Scientific Reports, 2021 Articular cartilage is built by chondrocytes which become less active with age. This declining function of the chondrocytes, together with the avascular nature of the cartilage, impedes the spontaneous healing of chondral injuries.
Alexandre Dufour +10 more
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Direct Visualisation of the Depth-Dependent Mechanical Properties of Full-Thickness Articular Cartilage. [PDF]
, 2012 The structural anisotropy of articular cartilage controls its deformation response. As proteoglycans and collagen vary with depth, simple uniaxial compression results in inhomogeneous deformation with distinct depth-dependent mechanical properties ...
Szarko, M, Xia, Y
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Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9 [PDF]
, 2007 Objective. Human osteoarthritis (OA) is characterized by a pathologic shift in articular cartilage homeostasis toward the progressive loss of extracellular matrix (ECM).
Cucchiarini, Magali +5 more
core +2 more sources
Physiological incongruity of the humero-ulnar joint [PDF]
, 1993 Investigations into the distribution of subchondral bone density in the human elbow have suggested that the geometry of the trochlear notch deviates from a perfect fit with the trochlea, and that the load is transmitted ventrally and dorsally rather than
Eckstein, Felix +5 more
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Regulation of growth plate and articular chondrocyte differentiation : implications for longitudinal bone growth and articular cartilage formation [PDF]
, 2014 Overall height and body proportions in humans are determined primarily by bone growth. Linear bone growth occurs at the growth plate, a thin layer of cartilage at the ends of long bones between the epiphysis and metaphysis.
Chau, Michael
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24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats [PDF]
, 2016 Osteoarthritis (OA) in humans is associated with low circulating 25-hydroxyvitamin D3 [25 (OH)D3]. In vitamin D replete rats, radiolabeled 24R,25-dihydroxyvitamin D3 [24R,25 (OH)2D3] accumulates in articular cartilage following injection of [3 H]-25(OH ...
Boyan, Barbara D. +6 more
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Application of an acoustofluidic perfusion bioreactor for cartilage tissue engineering [PDF]
, 2014 Cartilage grafts generated using conventional static tissue engineering strategies are characterised by low cell viability, suboptimal hyaline cartilage formation and, critically, inferior mechanical competency, which limit their application for ...
Li, Siwei +7 more
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Gels, 2021 Joint diseases that mainly lead to articular cartilage injury with prolonged severe pain as well as dysfunction have remained unexplained for many years.
Xu Han +4 more
doaj +1 more source
Scientific Reports, 2017 The catabolism of hyaluronan in articular cartilage remains unclear. The aims of this study were to investigate the effects of hyaluronidase 2 (Hyal2) knockdown in articular cartilage on the development of osteoarthritis (OA) using genetic manipulated ...
Yoshitoshi Higuchi +10 more
doaj +1 more source
A review of the differences between normal and osteoarthritis articular cartilage in human knee and ankle joints [PDF]
, 2009 Background: Osteoarthritis (OA) is the most common joint disease yet its pathophysiology is still poorly understood. It is more prevalent in some lower limb joints than others; in particular the knee is more commonly affected than the ankle.
Beeson, Paul +2 more
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