Results 21 to 30 of about 81,558 (199)

Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGFβ, and Wnt signaling in articular cartilage formation and osteoarthritis

Bone Research, 2022
Runt-related transcription factor 1 (Runx1) plays a key role in cartilage formation, but its function in articular cartilage formation is unclear. We generated non-inducible and inducible Runx1-deficient mice (Runx1 f/f Col2α1-Cre and Runx1 f/f Col2α1 ...
Yan Zhang, Tao Zuo, Abigail McVicar, Hui-Lin Yang, Yi-Ping Li, Wei Chen   +5 more
doaj   +1 more source

Morphological and mechanical alterations in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs

Frontiers in Bioengineering and Biotechnology, 2023
Objectives: This study aimed to investigate the morphological and mechanical changes in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs.Materials and methods: Hip joints of guinea pigs were investigated at 1,
Jiazi Gao, Pengling Ren, He Gong
doaj   +1 more source

Key roles of the superficial zone in articular cartilage physiology, pathology, and regeneration

Chinese Medical Journal
. The superficial zone (SFZ) of articular cartilage is an important interface that isolates deeper zones from the microenvironment of the articular cavity and is directly exposed to various biological and mechanical stimuli. The SFZ is not only a crucial
Li Guo, Pengcui Li, Xueqin Rong, Xiaochun Wei, Xiangxiang Pan   +4 more
doaj   +1 more source

Research progress of self-assembling peptide hydrogels in repairing cartilage defects

Frontiers in Materials, 2022
Due to the lack of blood vessels, nerves and lymphatic vessels, the capacity of articular cartilage to heal is extremely limited. Once damaged, it is urgent for articular cartilage to repair the injury.
Renyi Wang, Renyi Wang, Yuhao Wang, Yuhao Wang, Han Yang, Chengzhi Zhao, Chengzhi Zhao, Jian Pan, Jian Pan   +8 more
doaj   +1 more source

Preferences for post‐traumatic osteoarthritis prevention strategies in individuals with anterior cruciate ligament injury

Arthritis Care &Research, Accepted Article.
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source

Engineering gene-activated bioprinted scaffolds for enhancing articular cartilage repair

Materials Today Bio
Untreated articular cartilage injuries often result in severe chronic pain and dyskinesia. Current repair strategies have limitations in effectively promoting articular cartilage repair, underscoring the need for innovative therapeutic approaches. A gene-
Min Wang, Jiachen Wang, Xin Xu, Erliang Li, Peng Xu   +4 more
doaj   +1 more source

Intra-Articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics.

PLoS ONE, 2015
Arthritic diseases, such as osteoarthritis and rheumatoid arthritis, inflict an enormous health care burden on society. Osteoarthritis, a degenerative joint disease with high prevalence among older people, and rheumatoid arthritis, an autoimmune ...
Venkatachalam Natarajan, Balaraman Madhan, Moti L Tiku   +2 more
doaj   +1 more source

Effects of low tangential permeability in the superficial layer on the frictional property of articular cartilage

Biosurface and Biotribology, 2015
The biphasic characteristics of articular cartilage are known to play important roles in cartilage lubrication. However, it is still difficult to biotribologically explain the extremely low friction coefficient observed in articular cartilage.
H. Fujie, K. Imade
doaj   +1 more source

Gene expression profiling reveals similarities between the spatial architectures of postnatal articular and growth plate cartilage. [PDF]

PLoS ONE, 2014
Articular and growth plate cartilage are discrete tissues but arise from a common cartilaginous condensation and have comparable spatial architectures consisting of distinct layers of chondrocytes.
Michael Chau, Julian C Lui, Ellie B M Landman, Stephan-Stanislaw Späth, Andrea Vortkamp, Jeffrey Baron, Ola Nilsson   +6 more
doaj   +1 more source

Diffusion‐Weighted Imaging for the Evaluation of the Sacroiliac Joint in Pediatric Patients

Arthritis Care &Research, EarlyView.
Objective Maturational signal in the sacroiliac joint (SIJ) of skeletally immature youth is often misinterpreted as inflammation. Diagnostic tools that improve specificity are greatly needed. Apparent diffusion coefficient (ADC) values from diffusion‐weighted imaging (DWI), when used with standard imaging, may enhance diagnostic accuracy.
Michael L. Francavilla, Timothy G. Brandon, Dmitry Khrichenko, Rui Xiao, Nancy A. Chauvin, Asef Khwaja, Pamela F. Weiss   +6 more
wiley   +1 more source