Results 31 to 40 of about 108,199 (280)

Effect on mechanical properties of articular cartilage through inflammatory response of synoviocytes under tissue and cell co-culture model

open access: yesNihon Kikai Gakkai ronbunshu, 2014
Articular cartilage has a poor ability to regenerate itself, therefore it is important to establish the treatment methodologies for cartilage diseases such as osteoarthritis (OA) or rheumatoid arthritis (RA).
Shinya YAMAZAKI, Shogo MIYATA
doaj   +1 more source

Roles of the calcified cartilage layer and its tissue engineering reconstruction in osteoarthritis treatment

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
Sandwiched between articular cartilage and subchondral bone, the calcified cartilage layer (CCL) takes on both biomechanical and biochemical functions in joint development and ordinary activities.
Weiyang Wang   +11 more
doaj   +1 more source

lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration

open access: yesStem Cell Research & Therapy, 2019
With the increasing incidence of cartilage-related diseases such as osteoarthritis (OA) and intervertebral disc degeneration (IDD), heavier financial and social burdens need to be faced.
Jian Zhu   +10 more
doaj   +1 more source

microRNAs in Cartilage Development, Homeostasis, and Disease [PDF]

open access: yesCurrent Osteoporosis Reports, 2014
microRNAs (miRNAs) regulate gene expression mainly at the posttranscriptional level. Many different miRNAs are expressed in chondrocytes, and each individual miRNA can regulate hundreds of target genes, creating a complex gene regulatory network.
Fatemeh, Mirzamohammadi   +2 more
openaire   +2 more sources

Cartilage homeostasis in health and rheumatic diseases [PDF]

open access: yesArthritis Research & Therapy, 2009
As the cellular component of articular cartilage, chondrocytes are responsible for maintaining in a low-turnover state the unique composition and organization of the matrix that was determined during embryonic and postnatal development. In joint diseases, cartilage homeostasis is disrupted by mechanisms that are driven by combinations of biological ...
Goldring, Mary B, Marcu, Kenneth B
openaire   +2 more sources

Raman spectroscopic insight into osteoarthritic cartilage regeneration by mRNA therapeutics encoding cartilage-anabolic transcription factor Runx1

open access: yesMaterials Today Bio, 2022
While joint arthroplasty remains nowadays the most popular option available to repair chronically degenerated osteoarthritic joints, possibilities are recently emerging for regeneration of damaged cartilage rather than its replacement with artificial ...
Giuseppe Pezzotti   +6 more
doaj   +1 more source

Mesenchymal stem cells for cartilage regeneration

open access: yesJournal of Tissue Engineering, 2020
Cartilage injuries are typically caused by trauma, chronic overload, and autoimmune diseases. Owing to the avascular structure and low metabolic activities of chondrocytes, cartilage generally does not self-repair following an injury. Currently, clinical
Hanxiang Le   +5 more
doaj   +1 more source

Investigation of the Effect of Selected Piperazine-2,5-Diones on Cartilage-Related Cells

open access: yesChemistry Proceedings, 2021
Various chronic inflammatory diseases have become a problem, especially in the Western world. Whether it concerns inflammation of visceral organs, joints, bones, etc., it is always a physiological reaction of the body, which always tries to eradicate ...
Josef Jampilek, Jan Hosek, Pavel Bobal
doaj   +1 more source

Knee Crepitus and Osteoarthritis Features in Young Adults Following Traumatic Knee Injury

open access: yesArthritis Care &Research, EarlyView.
Objective This study explored the association between knee crepitus and the presence, and worsening, of structural osteoarthritis features and self‐reported outcomes in young adults following traumatic knee injury. Methods One year following anterior cruciate ligament reconstruction (ACLR), 112 participants (41 female participants; median age 28 years ...
Jamon L. Couch   +8 more
wiley   +1 more source

Industrial application of fish cartilaginous tissues

open access: yesCurrent Research in Food Science, 2022
Cartilage is primarily composed of proteoglycans and collagen. Bioactive compounds derived from animal cartilage, such as chondroitin sulfate and type II collagen, have multiple bioactivities and are incorporated in popular health products.
Wen Li, Kazuhiro Ura, Yasuaki Takagi
doaj   +1 more source

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