Results 11 to 20 of about 119,936 (354)
Cardiotoxicity of Anthracyclines [PDF]
Frontiers in Cardiovascular Medicine, 2020 Cardiotoxicity is a feared side effect that may limit the clinical use of anthracyclines. It may indeed affect the quality of life and survival of patients with cancer, regardless of oncological prognosis. This paper provides an overview of anthracycline-
Daniela Cardinale +2 more
doaj +4 more sources
Nrf2: a dark horse in doxorubicin-induced cardiotoxicity
Cell Death Discovery, 2023 Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment. Unexpectedly, its cardiotoxic side effects have proven to be a formidable obstacle.
Xiaopeng Zhao +3 more
doaj +2 more sources
Understanding Anthracycline Cardiotoxicity From Mitochondrial Aspect
Frontiers in Pharmacology, 2022 Anthracyclines, such as doxorubicin, represent one group of chemotherapy drugs with the most cardiotoxicity. Despite that anthracyclines are capable of treating assorted solid tumors and hematological malignancies, the side effect of inducing cardiac ...
Junqi Huang +5 more
doaj +2 more sources
Frontiers in Cardiovascular Medicine, 2022 BackgroundImmune checkpoint inhibitors (ICIs) have achieved acknowledged progress in cancer therapy. However, ICI-associated cardiotoxicity as one of the most severe adverse events is potentially life-threatening, with limited real-world studies ...
Xue Chen +11 more
doaj +1 more source
International Journal on Biological Sciences, 2022 Cancer is a destructive disease that causes high levels of morbidity and mortality. Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use places survivors at risk for cardiotoxicity. Many studies have demonstrated that
C. Kong +7 more
semanticscholar +1 more source
Toll-like Receptor 4 Inflammatory Perspective on Doxorubicin-Induced Cardiotoxicity
Molecules, 2023 Doxorubicin (Dox) is one of the most frequently used chemotherapeutic drugs in a variety of cancers, but Dox-induced cardiotoxicity diminishes its therapeutic efficacy.
Natticha Sumneang +2 more
doaj +1 more source
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021 Doxorubicin (Dox) is a secondary metabolite of the mutated strain of Streptomyces peucetius var. Caesius and belongs to the anthracyclines family.
P. S. Rawat +4 more
semanticscholar +1 more source
Regulated cell death pathways in doxorubicin-induced cardiotoxicity
Cell Death and Disease, 2021 Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug.
E. Christidi, L. Brunham
semanticscholar +1 more source
Paracetamol cardiotoxicity [PDF]
Postgraduate Medical Journal, 1993 Summary A 29 year old man with a significant paracetamol overdose was found to have an abnormal electrocardiograph which, in the absence of hepatic encephalopathy, was considered due to a direct cardiotoxic effect of the drug. A functional coronary insufficiency resulting from inhibition of endothelium-derived relaxing factor secondary ...
A, Armour, S D, Slater
openaire +2 more sources
Ranolazine Attenuates Trastuzumab-Induced Heart Dysfunction by Modulating ROS Production [PDF]
, 2018 The ErbB2 blocker trastuzumab improves survival in oncologic patients, but can cause cardiotoxicity. The late Na+ current inhibitor ranolazine has been shown to counter experimental HF, including doxorubicin cardiotoxicity (a condition characterized by ...
Carlo G. Tocchetti +16 more
core +5 more sources