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Biochemistry of articular cartilage in health and disease
Clinical Biochemistry, 1992Articular cartilage covers the ends of long bones in synovial joints, providing smooth articulation and cushioning of the underlying bone during joint movement. The tissue can be viewed as a viscoelastic, composite material composed of collagen type II (and smaller amounts of other collagens) entrapping compressed (underhydrated) proteoglycan ...
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Subchondral Bone and Cartilage Disease
Investigative Radiology, 2000The role of subchondral bone in the pathogenesis of cartilage damage has likely been underestimated. Subchondral bone is not only an important shock absorber, but it may also be important for cartilage metabolism. Contrary to many drawings and published reports, the subchondral region is highly vascularized and vulnerable. Its terminal vessels have, in
H, Imhof +5 more
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Calcification of Auricular Cartilage in Addison's Disease
Archives of Otolaryngology - Head and Neck Surgery, 1960A review of the literature on calcification of the auricular cartilage discloses that frostbite has, in the past, been believed to be the most common etiologic agent. Thus, Childrey 1 in 1938 reported on 61 cases presented by 21 observers. Other less common causes put forth at this time were (a) syphilis and (b) trauma with resulting perichondritis ...
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The pathophysiology of cartilage diseases.
Ortopedia, traumatologia, rehabilitacja, 2012Treatment of traumatic or degenerative defects of articular cartilage is a well-known problem for surgeons. Temporary or permanent disablement and high cost are due to diseases of the cartilage and bone. The articular cartilage is considered a tissue without the capacity to repair so that the "mechanical wear" of joint tissues is often designated as a ...
J, Steinhagen +3 more
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The role of neuropilin in bone/cartilage diseases
Life SciencesBone remodeling is the balance between osteoblasts and osteoclasts. Bone diseases such as osteoporosis and osteoarthritis are associated with imbalanced bone remodeling. Skeletal injury leads to limited motor function and pain. Neurophilin was initially identified in axons, and its various ligands and roles in bone remodeling, angiogenesis, neuropathic
Zuping, Wu +4 more
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The role of CXCL10 in cartilage development and diseases
CytokineCXC motif chemokine ligand 10 (CXCL10), also known as interferon γ-induced protein 10 kDa, is a pleiotropic member of the CXC chemokine family and plays a potent role in cellular functions and pathophysiological processes, which include but are not limited to recruitment of immune cells, induction of cellular apoptosis, regulation of cell growth and ...
Xi, Cao +3 more
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Adiponectin Interactions in Bone and Cartilage Biology and Disease
2012The adipokine adiponectin promotes insulin sensitivity and fat β-oxidation. In addition to its metabolic effects, adiponectin is an important local and systemic modulator of bone remodeling and cartilage biology, involving direct and indirect mechanisms and a large set of downstream molecular signals.
M. Ruscica, L. Steffani, P. Magni
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Degenerative joint disease: cartilage or vascular disease?
Skeletal Radiology, 1997The aetiology of degenerative joint disease is multifactorial, but one main cause is overloading (mechanical stress). While until recently it was well accepted that this represented primarily a disorder of cartilage with reactive subchondral changes, there is now some evidence that it might be primarily a subchondral problem with secondary changes in ...
H, Imhof +3 more
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Diagnosis of Bone and Cartilage Diseases
2012The aim of this chapter is to review the application of vibrational spectroscopy and microspectroscopy, namely FTIR and Raman spectroscopy and microspectroscopy in the diagnosis of drug- or disease-induced bone and cartilage disorders. The first section gives an introduction on the structure and composition as well as diseases of bone and cartilage and
Garip Sebnem, Boskey Adele L.
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Matrilins family and cartilage diseases
Precision Medicine, 2018Matrilins are cartilage abandon molecules which are a 4 member of family of non-collagen filamentous network proteins. In cartilage, extracellular matrix (ECM) occupied 95% space which determines the histoarchitecture specific to organ plays dominant role in chondrocyte functions.
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