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Carnosine and the processes of ageing
Maturitas, 2016The causes of ageing are usually regarded as multifactorial; thus effective regulation might be achieved by intervention at multiple sites. It has been suggested that the endogenous dipeptide carnosine, also available as a food supplement, possesses anti-ageing activity and may achieve its reported age-alleviating effects via a number of mechanisms ...
Alan R, Hipkiss +2 more
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Carnosine in Nucleated Erythrocytes
Nature, 1974IN the course of studies of the metabolism of intracerebrally administered L-U-14C-histidine in brains of mice and frogs (Rana pipiens), analyses were also performed on blood samples from the injected animals. The mice received 1.5×106 c.p.m. of the labelled histidine, and 1 h later samples of blood were taken by means of orbital puncture.
J N, Van Balgooy +2 more
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Experientia, 1981
Carnosine levels were determined in chick erythrocytes (2510 nmoles/g cells) and plasma from chick (27 nmoles/ml),rat and rabbit. Carnosine was also measured in rabbit reticulocyte-rich blood (105 nmoles/g cells), normal blood (18 nmoles/g cells) and in bone marrow.
J E, Seely, F D, Marshall
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Carnosine levels were determined in chick erythrocytes (2510 nmoles/g cells) and plasma from chick (27 nmoles/ml),rat and rabbit. Carnosine was also measured in rabbit reticulocyte-rich blood (105 nmoles/g cells), normal blood (18 nmoles/g cells) and in bone marrow.
J E, Seely, F D, Marshall
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Brain Research, 1979
The dipeptide, carnosine, its synthetic enzyme, carnosine synthetase, and its degradative enzyme, carnosinase, appear to be localized in the cytosol of mouse olfactory bulb and epithelium. Mouse olfactory bulbs and epithelium were prelabeled in vivo with [3H]carnosine following intranasal irrigation with [3H]beta-alanine.
J W, Harding, J V, O'Fallon
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The dipeptide, carnosine, its synthetic enzyme, carnosine synthetase, and its degradative enzyme, carnosinase, appear to be localized in the cytosol of mouse olfactory bulb and epithelium. Mouse olfactory bulbs and epithelium were prelabeled in vivo with [3H]carnosine following intranasal irrigation with [3H]beta-alanine.
J W, Harding, J V, O'Fallon
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Physiologic Properties of Anserine and Carnosine
American Journal of Physiology-Legacy Content, 1956Studies were made of physiologic responses to anserine and carnosine, isolated and synthetic, as measured by changes in diastolic, pulse and systolic blood pressure and peripheral blood flow in the cat and dog, and by oxytocic effects on smooth muscle of guinea pig and rabbit.
H M, HINES, D C, SUTFIN
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Carnosine reacts with a glycated protein
Free Radical Biology and Medicine, 2000Oxidation and glycation induce formation of carbonyl (CO) groups in proteins, a characteristic of cellular aging. The dipeptide carnosine (beta-alanyl-L-histidine) is often found in long-lived mammalian tissues at relatively high concentrations (up to 20 mM).
C, Brownson, A R, Hipkiss
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Carnosine and Carnosinase in Rat Tissue
Nature, 1957PAPER chromatography has been used for obtaining a qualitative picture of the distribution of carnosine and ‘carnosinase’ in the albino rat.
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Protective effect of carnosine in hyperthermia
Bulletin of Experimental Biology and Medicine, 1997Under the conditions of hyperthermia, carnosine (β-alanine-l-histidine) normalizes tissue contents of lipid peroxidation products, cytochrome P-450, serotonin, and histamine in rats and increases their survival after extreme hyperthermia.
L I, Deev +5 more
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Carnosine, carnitine, and Vladimir Gulevich
Journal of Chemical Education, 1974Vladimir Gulevich was a distinguished biochemist who was responsible for the discovery of several biologically important bases and who inspired some extremely capable students and associated to con...
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