Results 91 to 100 of about 1,985,934 (292)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Assessing the medium-term effects of a community-based medical education program with homestay practice: a cohort study in Tamba, Japan

open access: yesAnnals of Medicine
Introduction This study intended to evaluate the medium-term effectiveness of a community-based medical education (CBME) program and to determine the program’s influence on the application rates of regional-quota students seeking to become residents in ...
Tsuneaki Kenzaka   +5 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Understanding the phases and objectives of the career development process in the context of successful career management [PDF]

open access: yesTrendovi u Poslovanju, 2020
The basis of a quality organization consists of reliable employees who are satisfied with their work, ready to learn and progress, and thus continuously bring profit and progress to themselves and the organization.
Ilić Đurđijana
doaj  

Career Development of College Students through Part-Time Work: The Role of Leader-Member Exchange and Taking Charge Behavior [PDF]

open access: yes
This study examines the potential benefit of college students' part-time work on their career development by focusing on leader-member exchange (LMX) and taking charge behavior in the workplace.
Tomoki Sekiguchi
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

A case study of South Africa: Strengthening pathways from education to the world of work

open access: yesAfrican Journal of Career Development
The European Union (EU)-supported Education for Employability (E4E) Technical Assistance project in South Africa aimed to enhance youth employability by aligning education, training and employment systems.
Christopher J. Beukes   +8 more
doaj   +1 more source

The Effect of Career Development Services on Student Career Maturity (a Study on University Student of Faculty of Adminstrative Science at Brawijaya University in Malang, East Java) [PDF]

open access: yes, 2017
This study aims to identify and explain the effect of career development services (orientation services, information services, placement and distribution services, guidance and individual counseling) simultaneously and partially on student career ...
Kawuryan, R. (Renita)   +2 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

An analysis of bank productivity in Indonesia: The impact of P2P lending and digital payments using the Malmquist Productivity Index

open access: yesJurnal Perspektif Pembiayaan dan Pembangunan Daerah
This study investigates the relationship between technological adoption and banking productivity, specifically focusing on Indonesian banks over five years.
Fajra Octrina   +3 more
doaj   +1 more source

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