Results 51 to 60 of about 21,446 (287)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

An investigation of at-risk students career aspirations [PDF]

, 2000
Plan BThe transition from adolescence to a forty hour a week, tax paying member of society can be for some, chaotic and overwhelming. According to Peterson, Long, & Billups, (1999, p.
Schmidt-King, Jennifer Anne
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Career Development of College Students through Part-Time Work: The Role of Leader-Member Exchange and Taking Charge Behavior [PDF]

This study examines the potential benefit of college students' part-time work on their career development by focusing on leader-member exchange (LMX) and taking charge behavior in the workplace.
Tomoki Sekiguchi
core  

Hope as a resource for career exploration: Examining incremental and cross-lagged effects

, 2015
Hope is believed to be beneficial for vocational pursuits, but the question of how and why hope is related to pivotal career development variables remains largely unaddressed.
Abessolo, Marc, Abessolo, M., Froidevaux, A., Hirschi, A., Hirschi, Andreas, Froidevaux, Ariane   +5 more
core   +1 more source

Transformation leadership with knowledge sharing and employee career growth: the role of self-efficacy and psychological capital

Frontiers in Psychology
Existing research lacks a systematic exploration of the relationships among transformational leadership, knowledge sharing, and employee career growth, as well as the mechanisms of self-efficacy and psychological capital in this context, especially the ...
Yun Bai
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Career development learning in higher education: how authentic work experiences and opportunities for career exploration canincrease self-efficacy and inform career identity

, 2015
A recent study suggests that enhancing career development is a key motivator for students entering university (Kandiko & Mawer, 2013). This article discusses the place of career development learning within the ‘employability’ agenda.
Benton, Paula
core  

Designing a measurement scale for student engagement motivation in higher education

Cakrawala Pendidikan: Jurnal Ilmiah Pendidikan
This research aims to present comprehensive literature on student engagement motivation (SEMo) from specific perspectives to develop a scale measuring its domain.
Quynh Hai Quynh, Hoai Thanh Nguyen
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source