Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1057-1069, April 2026.Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka +12 more
wiley +1 more source
Anti-aggregating effect of the naturally occurring dipeptide carnosine on aβ1-42 fibril formation.
PLoS ONE, 2013 Carnosine is an endogenous dipeptide abundant in the central nervous system, where by acting as intracellular pH buffering molecule, Zn/Cu ion chelator, antioxidant and anti-crosslinking agent, it exerts a well-recognized multi-protective homeostatic ...
Alessandra Aloisi +6 more
doaj +1 more source
OXIDATIVE CHANGES OF LIPIDS, PROTEINS AND ANTIOXIDANTS IN YOGURT DURING THE SHELF LIFE [PDF]
, 2017 Background: Oxidation processes in milk and yogurt during the shelf life can result in an alteration of protein and lipid constituents. Therefore, the antioxidant properties of yogurt in standard conditions of preservation were evaluated. Results: Total
Bellamio, Marco +7 more
core +1 more source
Additive effects of beta-alanine and sodium bicarbonate on high-intensity upper-body intermittent performance [PDF]
, 2013 We examined the isolated and combined effects of beta-alanine (BA) and sodium bicarbonate (SB) on high-intensity intermittent upper-body performance in judo and jiu-jitsu competitors. 37 athletes were assigned to one of four groups: (1) placebo (PL)+PL;
Artioli, GG +8 more
core +2 more sources
Effects of Carnosine on the Toxicity of Doxorubicin in Rabbits and Mice
Pteridines, 2003 The aim of this study was to establish the effect of naturally occurring antioxidant - carnosine - on the doxorubicin induced cardiotoxicity in a rabbit model.
Zieba Remigiusz +4 more
doaj +1 more source
Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling.
PLoS ONE, 2019 Glioblastoma is a high-grade glioma with poor prognosis even after surgery and standard therapy. Here, we asked whether carnosine (β-alanyl-L-histidine), a naturally occurring dipeptide, exert its anti-neoplastic effect on glioblastoma cells via PI3K/Akt/
Henry Oppermann +4 more
doaj +1 more source
His+ reversions Caused in Salmonella typhimurium by different types of ionizing radiation [PDF]
, 1988 The yield of his+ reversions in the Ames Salmonella tester strain TA2638 has been determined for 60Co γ rays, 140 kV X rays, 5.4 keV characteristic X rays, 2.2 MeV protons, 3.1 MeV α particles, and 18 MeV/U Fe ions.
Fitzek, M. +3 more
core +1 more source
The role of Volatile Anesthetics in Cardioprotection: a systematic review. [PDF]
, 2012 This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Applegate, Richard L +5 more
core +1 more source
DNA as an enzyme: The effect of imidazole derivatives as cofactors and metal ions as activators or inhibitors [PDF]
, 2003 Objective: a highly sensitive spectrofluorometric method using dichlorofluorescin (LDCF) was employed to study the rate of electron transfer reaction in presence of DNA and some imidazole derivatives. Results: in our experiments, DNA possessed a unique
Bathaie, zahra. +3 more
core
Systematic review and stratified meta-analysis of the efficacy of carnosine in animal models of ischemic stroke [PDF]
, 2016 Carnosine is a naturally occurring pleotropic dipeptide which influences multiple deleterious mechanisms that are activated during stroke. Numerous published studies have reported that carnosine has robust efficacy in ischemic stroke models. To further
Bahor, Z. +4 more
core +1 more source