Results 21 to 30 of about 46,179 (165)

Paclitaxel-induced Cardiotoxicity: Mechanisms, Molecular Insights, and Clinical Implications [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Paclitaxel is a well-known chemotherapeutic agent used to treat various cancers, including breast, lung, and pancreatic cancers. However, its effectiveness is limited by significant adverse effects, including neurotoxicity, nephrotoxicity, hepatotoxicity,
El-Nagar, Yasmine M., George, Mina Y., El Wakeel, Sara, Elsherbiny, Doaa A.   +3 more
doaj   +1 more source

Risk factors of osimertinib-related cardiotoxicity in non-small cell lung cancer

Frontiers in Oncology
ObjectiveTo investigate the risk factors associated with cardiotoxicity in patients with non-small cell lung cancer (NSCLC) treated with osimertinib.MethodsA total of 268 patients with NSCLC treated with osimertinib in our hospital from June 2019 to ...
Yunlong Wang, Xuan Deng, Qinggui Qiu, Mengchao Wan   +3 more
doaj   +1 more source

Risk Compounds, Preclinical Toxicity Evaluation, and Potential Mechanisms of Chinese Materia Medica–Induced Cardiotoxicity

Frontiers in Pharmacology, 2021
Chinese materia medica (CMM) has been applied for the prevention and treatment of diseases for thousands of years. However, arrhythmia, myocardial ischemia, heart failure, and other cardiac adverse reactions during CMM application were gradually reported.
Jie Zhou, Jie Zhou, Jie Zhou, Fu Peng, Xiaoyu Cao, Xiaoyu Cao, Xiaofang Xie, Xiaofang Xie, Dayi Chen, Lian Yang, Chaolong Rao, Cheng Peng, Cheng Peng, Xiaoqi Pan, Xiaoqi Pan   +14 more
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The cardiotoxicity of eosinophils [PDF]

Postgraduate Medical Journal, 1983
Summary Although an association between high blood eosinophil counts and endomyocardial disease has been known for nearly a hundred years, the reasons for this were not understood. Brockington, Luzzatto and Osunkoya (1970) suggested that eosinophil leucocytes, in susceptible persons, by some unknown mechanisms, cause endomyocardial ...
C J, Spry, P C, Tai, J, Davies
openaire   +2 more sources

Cardiotoxicity in patients with metastatic melanoma treated with BRAF/MEK inhibitors: a real-world analysis of incidence, risk factors, and reversibility

Acta Oncologica
Background: BRAF/MEK inhibitors (BRAFi/MEKi) improve outcome in patients with BRAF-mutated metastatic melanoma but are associated with cardiotoxicity, leading to a decline in left ventricular ejection fraction (LVEF).
Jonas K. Oddershede, Ida K. Meklenborg, Lars Bastholt, Louise M. Guldbrandt, Henrik Schmidt, Rasmus B. Friis   +5 more
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Machine learning prediction model combined with network toxicology analysis identifies potential cardiotoxic components and mechanisms among 741 pesticides

Environment International
The usage of pesticides in agriculture is substantial, but their application may pose potential risks of physical harm. Existing network toxicology methods for analysis and prediction lack the capability for structural early-warning of toxicity and are ...
Qi Yang, Hongsheng Liu, Guiyuan Pang, Yuemi Mo, Chenglin Zhou, Meiyu Huang, Chun Luo, Erwei Hao, Lili Fan   +8 more
doaj   +1 more source

A Comprehensive Review of Clinical Cardiotoxicity Incidence of FDA-Approved Small-Molecule Kinase Inhibitors

Frontiers in Pharmacology, 2020
Numerous protein kinases encoded in the genome have become attractive targets for the treatment of different types of cancer. As of January 2020, a total of 52 small-molecule kinase inhibitors (SMKIs) have been approved by the FDA.
Ying Jin, Zhifei Xu, Hao Yan, Qiaojun He, Xiaochun Yang, Peihua Luo   +5 more
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Clinical Manifestations, Monitoring, and Prognosis: A Review of Cardiotoxicity After Antitumor Strategy

Frontiers in Cardiovascular Medicine, 2022
The development of various antitumor drugs has significantly improved the survival of patients with cancer. Many first-line chemotherapy drugs are cytotoxic and the cardiotoxicity is one of the most significant effects that could leads to poor prognosis ...
Wei Huang, Rong Xu, Bin Zhou, Chao Lin, Yingkun Guo, Huayan Xu, Xia Guo   +6 more
doaj   +1 more source

Review of the clinical status of cardiotoxicity of HER-2 positive breast cancer targeted therapeutic drugs

Frontiers in Oncology
Breast cancer is a major health challenge for women worldwide, and human epidermal growth factor receptor 2 (HER-2)-positive breast cancers have a relatively high incidence and are highly aggressive.
Xiang Zhang, Yulian Yin, Qiuting Yu, Xinlin Chen, Yiqin Cheng   +4 more
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Particulate matter induces arrhythmia-like cardiotoxicity in zebrafish embryos by altering the expression levels of cardiac development- and ion channel-related genes

Ecotoxicology and Environmental Safety, 2023
Air pollution is a risk factor that increases cardiovascular morbidity and mortality. In this study, we investigated the cardiotoxicity of particulate matter (PM) exposure using a zebrafish embryo model.
Kyu Hee Park, Yoon Ji Choi, Won Kee Min, Sun Hwa Lee, Jaeyoung Kim, Sang Hoon Jeong, Ju-Han Lee, Byung Min Choi, Suhyun Kim   +8 more
doaj   +1 more source