Results 91 to 100 of about 4,308,682 (335)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Understanding employee resourcing in construction organizations [PDF]

, 2008
In recent years the literature on employee resourcing has consistently advocated the importance of adopting a holistic, strategic approach to employee deployment decision making rather than adopting a reactive needs-based approach.
Anderson S. D., Andrew R. J. Dainty, Ani Birgit Raiden, Armstrong M., Armstrong M., Belbin R. M., Boxall P., Boyatzis R. E., Bramham J., Corbridge M., Druker J., Glaser B. G., Guest D., Hillebrandt P. M., Iles P., Langford D., Loosemore M., Marchington M., Margerison C., Miles M. B., Patton M. Q., Pfeffer J., Pilbeam S., Purcell J., Richard H. Neale, Taylor S., Torrington D., Ulrich D., Walker D. H. T., Watson T., Wood S., Yin R. K.   +31 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Importance of family support in planning educational and professional careers by young adults from Generation Z [PDF]

Studia z Teorii Wychowania
The construction of educational and professional careers is the subject of research in many scientific studies. The research carried out is based on very diverse scientific concepts.
Katarzyna Jagielska
doaj   +1 more source

Changing Scottish education policy definitions of what it means to be a teacher: fit for a diverse system? [PDF]

, 2014
As countries seek to secure their economic future, education has become increasingly central to socioeconomic strategy in the United Kingdom and beyond.
Patrick, Fiona, Razzaq, Jamila
core  

Subordinating careers to market forces? A critical analysis of European career guidance policy [PDF]

, 2012
This study explores language regarding career and career development in European policy documents on career guidance in order to disclose underlying view(s) of these phenomena conveyed in the texts.
Bergmo-Prvulovic, Ingela
core   +1 more source

Group Career Construction Counseling: A Mixed-Methods Intervention Study With High School Students

Career Development Quarterly, 2019
This study investigated the value of group career construction counseling in a high school context. The author used purposive sampling to select participants who had sought career counseling.
J. Maree
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Mediated Bodies: The construction of a Wife, Mother, and the Female Body in Television Sitcoms: Roseanne [PDF]

, 2013
After first examining several theoretical concepts related to the construction of gender on television and the way in which women are characterized, this paper examines the television show Roseanne to explore the way it changed the representation of a ...
Ghanoui, Saniya Lee
core   +1 more source