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New frontiers for cartilage repair, joint preservation and prevention [PDF]

Journal of Cartilage & Joint Preservation, 2022
Damaged cartilage is seen with increasing frequency after joint trauma, alone or in combination with other joint injuries. A poor healing of injured cartilage leads to great disability and pain and could by time develop into osteoarthritis (OA).
Mats Brittberg
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Differential regulation of the water channel protein aquaporins in chondrocytes of human knee articular cartilage by aging

Scientific Reports, 2021
Knee cartilage is in an aqueous environment filled with synovial fluid consisting of water, various nutrients, and ions to maintain chondrocyte homeostasis.
Bong Soo Kyung, Koo Whang Jung, Woo Jin Yeo, Hye Kyung Seo, Yong-Soo Lee, Dong Won Suh   +5 more
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Vitamin D Receptor Genetic Variations May Associate with the Risk of Developing Late Fracture-Related Infection in the Chinese Han Population

Journal of Immunology Research, 2022
Variations in the vitamin D receptor (VDR) gene are related to several inflammatory disorders. However, the potential links between such alternations and the risk of developing late fracture-related infection (FRI) remain unclear. This study investigated
Xing-qi Zhao, Kun Chen, Hao-yang Wan, Si-ying He, Han-jun Qin, Bin Yu, Nan Jiang   +6 more
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Repairing a critical cranial defect using WISP1-pretreated chondrocyte scaffolds

Journal of Tissue Engineering, 2023
In cranial flat bone fractures, spontaneous bone repair will occur only when the fracture ends are in close contact. However, in cases wherein bone discontinuity is extensive, surgical interventions are often required.
Idan Carmon, Shira Kalmus, Anna Zobrab, Michael Alterman, Raphaelle Emram, May Gussarsky, Leonid Kandel, Eli Reich, Nardi Casap, Mona Dvir-Ginzberg   +9 more
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Periosteum-covered ACI (ACI-P) versus collagen membrane ACI (ACI-C): A single-surgeon, large cohort analysis of clinical outcomes and graft survivorship

Journal of Cartilage & Joint Preservation, 2021
Introduction: Autologous chondrocyte implantation (ACI) has undergone several technical modifications. Objectives: To compare clinical outcomes and graft survivorship between ''first-generation'' periosteum-covered ACI (ACI-P) and ''second-generation ...
Liana Leja, MS, Tom Minas, MD, MS
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The Role of Senescence-Associated Secretory Phenotype in Bone Loss

Frontiers in Cell and Developmental Biology, 2022
As the population of most nations have a large proportion of older individuals, there is an increase in the prevalence of osteoporosis. Consequently, scientists have focused their attention on the pathogenic mechanisms of osteoporosis.
Runjiu Zhu, Runjiu Zhu, Haoyang Wan, Haoyang Wan, Hong Yang, Mingrui Song, Mingrui Song, Yu Chai, Yu Chai, Bin Yu, Bin Yu   +10 more
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Matrix-Associated Chondroplasty: A Novel Platelet-Rich Plasma and Concentrated Nucleated Bone Marrow Cell–Enhanced Cartilage Restoration Technique

Arthroscopy Techniques, 2014
Bone marrow stimulation techniques such as microfracture for the treatment of articular cartilage defects so far solely reproduce mechanically inferior fibrous cartilage tissue, which might result in unsatisfactory clinical results at midterm.
Matthias R. Steinwachs, M.D., Bernhard Waibl, M.D., Stephanie Wopperer, M.D., Marcus Mumme, M.D.   +3 more
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Inhibition of NADPH Oxidases Prevents the Development of Osteoarthritis

Antioxidants, 2022
Increased oxidative stress in osteoarthritis (OA) cartilage mediates catabolic signal transduction leading to extracellular matrix degradation and chondrocyte apoptosis.
Jin Han, Donghwi Park, Ji Young Park, Seungwoo Han   +3 more
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Arthroscopic Treatment of Cartilage Lesions With Microfracture and BST-CarGel

Arthroscopy Techniques, 2014
Bone marrow stimulation techniques for the treatment of articular cartilage defects such as microfracture so far have solely reproduced mechanically inferior fibrous cartilage tissue, which might result in unsatisfactory clinical results at midterm ...
Matthias R. Steinwachs, M.D., Bernhard Waibl, M.D., Marcus Mumme, M.D.   +2 more
doaj   +1 more source

Cartilage Restoration Using Dehydrated Allogeneic Cartilage, Platelet-Rich Plasma, and Autologous Cartilage Mixture Sealed With Activated Autologous Serum

Arthroscopy Techniques, 2020
Articular cartilage injury is a common source of knee pain and dysfunction. Patients in whom conservative treatment fails may benefit from surgical intervention to restore function and alleviate pain.
Tracy M. Tauro, B.S., B.A., Abbott Gifford, Eric D. Haunschild, B.S., Ron Gilat, M.D., Michael C. Fu, M.D., Brian J. Cole, M.D., M.B.A.   +5 more
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