Results 51 to 60 of about 3,763,257 (287)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Lessons construction can learn from other sectors [PDF]
, 2006 The construction industry is traditionally considered a white, maledominated industry. The UK construction industry is at its busiest for a decade and is suffering from skill shortages in both craft and manual trades, and at the professional level ...
Amaratunga, Dilanthi +2 more
core +2 more sources
South African Journal of Education, 2020 In this article I report on how conscious knowledge could be connected with subconscious advice through career construction counselling to resolve the career choice indecision of a postgraduate psychology student. The participant was purposively selected
Jacobus Gideon Maree
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Journal of Economy Culture and SocietyThe 21st century has witnessed rapid and profound transformations that have reshaped working life. These changes significantly impact Generation Z, which is regarded as the workforce of the future.
Başak Kıcır, Aşkın Keser
doaj +1 more source
Mid-career construction counselling to instill spiritual awareness and allay fear
South African Journal of Education, 2017 This article reports on the value of career construction counselling for a black man facing a career crossroads. The participant was purposefully selected from a number of people participating in a career construction counselling course who had sought ...
JG (Kobus) Maree
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Frontiers in PsychologyIntroductionIn today’s dynamic landscape, navigating career paths in the midst of economic, societal, and technological changes has become increasingly challenging.
Anna Parola +3 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Early career women in construction: career choice and barriers
IOP Conference Series: Materials Science and Engineering, 2019 Abstract Retaining female students through graduation and sending them out into the construction industry remain as challenges for greater women participation in the industry. This study examines the factors affecting early career women’s career choice in construction and barriers faced by them at this career stage.
Bee Lan Oo +2 more
openaire +1 more source