Results 51 to 60 of about 312,617 (308)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Epididymosomes: transfer of fertility-modulating proteins to the sperm surface
Asian Journal of Andrology, 2015 A variety of glycosylphosphatidylinositol (GPI)-linked proteins are acquired on spermatozoa from epididymal luminal fluids (ELF) during sperm maturation.
Patricia A Martin-DeLeon
doaj +1 more source
Diseases Caused by Mutations in Mitochondrial Carrier Genes SLC25: A Review
Biomolecules, 2020 In the 1980s, after the mitochondrial DNA (mtDNA) had been sequenced, several diseases resulting from mtDNA mutations emerged. Later, numerous disorders caused by mutations in the nuclear genes encoding mitochondrial proteins were found. A group of these
Ferdinando Palmieri +2 more
doaj +1 more source
Journal of Biological Chemistry, 1973 Abstract A number of analogues of Escherichia coli apo-acyl carrier protein (apo-ACP) have been synthesized by the solid phase method. A standard isolation procedure was used for all analogues. This involved cleavage from the solid support and deprotection by treatment of the peptide-resin with hydrogen bromide and trifluoroacetic acid. The product was
Garland R. Marshall +2 more
openaire +3 more sources
Journal of Lipid Research, 1999 The transport of HDL cholesteryl esters (CE) from plasma to the liver involves a direct uptake pathway, mediated by hepatic scavenger receptor B-I (SR-BI), and an indirect pathway, involving the exchange of HDL CE for triglycerides (TG) of TG-rich ...
Xavier Collet +8 more
doaj
Assembly and Transfer of Iron–Sulfur Clusters in the Plastid
Frontiers in Plant Science, 2018 Iron-Sulfur (Fe-S) clusters and proteins are essential to many growth and developmental processes. In plants, they exist in the plastids, mitochondria, cytosol, and nucleus.
Yan Lu
doaj +1 more source
FEBS Letters, EarlyView.In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi +5 more
wiley +1 more source
The iron-sulfur cluster assembly machineries in plants: current knowledge and open questions
Frontiers in Plant Science, 2013 Many metabolic pathways and cellular processes occurring in most sub-cellular compartments depend on the functioning of iron-sulfur (Fe-S) proteins, whose cofactors are assembled through dedicated protein machineries.
Jérémy eCouturier +4 more
doaj +1 more source
Membrane‐Based Olefin/Paraffin Separations
Advanced Science, 2020 Efficient olefin/paraffin separation is a grand challenge because of their similar molecular sizes and physical properties, and is also a priority in the modern chemical industry.
Yanxiong Ren +9 more
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source