Results 21 to 30 of about 119,936 (354)
Journal of Translational Medicine, 2023 Background Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore alternative treatment molecules or drugs for mitigating DIC.
Panpan Tai +28 more
semanticscholar +1 more source
Anthracycline-induced cardiotoxicity - are we about to clear this hurdle?
European Journal of Cancer, 2023 Anthracyclines have contributed significantly to remarkable improvements in overall survival and are regarded as the most effective cytostatic drug for cancer treatment in various malignancies. However, anthracyclines are a significant cause of acute and
W. Dempke +5 more
semanticscholar +1 more source
Doxorubicin-induced cardiotoxicity and risk factors
International Journal of Cardiology: Heart & Vasculature, 2023 Doxorubicin (DOX) is an anthracycline antibiotic widely used as a chemotherapeutic agent to treat solid tumours and hematologic malignancies. Although useful in the treatment of cancers, the benefit of DOX is limited due to its cardiotoxic effect that is
Carl Belger +3 more
semanticscholar +1 more source
Cardiovascular complications in patients with cancer: focus on anthracycline-induced cardiotoxicity
Кардиоваскулярная терапия и профилактика, 2021 The article describes prevalence and risk factors of cardiovascular in patients with cancer. The problems of anthracycline-induced cardiotoxicity, the deleterious effects of doxorubicin on the heart, as well as the cardioprotective effects of beta ...
I. T. Murkamilov +5 more
doaj +1 more source
eJHaem, 2020 We investigated the incidence of cardiotoxicity, its risk factors, and the clinical course of cardiac function in patients with malignant lymphoma (ML) who received a cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) regimen.
Takafumi Nakayama +19 more
doaj +1 more source
Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α
Cell Death and Disease, 2022 Doxorubicin (DOX)-based chemotherapy is widely used to treat malignant tumors; however, the cardiotoxicity induced by DOX restricts its clinical usage. A therapeutic dose of DOX can activate ubiquitin-proteasome system. However, whether and how ubiquitin-
Yihui Shen +10 more
doaj +1 more source
Journal of Cardiovascular Magnetic Resonance, 2017 Background Regional variability of longitudinal strain (LS) has been previously described with echocardiography in patients with cardiac amyloidosis (CA), however, the reason for this variability is not completely evident.
Lynne K. Williams +7 more
doaj +1 more source
Journal of Clinical and Translational Science, 2021 IMPACT: Advanced cardiac magnetic resonance imaging techniques can help to protect cancer patients from cardiotoxicity from immunotherapy with a more sensitive assessment of cardiac function with strain imaging for detection of abnormal cardiac function ...
Jason Cuomo +8 more
doaj +1 more source
Annals of Oncology, 2010 Cancer treatment has improved extraordinarily in recent years. The development of targeted therapies has widened the cardiotoxic spectrum of antineoplastic drugs. Optimum management of cardiovascular disease before and during antineoplastic treatment is essential to reduce morbidity and mortality in cancer patients.
I, Brana, J, Tabernero
openaire +2 more sources
Decreased soluble guanylate cyclase contributes to cardiac dysfunction induced by chronic doxorubicin treatment in mice [PDF]
, 2017 Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity ...
Allen, Kaitlin +15 more
core +1 more source