retrospective single tertiary centre analysis of patients who underwent UAE with SHNB (n = 40). Outcomes include assessment of pain scores, overnight stays and complications.
Nessa Kellegher, Jonathan Kelly, Gillian Kehoe, Kevin Ho, Gurjeet Dulku   +4 more
wiley   +1 more source

A Deep-Learning-Based Scoring Framework for Large-Scale Multi-donor Cardiotoxicity Screening. [PDF]

Comput Struct Biotechnol J
Vu D, Kowalczewski A, Burnett SD, Sakolish C, Liu X, Yang H, Rusyn I, Ma Z.   +7 more
europepmc   +1 more source

FGF21/sirtuin 1 axis mediates the cardioprotective effects of high-intensity interval training against doxorubicin-induced cardiotoxicity by reducing inflammatory and oxidative stress. [PDF]

Exp Physiol
Abstract Doxorubicin (DOX) is a potent anthracycline chemotherapeutic agent, but its clinical use is limited by cumulative cardiotoxicity. Exercise, particularly high‐intensity interval training (HIIT), has emerged as an effective non‐pharmacological strategy to counteract chemotherapy‐induced cardiac injury.
Farahani M, Gaeini AA, Ghardashi Afousi A, Borjian Fard M.   +3 more
europepmc   +2 more sources