Results 31 to 40 of about 119,936 (354)

Mitochondrial-Targeted Therapy for Doxorubicin-Induced Cardiotoxicity

International Journal of Molecular Sciences, 2022
Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment of cancer, but their clinical use is associated with severe and potentially life-threatening cardiotoxicity.
Bin Wu, K. Leung, E. Poon
semanticscholar   +1 more source

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.

JCI Insight, 2020
Doxorubicin (DOX), a chemotherapeutic agent, induces a cardiotoxicity referred to as doxorubicin-induced cardiomyopathy (DIC). This cardiotoxicity often limits chemotherapy for malignancies and is associated with poor prognosis.
T. Tadokoro, Masataka Ikeda, T. Ide, Hiroko Deguchi, S. Ikeda, Kosuke Okabe, Akihito Ishikita, Shouji Matsushima, T. Koumura, Ken‐ichi Yamada, H. Imai, H. Tsutsui   +11 more
semanticscholar   +1 more source

Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages

Journal of experimental & clinical cancer research : CR, 2022
Immune checkpoint inhibitor-related cardiotoxicity is one of the most lethal adverse effects, and thus, the identification of underlying mechanisms for developing strategies to overcome it has clinical importance.
Yaxin Chen, Yanzhuo Liu, Yang Wang, Xuewei Chen, Chenlong Wang, Xue-Wen Chen, Xiyu Yuan, Lilong Liu, Jing Yang, Xiaoyang Zhou   +9 more
semanticscholar   +1 more source

Bibliometric and visual analysis of doxorubicin-induced cardiotoxicity

Frontiers in Pharmacology, 2023
Background: Doxorubicin-induced cardiotoxicity represents a prevalent adverse effect encountered in patients undergoing treatment with doxorubicin. To date, there has been no bibliometric study to summarize the field of doxorubicin-induced cardiotoxicity.
Xiaoxiao Lin, Guomin Wu, Shuai Wang, Jinyu Huang   +3 more
doaj   +1 more source

Human Pluripotent Stem Cells for Modeling of Anticancer Therapy-Induced Cardiotoxicity and Cardioprotective Drug Discovery

Frontiers in Pharmacology, 2021
Anticancer chemotherapies have been shown to produce severe side effects, with cardiotoxicity from anthracycline being the most notable. Identifying risk factors for anticancer therapy-induced cardiotoxicity in cancer patients as well as understanding ...
Wendy Keung, Yiu-Fai Cheung, Yiu-Fai Cheung   +2 more
doaj   +1 more source

Cardiotoxicity of Anticancer Drugs: Molecular Mechanisms and Strategies for Cardioprotection

Frontiers in Cardiovascular Medicine, 2022
Chemotherapy and targeted therapies have significantly improved the prognosis of oncology patients. However, these antineoplastic treatments may also induce adverse cardiovascular effects, which may lead to acute or delayed onset of cardiac dysfunction ...
M. Morelli, Chiara Bongiovanni, Silvia Da Pra, Carmen Miano, Francesca Sacchi, M. Lauriola, G. D’Uva   +6 more
semanticscholar   +1 more source

Critical concepts, practice recommendations, and research perspectives of pixantrone therapy in non-Hodgkin lymphoma: a SIE, SIES, and GITMO consensus paper [PDF]

, 2016
Objectives: In this paper, we present a review of critical concepts and research perspectives and produce recommendations on the optimal use of pixantrone in non-Hodgkin lymphoma (NHL) by group discussion from an expert panel appointed by the Italian ...
Barosi, Giovanni, Corradini, Paolo, Martelli, Maurizio, Minotti, Giorgio, Oliva, Stefano, Spina, Michele, Tura, Sante, Zinzani, Pier Luigi   +7 more
core   +1 more source

Ageing alters the severity of Sunitinib-induced cardiotoxicity: Investigating the mitogen activated kinase kinase 7 pathway association [PDF]

, 2019
Anti-cancer drug Sunitinib is linked to adverse cardiovascular events, which have shown to involve mitogen activated kinase kinase 7 (MKK7) pathway. Sunitinib-induced cardiotoxicity in 3, 12 and 24 months old male Sprague-Dawley rats and MKK7 expression ...
Cooper, Samantha, Hussain, Afthab, Maddock, Helen, Mee, Christopher, Sandhu, Hardip   +4 more
core   +1 more source

Assessment of potential cardiotoxic side effects of mitoxantrone in patients with multiple sclerosis [PDF]

, 2005
Previous studies showed that mitoxantrone can reduce disability progression in patients with multiple sclerosis (MS). There is, however, concern that it may cause irreversible cardiomyopathy with reduced left ventricular (LV) ejection fraction (EF) and ...
Ariane Groβ, Athanasiou T, Avasarala JR, De Castro S, Dukart G, Edan G, Edan G, Foster BJ, Ghalie RG, Goffette S, Gonsette RE, Gonsette RE, Goodin DS, Hartung HP, Herman EH, Kappos L, Klaus Jahn, Koch CG, Kronik G, Kurtzke JF, Mather FJ, Mauch E, Michael Näbauer, Michael Strupp, Millefiorini E, Noseworthy JH, Posner LE, Reinhard Hohlfeld, Ruel M, Strotmann JM, Teichholz LE, Thomas Brandt, Vera Carina Zingler, Voltz R, Yudkin PL, Zephir H, Zingler VC   +36 more
core   +1 more source

Three tyrosine kinase inhibitors cause cardiotoxicity by inducing endoplasmic reticulum stress and inflammation in cardiomyocytes

BMC Medicine, 2023
Background Tyrosine kinase inhibitors (TKIs) are anti-cancer therapeutics often prescribed for long-term treatment. Many of these treatments cause cardiotoxicity with limited cure.
Huan Wang, Yiming Wang, Jiongyuan Li, Ziyi He, Sarah A. Boswell, Mirra Chung, Fuping You, Sen Han   +7 more
semanticscholar   +1 more source