Results 31 to 40 of about 64,429 (258)

Cardiotoxicity and cancer therapy [PDF]

, 2014
A fundamental concept of treatment is to do no harm. However, with cancer treatment this is not always possible. Chemotherapy is associated with cardiovascular (CV) complications.1,2 This risk is even greater in the elderly patients and patients with ...
Mikhailidis, DP, Vasiliadis, I, Kolovou, G   +2 more
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Machine learning prediction model combined with network toxicology analysis identifies potential cardiotoxic components and mechanisms among 741 pesticides

Environment International
The usage of pesticides in agriculture is substantial, but their application may pose potential risks of physical harm. Existing network toxicology methods for analysis and prediction lack the capability for structural early-warning of toxicity and are ...
Qi Yang, Hongsheng Liu, Guiyuan Pang, Yuemi Mo, Chenglin Zhou, Meiyu Huang, Chun Luo, Erwei Hao, Lili Fan   +8 more
doaj   +1 more source

Particulate matter induces arrhythmia-like cardiotoxicity in zebrafish embryos by altering the expression levels of cardiac development- and ion channel-related genes

Ecotoxicology and Environmental Safety, 2023
Air pollution is a risk factor that increases cardiovascular morbidity and mortality. In this study, we investigated the cardiotoxicity of particulate matter (PM) exposure using a zebrafish embryo model.
Kyu Hee Park, Yoon Ji Choi, Won Kee Min, Sun Hwa Lee, Jaeyoung Kim, Sang Hoon Jeong, Ju-Han Lee, Byung Min Choi, Suhyun Kim   +8 more
doaj   +1 more source

Microfluidic Droplet Plate Preserving Single Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Morphology and Function

Advanced Materials Technologies, EarlyView.
We introduce a novel method combining microfluidics, optogenetics, and human induced pluripotent stem cell (iPSC) technology to encapsulate single iPSC‐derived cardiomyocytes (iPSC‐CMs) in an optimal environment for functional characterization. This method enables direct genotype‐phenotype correlation for genetic studies and high‐throughput screening ...
Xiao‐Ting Wang, Rachel P. White, Yashasvi Tharani, Michael A. Finocchiaro, Leona M. Ripple, Maksymilian Prondzynski, Tania Konry, Vassilios J. Bezzerides   +7 more
wiley   +1 more source

A retrospective analysis of the association of obesity with anthracycline- and trastuzumab-induced cardiotoxicity in the treatment of breast cancer and lymphoma

Archives of Medical Science
Introduction Trastuzumab and anthracyclines are mainstays of chemotherapy in breast cancer and lymphoma patients but may cause significant cardiotoxicity, which may result in alterations to chemotherapy dose, schedule, or agent.
Mallorie L. Huff, Ranju Gupta, Rahul Gupta, Kelly C. Schadler, Shae Duka, Vienna Histon-Figliolini, Joshua Kalter, Amogh M. Joshi, Nadeem V. Ahmad, Wilbert S. Aronow, Deborah W. Sundlof   +10 more
doaj   +1 more source

A short-time model to study relevant indices of cardiotoxicity of doxorubicin in the rat [PDF]

, 2013
Aim: Short-time models (STM) to study the cardiotoxicity (acute or chronic) of doxorubicin in rats are of interest to assess protective interventions and pathways.
Hole, Lisa Drange, Larsen, Terje H., Limé, Fredrik, Schjøtt, Jan, Fossan, Kjell Ove   +4 more
core   +1 more source

Utility of myocardial work by echocardiography in the early diagnosis of cardiotoxicity [PDF]

Exploration of Cardiology
Aim: Evaluate the role of myocardial work by echocardiography and determine its utility as an early diagnosis of cardiotoxicity. Methods: Single-center included 180 patients over 18 years old undergoing chemotherapy, the definition of cardiotoxicity for ...
Denise Cortes-Pérez, Diana Romero-Zertuche, Gabriela Rodríguez-Guzmán, Itzel Calixto-Guízar, Carlos Martínez-Hernández   +4 more
doaj   +1 more source

Morphine enhances doxorubicin-induced cardiotoxicity in the rat [PDF]

, 2014
Interventions to reduce the cardiotoxicity of doxorubicin are clinically relevant. Pharmacological preconditioning mimicking ischemic preconditioning has been demonstrated with morphine and represents an acceptable clinical intervention.
Hole, Lisa Drange, Larsen, Terje H., Terje Hjalmar Larsen, Fredrik Limé, Limé, Fredrik, Jan Schjøtt, Schjøtt, Jan, Kjell Ove Fossan, Fossan, Kjell Ove, Lisa Drange Hole   +9 more
core   +1 more source

Anthracycline-induced cardiotoxicity: mechanisms, monitoring, and prevention [PDF]

, 2023
Anthracyclines are the most fundamental and important treatment of several cancers especially for lymphoma and breast cancer. However, their use is limited by a dose-dependent cardiotoxicity which may emerge early at the initiation of anthracycline ...
Yun Qiu, Yingmei Huang, Piao Jiang
core   +1 more source