Results 61 to 70 of about 925,551 (292)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Occupation Profile: Architects, October 5, 2017 [PDF]

, 2017
Plan and design structures, such as private residences, office buildings, theaters, factories, and other structural property.

core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Career adaptability as an instructional scaffold for career education in South African schools

African Journal of Career Development
Background: South African learners need more career preparation, as it provides a sense of control in the current economic climate of high unemployment, as confirmed by the business sector.
Marlene Algra, Hermien Olivier
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Individualized career counseling outcome assessment: A case study using the personal questionnaire [PDF]

, 2019
Career counseling evolved to practices that attribute a central importance to context variables and meaning-making processes. Accordingly, there is a call for the assessment of client’s subjectivity and cultural specificity, considering the interface ...
Cardoso, Paulo, Sales, Célia
core   +1 more source

Early career women in construction: career choice and barriers

IOP Conference Series: Materials Science and Engineering, 2019
Abstract Retaining female students through graduation and sending them out into the construction industry remain as challenges for greater women participation in the industry. This study examines the factors affecting early career women’s career choice in construction and barriers faced by them at this career stage.
Bee Lan Oo, Xiyu Feng, Benson Teck-Heng Lim   +2 more
openaire   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Mark Savickas’ theory as an inspiration for professional counselling aimed at adults enhanced with the application of Diagnostic and Simulation Games Method

Rocznik Andragogiczny, 2016
In case of adult learners, the process of professional counselling, diagnosing of professional predispositions or providing support for learners in their professional career construction frequently requires the application of different methods and ...
Przemysław Ziółkowski
doaj   +1 more source