Results 121 to 130 of about 151,261 (309)

Reaction-Diffusion-Delay Model for EPO/TNF-$α$? Interaction in Articular Cartilage Lesion Abatement [PDF]

arXiv, 2011
Injuries to articular cartilage result in the development of lesions that form on the surface of the cartilage. Such lesions are associated with articular cartilage degeneration and osteoarthritis. The typical injury response often causes collateral damage, primarily an effect of inflammation, which results in the spread of lesions beyond the region ...
arxiv  

circNR3C2 promotes chondrogenic differentiation and cartilage repair of human adipose‐derived stem cells via the hsa‐miR‐647/SOX9 pathway

Animal Models and Experimental Medicine, EarlyView.
The hypothesis diagram illustrates the function and mechanism of circNR3C2: circNR3C2 overexpression can up‐regulate COL2, Aggrecan and SOX9 expression, and regulate chondrogenic differentiation of hADSCs by targeting hsa‐miR‐647. Abstract Background Human adipose‐derived stem cells (hADSCs) are seed cells with application prospects in cartilage repair.
Dabiao Hou, Huajun Wang, Hao Guo, Dongbin Luo, Xiaofei Zheng, Simin Luo   +5 more
wiley   +1 more source

Investigation of high frequency transducers and coded signals suitable for cartilage volume imaging [PDF]

arXiv, 2019
Cartilage degeneration in joints causing pain and various types of knee problems is a serious problem-affecting people in all ages. Degenerated articular cartilage is also known as a central hallmark of osteoarthritis, which is a complex musculoskeletal disorder involving numerous contributory genetic, constitutional and biomechanical factors.
arxiv  

Time‐ and dose‐related pathological changes in knee osteoarthritis rat model induced by monosodium iodoacetate

Animal Models and Experimental Medicine, EarlyView.
Time‐ and dose‐related pathological changes of knee osteoarthritis rat model induced by monosodium iodoacetate. Abstract Knee osteoarthritis (KOA) is a chronic degenerative disease. Monosodium iodoacetate (MIA) induction is the most commonly used therapeutic effect evaluation and mechanism of action research model; we observed a lack of standardization
Wei Pu, Qi Liu, Shuyan Xue, Siyuan Li, Nan Nan, Yang Liu, Huiqin Hao   +6 more
wiley   +1 more source

Engineering gene-activated bioprinted scaffolds for enhancing articular cartilage repair

Materials Today Bio
Untreated articular cartilage injuries often result in severe chronic pain and dyskinesia. Current repair strategies have limitations in effectively promoting articular cartilage repair, underscoring the need for innovative therapeutic approaches. A gene-
Min Wang, Jiachen Wang, Xin Xu, Erliang Li, Peng Xu   +4 more
doaj  

O-alg-THAM/gel hydrogels functionalized with engineered microspheres based on mesenchymal stem cell secretion recruit endogenous stem cells for cartilage repair

Bioactive Materials, 2023
Lacking self-repair abilities, injuries to articular cartilage can lead to cartilage degeneration and ultimately result in osteoarthritis. Tissue engineering based on functional bioactive scaffolds are emerging as promising approaches for articular ...
Yucong Li, Linlong Li, Ming Wang, Boguang Yang, Baozhen Huang, Shanshan Bai, Xiaoting Zhang, Nan Hou, Haixing Wang, Zhengmeng Yang, Chong Tang, Ye Li, Wayne Yuk-Wai Lee, Lu Feng, Micky D. Tortorella, Gang Li   +15 more
doaj  

Bony island within the articular cartilage of the knee in a child: a rare condition for early osteoarthritis

Orthopedic Reviews, 2011
Articular cartilage is a specific type of connective tissue composed of hydrated proteoglycans within a matrix of collagen fibrils. In the elderly population, it shows degenerative changes that may results in osteoarthritis.
Taku Hatta, Takehiko Sugita, Toshimi Aizawa, Masahiro Ohnuma, Atsushi Takahashi, Eiji Itoi   +5 more
doaj   +1 more source

A novel computational modelling to describe the anisotropic, remodelling and reorientation behaviour of collagen fibrres in articular cartilage [PDF]

arXiv, 2016
In articular cartilage the orientation of collagen fibres is not uniform, varying mostly with the depth on the tissue. Besides, the biomechanical response of each layer of the articular cartilage differs from the neighbouring ones, evolving through thickness as a function of the distribution, density and orientation of the collagen fibres.
arxiv  

Functional Synovium‐Based 3D Models in the Context of Human Disease and Inflammation

Advanced NanoBiomed Research, EarlyView.
The synovium is key to joint function but is often affected by diseases like rheumatoid arthritis. Finding better treatments is challenging because current lab models do not fully mimic real tissues. New 3D technologies, like bioprinting, offer better methods to study these diseases, improve drug testing, and develop personalized treatments, bringing ...
Amelia Heslington, Catharien M. U. Hilkens, Ana Marina Ferreira, Priscila Melo   +3 more
wiley   +1 more source

Who was the real sabertooth predator: Thylacosmilus or Thylacoleo?

The Anatomical Record, EarlyView.
Abstract Sabertoothed mammalian predators, all now extinct, were almost exclusively feloid carnivorans (Eutheria, Placentalia): here a couple of extinct metatherian predators are considered in comparison with the placental sabertooths. Thylacosmilus (the “marsupial sabertooth”) and Thylacoleo (the “marsupial lion”) were both relatively large (puma ...
Christine M. Janis
wiley   +1 more source