Results 61 to 70 of about 278,892 (274)
Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.Osteoporosis induced by Glucocorticoids (GCs) is a common complication of long‐term GC use in patients with inflammatory and autoimmune conditions, often leading to an increased fracture risk. A 3D bicellular endo‐osteo microfluidic platform is developed to explore pathogenic mechanisms underlying GCs‐induced osteoporosis, highlighting a novel MAPK ...
Eun‐Jin Lee +10 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyBackgroundThe occurrence of pin loosening represents a common issue in the context of external fixation methodologies; nevertheless, a comprehensive investigation into the multifaceted causes of pin loosening, incorporating a multivariate analysis among ...
Yong-yi Huang +22 more
doaj +1 more source
Designing Fluid-Exuding Cartilage for Biomimetic Robots Mimicking Human Joint Lubrication Function [PDF]
The human joint is an open-type joint composed of bones, cartilage, ligaments, synovial fluid, and joint capsule, having advantages of flexibility and impact resistance. However, replicating this structure in robots introduces friction challenges due to the absence of bearings.
arxiv +1 more source
Advanced Healthcare Materials, EarlyView.Biomimetic glycosaminoglycan analog hydrogels exhibit suitable and robust mechanical properties, as well as hemocompatibility and biocompatibility, making them ideal for the embolization of intracranial aneurysms. Notably, the hydrogel's environment‐selective swelling properties enable complete blockage of the aneurysm cavity while preventing ...
Sarit S. Sivan +8 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This study developed 3D‐printable THA‐Col microgels for delivering BMP‐7 cmRNA. The key result is that hMSCs transfected on the biomaterials showed BMP‐7 secretion levels comparable to pre‐transfected hMSCs, therefore introducing a cmRNA‐activated matrix to promote bone healing.
Daphne van der Heide +7 more
wiley +1 more source
Improved diagnosis of tibiofemoral cartilage defects on MRI images using deep learning
Journal of Cartilage & Joint Preservation, 2021 Introduction: MRI is the modality of choice for cartilage imaging, however, its diagnostic performance is variable. Objectives: We aimed to evaluate whether deep learning can be utilized to accurately identify cartilage defects when applied to the ...
Gergo Merkely, M.D. +7 more
doaj
Pyrophosphate‐Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality
Advanced Healthcare Materials, EarlyView.The role of calcium pyrophosphate (Ca‐PP) in heterotopic bone formation and material degradation is investigated using calcium phosphate (CaP) compositions with varying Ca‐PP content. Results show that Ca‐PP does not impede heterotopic bone formation, minimally affects CaP degradation at non‐osseous sites, and increases phagocytosis.
Martina Jolic +7 more
wiley +1 more source
Carboxymethyl chitosan–zinc coating for prevention of pin tract infection: An animal model
Journal of Orthopaedic Surgery, 2018 Background: Pin tract infection is a common problem in orthopedic and traumatology surgery. The aim of this study was to investigate the efficacy of an implant coated with carboxymethyl chitosan–zinc (CMC-Zn 2+ ) in prevention of pin tract infection ...
Vidmi Taolam Martin +6 more
doaj +1 more source
Multi-Channel Volumetric Neural Network for Knee Cartilage Segmentation in Cone-beam CT [PDF]
, 2019 Analyzing knee cartilage thickness and strain under load can help to further the understanding of the effects of diseases like Osteoarthritis. A precise segmentation of the cartilage is a necessary prerequisite for this analysis. This segmentation task has mainly been addressed in Magnetic Resonance Imaging, and was rarely investigated on contrast ...
arxiv +1 more source
Advanced Healthcare Materials, EarlyView.This study presents the development of large‐scale (15 cm2) cartilage constructs with anisotropic mechanical properties using melt electrowritten (MEW) microfiber reinforced cell‐laden gelatin methacryloyl (gelMA). These constructs mimic the mechanical behavior of native cartilage, providing a suitable environment for Articular Cartilage ...
Lennard Spauwen +5 more
wiley +1 more source