Results 231 to 240 of about 3,242,366 (329)

Stage‐Dependent Prognostic Value of the Joint MASLD–NAFLD Fibrosis Score Phenotype Across the Cardiovascular–Kidney–Metabolic Syndrome Continuum: A Retrospective NHANES Cohort Analysis, 1999–2018

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The cardiovascular–kidney–metabolic (CKM) framework and metabolic dysfunction–associated steatotic liver disease (MASLD) describe a shared clinical continuum, but the prognostic value of joint fatty liver index (FLI)–NAFLD fibrosis score (NFS) phenotypes across CKM stages is uncertain.
Yi‐Fei Wang, Jian‐Li Zhang, Yun‐Fei Wang, Jun‐Peng Xiong, Rong‐Hui Yu, Ze‐Ping Hu   +5 more
wiley   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Editorial: Community series in: cardiovascular risks in cardiovascular-kidney-metabolic syndrome: mechanisms and therapies, volume II. [PDF]

Front Endocrinol (Lausanne)
Zhou R, Zhang B, Wang W, Piao J, Ma W.
europepmc   +1 more source

Multiomics Insights Into AL Amyloidosis

Medicine Bulletin, EarlyView.
ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor prognosis and high mortality rates.
Zixuan Zhang, Ziru Huang, Haoxiang Tang, Xianrun Pan, Rong Wang, Dingding Zhang, Jian Huang   +6 more
wiley   +1 more source

Sex differences in cardiovascular‑kidney‑metabolic syndrome: From pathogenesis to treatment response (Review). [PDF]

Int J Mol Med
Fan Y, Hu H, Cheng J.
europepmc   +1 more source

Vascular Aging and Cardiovascular-Kidney-Metabolic Syndrome

JACC: Advances
Yoshitake Fukuda, Kentaro Ejiri
openaire   +3 more sources

Harnessing Aggregation‐Induced Emission for Advanced Disease Diagnosis: Mechanisms, Strategies and Future Perspectives

Medicine Bulletin, EarlyView.
The figure was created in BioRender.com. ABSTRACT Accurate and early diagnosis remains a key challenge in modern disease management. Conventional diagnostic methods often suffer from limitations in sensitivity, spatial resolution, and practical usability.
Zizhuo Du, Li Song, Xingrui Chen, Jun Jing, Yingchen Wang, Yue Jiang, Jiahui Gao, Dan Li, Feiran Xie, Peihong Xiao, Ben Zhong Tang   +10 more
wiley   +1 more source

Targeting Inflammation in Obesity and the Cardiovascular-Kidney-Metabolic Syndrome Spectrum: A Narrative Review. [PDF]

Obes Facts
Noormandi A, Bugger H, Aziz F, Milicevic Z, von Lewinski D, Ludvik B, Parzer V, Zirlik A, Pieber TR, Dimai HP, Sourij H.   +10 more
europepmc   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source