Results 51 to 60 of about 97,116 (340)

A prelude report on molecular docking of HER2 protein towards comprehending anti-cancer properties of saponins from Solanum tuberosum [PDF]

, 2012
Saponins are extensively known for many biological activities e.g. antimicrobial, anti-palatability, anti-cancer and hemolytic. As cancer cells have a more cholesterol-like compound in their membrane structure the saponins bind cholesterol due to their ...
Pratyoosh Shukla, Puneet K. Singh
core   +2 more sources

A retrospective analysis of the association of obesity with anthracycline- and trastuzumab-induced cardiotoxicity in the treatment of breast cancer and lymphoma

Archives of Medical Science
Introduction Trastuzumab and anthracyclines are mainstays of chemotherapy in breast cancer and lymphoma patients but may cause significant cardiotoxicity, which may result in alterations to chemotherapy dose, schedule, or agent.
Mallorie L. Huff, Ranju Gupta, Rahul Gupta, Kelly C. Schadler, Shae Duka, Vienna Histon-Figliolini, Joshua Kalter, Amogh M. Joshi, Nadeem V. Ahmad, Wilbert S. Aronow, Deborah W. Sundlof   +10 more
doaj   +1 more source

Role of acetylation in doxorubicin-induced cardiotoxicity

Redox Biology, 2021
As a potent chemotherapeutic agent, doxorubicin (DOX) is widely used for the treatment of a variety of cancers However, its clinical utility is limited by dose-dependent cardiotoxicity, and pathogenesis has traditionally been attributed to the formation ...
Daisong Li, Yanyan Yang, Shizhong Wang, Xiangqin He, Meixin Liu, Baochen Bai, Chao Tian, Ruicong Sun, Tao Yu, Xianming Chu   +9 more
doaj   +1 more source

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Tumor detection and elimination by a targeted gallium corrole [PDF]

, 2009
Sulfonated gallium(III) corroles are intensely fluorescent macrocyclic compounds that spontaneously assemble with carrier proteins to undergo cell entry.
Agadjanian, Hasmik, Farkas, Daniel L., Gray, Harry B., Gross, Zeev, Hwang, Jae Youn, Ma, Jun, Mahammed, Atif, Medina-Kauwe, Lali K., Rentsendorj, Altan, Valluripalli, Vinod   +9 more
core   +3 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Cardiotoxicity with vascular endothelial growth factor inhibitor therapy [PDF]

, 2018
Angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signaling pathway (VSP) have been important additions in the therapy of various cancers, especially renal cell carcinoma and colorectal cancer.
Herrmann, Joerg, Touyz, Rhian M.
core   +2 more sources

Risk factors for fluorouracil-induced cardiotoxicity in patients with gastrointestinal tumor

Frontiers in Cardiovascular Medicine
ObjectiveTo explore the risk factors for cardiotoxicity in patients with gastrointestinal (GI) tumors treated with fluorouracil drugs.MethodsThis study included patients with GI tumors who received fluorouracil at our hospital between January 2018 and ...
Yuting Wu, Chen Lv, Jindong Li, Ying Ma, Xiaoli Zhu   +4 more
doaj   +1 more source

Acute and early-onset cardiotoxicity in children and adolescents with cancer: a systematic review

BMC Cancer, 2023
Background Cardiotoxicity is among the most important adverse effects of childhood cancer treatment. Anthracyclines, mitoxantrone and radiotherapy involving the heart are its main causes. Subclinical cardiac dysfunction may over time progress to clinical
Theodorus W. Kouwenberg, Elvira C. van Dalen, Elizabeth A. M. Feijen, Stejara A. Netea, Melissa Bolier, Martijn G. Slieker, Firdaus A. A. Mohamed Hoesein, Leontien C. M. Kremer, Heynric B. Grotenhuis, Annelies M. C. Mavinkurve-Groothuis   +9 more
doaj   +1 more source