Journal of Orthopaedic Surgery and Research, 2008 Introduction The collagen structure in the superficial zone of articular cartilage is critical to the tissue's durability. Early osteoarthritis is often characterized with fissures on the articular surface.
Zheng Ming H, Kirk Thomas B, Wu Jian P
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Regulation of growth plate and articular chondrocyte differentiation : implications for longitudinal bone growth and articular cartilage formation [PDF]
, 2014 Overall height and body proportions in humans are determined primarily by bone growth. Linear bone growth occurs at the growth plate, a thin layer of cartilage at the ends of long bones between the epiphysis and metaphysis.
Chau, Michael
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Scientific Reports, 2021 Articular cartilage is built by chondrocytes which become less active with age. This declining function of the chondrocytes, together with the avascular nature of the cartilage, impedes the spontaneous healing of chondral injuries.
Alexandre Dufour +10 more
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Physiological incongruity of the humero-ulnar joint [PDF]
, 1993 Investigations into the distribution of subchondral bone density in the human elbow have suggested that the geometry of the trochlear notch deviates from a perfect fit with the trochlea, and that the load is transmitted ventrally and dorsally rather than
Eckstein, Felix +5 more
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Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9 [PDF]
, 2007 Objective. Human osteoarthritis (OA) is characterized by a pathologic shift in articular cartilage homeostasis toward the progressive loss of extracellular matrix (ECM).
Cucchiarini, Magali +5 more
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24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats [PDF]
, 2016 Osteoarthritis (OA) in humans is associated with low circulating 25-hydroxyvitamin D3 [25 (OH)D3]. In vitamin D replete rats, radiolabeled 24R,25-dihydroxyvitamin D3 [24R,25 (OH)2D3] accumulates in articular cartilage following injection of [3 H]-25(OH ...
Boyan, Barbara D. +6 more
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Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures [PDF]
, 2013 The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years cartilage tissue engineering has shown great promise.
Blitterswijk, C.A. van +4 more
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Application of an acoustofluidic perfusion bioreactor for cartilage tissue engineering [PDF]
, 2014 Cartilage grafts generated using conventional static tissue engineering strategies are characterised by low cell viability, suboptimal hyaline cartilage formation and, critically, inferior mechanical competency, which limit their application for ...
Li, Siwei +7 more
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Differential gene expression associated with postnatal equine articular cartilage maturation
BMC Musculoskeletal Disorders, 2008 Background Articular cartilage undergoes an important maturation process from neonate to adult that is reflected by alterations in matrix protein organization and increased heterogeneity of chondrocyte morphology.
Stromberg Arnold J +3 more
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Arthroscopy, Sports Medicine, and Rehabilitation, 2021 Purpose: To establish normative values for articular cartilage thickness in pediatric and adolescent knees using magnetic resonance imaging (MRI) and investigate for any associations with age and skeletal maturity.
Sreetha Sidharthan, M.D. +6 more
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