Results 21 to 30 of about 39,628 (288)

Engineering an AB5 Protein Carrier [PDF]

Scientific Reports, 2018
AbstractThe promise of biologic therapeutics is hindered by the challenge to deliver their activity to biochemically relevant sites within diseased cells. The favourable application of the natural protein carriers of the AB5 toxin family to this challenge has been restricted owing to still unresolved requirements for assembling non-native cargo into ...
Birte Höcker, Birte Höcker, Bruce R. Lichtenstein   +2 more
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Lipid carrier proteins and ethanol

Journal of Biomedical Science, 2001
Ethanol has a pronounced effect on lipid homeostasis. It is our overall hypothesis that certain lipid carrier proteins are targets of acute and chronic ethanol exposure and that perturbation of these proteins induces lipid dysfunction leading to cellular pathophysiology. These proteins include both intracellular proteins and lipoproteins.
Nicolai A. Avdulov, Nicolai A. Avdulov, W. Gibson Wood, W. Gibson Wood, Svetlana V. Chochina, Svetlana V. Chochina, Urule Igbavboa, Urule Igbavboa   +7 more
openaire   +3 more sources

Trapping of the Enoyl-Acyl Carrier Protein Reductase–Acyl Carrier Protein Interaction [PDF]

Journal of the American Chemical Society, 2016
An ideal target for metabolic engineering, fatty acid biosynthesis remains poorly understood on a molecular level. These carrier protein-dependent pathways require fundamental protein-protein interactions to guide reactivity and processivity, and their control has become one of the major hurdles in successfully adapting these biological machines.
Tallorin, Lorillee, Finzel, Kara, Nguyen, Quynh G, Beld, Joris, La Clair, James J, Burkart, Michael D   +5 more
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Expression and function of Met-tRNAiMet carrier proteins in acute myeloid leukemia [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate the expression of Met-tRNAiMetcarrier proteins eIF2A, eIF2D and MCTS1 in normal hematopoietic stem cells (HSCs) and acute myeloid leukemia (AML) cells, and to study the effect of carrier proteins on the functions of AML cell ...
SU Peng-zhong, HE Jia-huan, YU Shan, WANG Xiao-shuang, YU Jia
doaj  

Counterion-release entropy governs the inhibition of serum proteins by polyelectrolyte drugs [PDF]

Biomacromolecules, 2018, 19 (2), pp 409-416, 2017
Dendritic polyelectrolytes constitute high potential drugs and carrier systems for biomedical purposes, still their biomolecular interaction modes, in particular those determining the binding affinity to proteins, have not been rationalized. We study the interaction of the drug candidate dendritic polyglycerol sulfate (dPGS) with serum proteins using ...
arxiv   +1 more source

A review on protein based nanocarriers for polyphenols: interaction and stabilization mechanisms

Food Innovation and Advances, 2023
Protein has been used as the carrier for protecting and targeting polyphenols and increasing their shelf-life. Interactions of a protein molecule with polyphenols are important, which change functions and physiochemical properties of the complex and ...
Yun Xiao, Talha Ahmad, Tarun Belwal, Rana Muhammad Aadil, Muhammad Siddique, Limin Pang, Yanqun Xu   +6 more
doaj   +1 more source

Insights on the Quest for the Structure–Function Relationship of the Mitochondrial Pyruvate Carrier

Biology, 2020
The molecular identity of the mitochondrial pyruvate carrier (MPC) was presented in 2012, forty years after the active transport of cytosolic pyruvate into the mitochondrial matrix was first demonstrated.
José Edwin Neciosup Quesñay, Naomi L. Pollock, Raghavendra Sashi Krishna Nagampalli, Sarah C. Lee, Vijayakumar Balakrishnan, Sandra Martha Gomes Dias, Isabel Moraes, Tim R. Dafforn, Andre Luis Berteli Ambrosio   +8 more
doaj   +1 more source

Presentation matters: Impact of association of amphiphilic LPS with serum carrier proteins on innate immune signaling. [PDF]

PLoS ONE, 2018
Recognition of Pathogen-associated Molecular Patterns (PAMPs) by Toll-like receptors is central to innate immunity. Many bacterial PAMPs such as lipopolysaccharide (LPS) and lipoteichoic acid have amphiphilic properties. The hydrophobicity of amphiphilic
Loreen R Stromberg, Heather M Mendez, Jessica Z Kubicek-Sutherland, Steven W Graves, Nicolas W Hengartner, Harshini Mukundan   +5 more
doaj   +1 more source

DNA Scaffold Carrier Assisted Protein Translocation Through Solid-State Nanopore [PDF]

arXiv, 2022
The detection of biomolecules at the single molecular level have important applications in the fields of biosensing and biomedical diagnosis. Solid state nanopore (SS-nanopore) is an effective tool to perform the single molecular detection, due to its unique properties of label-free and less sample consumption. The current SS-nanopore translocations of
arxiv  

Transport proteins (carriers) of mitochondria [PDF]

IUBMB Life, 2008
AbstractMitochondria are subcellular structures essential to the aerobic eukaryotic cell. Their role extends much beyond their basic reactions of oxidative phosphorylation. It encompasses the steps critical for cellular metabolic pathways, for apoptosis, and for other processes such as antiviral signaling.
openaire   +3 more sources