Results 191 to 200 of about 1,704 (241)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Migration and separation among Latinx asylum seekers: Experiences and relations with anxiety and depression. [PDF]

open access: yesJ Affect Disord Rep
Venta A   +6 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

[Why be a rural family doctor?] [PDF]

open access: yesAten Primaria
García Fernández JJ.
europepmc   +1 more source

Temporal Trends and Characteristics of Community-Based HIV Testing: First Community-Based Testing Program Results of Men Who Had Sex with Men and Female Sex Workers in Haiti, 2015-2018. [PDF]

open access: yesAm J Trop Med Hyg
Alain T   +10 more
europepmc   +1 more source

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