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Epigenetics of cartilage diseases
Joint Bone Spine, 2016Osteoarticular diseases, such as arthritis or osteoarthritis, are multifactorial diseases with an underlying genetic etiology that are challenging to study. Genome-Wide Association studies (GWAS) have identified several genetic loci associated with these diseases.
Odile Gabay, Kathleen A Clouse
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Cartilage Oligomeric Matrix Protein, Diseases, and Therapeutic Opportunities
International Journal of Molecular Sciences, 2022 Cartilage oligomeric matrix protein (COMP) is an extracellular matrix (ECM) glycoprotein that is critical for collagen assembly and ECM stability. Mutations of COMP cause endoplasmic reticulum stress and chondrocyte apoptosis, resulting in rare skeleton ...
Jiarui Cui, Jiaming Zhang, Cui Jiarui
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Inflammatory Diseases of Cartilage
1991Inflammatory diseases of cartilage are relatively uncommon but are occasionally encountered by dermatologists. There is often a traumatic component, whether dramatic as in a cauliflower ear or subtle as in chondrodermatitis nodularis helicis. The ears are exposed and very susceptible to cold injury.
Otto Braun-Falco +3 more
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Respiratory chain inactivation links cartilage-mediated growth retardation to mitochondrial diseases
Journal of Cell Biology, 2019 International audienceIn childhood, skeletal growth is driven by transient expansion of cartilage in the growth plate. The common belief is that energy production in this hypoxic tissue mainly relies on anaerobic glycolysis and not on mitochondrial ...
Julia Etich +2 more
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Magnetic Resonance Imaging of Articular Cartilage and Evaluation of Cartilage Disease
Investigative Radiology, 2000Clinical magnetic resonance imaging of articular cartilage is possible by using techniques that offer high contrast between articular cartilage and adjacent structures in reasonable examination times. The fat-suppressed, three-dimensional, spoiled gradient-echo sequence has been reported to be accurate and reliable, and the addition of this sequence to
S, Trattnig +5 more
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Role of Epigenomics in Bone and Cartilage Disease
Journal of Bone and Mineral Research, 2019ABSTRACT Phenotypic variation in skeletal traits and diseases is the product of genetic and environmental factors. Epigenetic mechanisms include information-containing factors, other than DNA sequence, that cause stable changes in gene expression and are maintained during cell divisions.
van Meurs, Joyce +3 more
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