Results 111 to 120 of about 15,119 (225)

Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli [PDF]

, 2018
Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination.
Achcar, Fiona, Barrett, Michael P., Goodyear, Carl S., Pountain, Andrew W., Rattigan, Kevin M., Regnault, Clement, Vincent, Isabel M.   +6 more
core   +3 more sources

Carnosine ameliorates postoperative cognitive dysfunction of aged rats by limiting astrocytes pyroptosis

Neurotherapeutics
Postoperative cognitive dysfunction (POCD) is a common postoperative complication in elderly patients, and neuroinflammation is a key hallmark. Recent studies suggest that the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome ...
Jiahong Shen, Jiawen Xu, Yuxin Wen, Zili Tang, Jiaqi Li, Jianliang Sun   +5 more
doaj   +1 more source

"Nutraceuticals" in relation to human skeletal muscle and exercise. [PDF]

, 2017
Skeletal muscles have a fundamental role in locomotion and whole body metabolism, with muscle mass and quality being linked to improved health and even lifespan.
Bethan E. Phillips, Bloch K, Colleen S. Deane, Daniel J. Wilkinson, Dempsey RL, Hirsh S, Huffman DM, Jouris KB, Kenneth Smith, Kraemer WJ, Newsholme P, Philip J. Atherton, Timothy Etheridge, Vukovich MD, Ziegenfuss T   +14 more
core   +2 more sources

Carnosine, carnosinase and kidney diseases

Postępy Higieny i Medycyny Doświadczalnej, 2012
 Carnosine (beta-alanyl-L-histidine) is an endogenously synthesized dipeptide which is present in different human tissues, including the kidney. Carnosine is hydrolyzed by the enzyme carnosinase. There are two carnosinase homologues: serum secreted carnosinase and non-specific cytosolic dipeptidase, encoded by the genes CNDP1 and CNDP2 respectively and
openaire   +2 more sources

The muscle metabolome differs between healthy and frail older adults [PDF]

, 2016
Populations around the world are aging rapidly. Age-related loss of physiological functions negatively affects quality of life. A major contributor to the frailty syndrome of aging is loss of skeletal muscle. In this study we assessed the skeletal muscle
Alves, Rodrigo D. A. M., Boekschoten, Mark V., de Groot, Lisette C.P.G.M., Fazelzadeh, Parastoo, Hangelbroek, Roland W. J., Muller, Michael, Smilde, Age K., Tieland, Michael, van Duynhoven, John P. M., van Loon, Luc J. C., Verdijk, Lex B., Vervoort, Jacques   +11 more
core   +3 more sources

Genome-wide association studies of anserine and carnosine contents in the breast meat of Korean native chickens

Poultry Science
: Histidine-containing dipeptides (HCDs), such as anserine and carnosine, are enormously beneficial to human health and contribute to the meat flavor in chickens.
Minjun Kim, Jean P. Munyaneza, Eunjin Cho, Aera Jang, Cheorun Jo, Ki-Chang Nam, Hyo Jun Choo, Jun Heon Lee   +7 more
doaj   +1 more source

CARNOSINE CONTENT AND MUSCLE OXIDATIVE STABILITY OF MALE AND FEMALE BROILER CHICKENS [PDF]

Poljoprivreda, 2011
Carnosine is a dipeptide with antioxidative effects in broiler muscles. Its anti-ageing effect has also been determined recently, which is especially important for human health and vitality preservation.
Gordana Kralik, Helga Medić, Nives Marušić, Zlata Kralik, Manuela Grčević   +4 more
doaj  

The determination of carnosine [PDF]

Biochemical Journal, 1928
W M, Clifford, V H, Mottram
openaire   +2 more sources

Deciphering angiotensin converting enzyme 2 (ACE2) inhibition dynamics: Carnosine's modulatory role in breast cancer proliferation – A clinical sciences perspective

Heliyon
Background: Angiotensin-converting enzyme 2 (ACE2) is a pivotal molecular nexus linking novel coronavirus disease to breast cancer. In-silico investigations have repurposed carnosine for both these conditions based on its potential ACE2 inhibitory ...
Sarah A. Melhem, Loai M. Saadah, Zeena S. Attallah, Iman A. Mansi, Saja H. Hamed, Wamidh H. Talib   +5 more
doaj   +1 more source

Carnosine, Constitution and Synthesis [PDF]

Biochemical Journal, 1918
G, Barger, F, Tutin
openaire   +2 more sources