Results 81 to 90 of about 136,745 (341)

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

Surgical Treatment of Articular Cartilage Defects in the Knee: Are We Winning?

Advances in Orthopedics, 2012
Articular cartilage (AC) injury is a common disorder. Numerous techniques have been employed to repair or regenerate the cartilage defects with varying degrees of success.
A. R. Memon, J. F. Quinlan
doaj   +1 more source

Cartilage repair in the hip

Annals of Joint, 2018
As techniques in hip arthroscopy advance, many of the joint preservation procedures previously limited to use in the knee are now being applied to the hip. Unlike the knee, chondral lesions in the hip rarely occur in isolation and are treated alongside correction of other pathologies, such as femoroacetabular impingement (FAI).
Ivan Wong, Erin E. Gordey
openaire   +2 more sources

The chondro-osseous continuum: is it possible to unlock the potential assigned within? [PDF]

, 2018
Endochondral ossification (EO), by which long bones of the axial skeleton form, is a tightly regulated process involving chondrocyte maturation with successive stages of proliferation, maturation, and hypertrophy, accompanied by cartilage matrix ...
Adams, Aizawa, Akintoye, Amling, Bahney, Ballock, Behonick, Boegård, Brachet, Cancedda, Candeliere, Carames, Clarkin, Colnot, Colnot, Day, Dodds, Emons, Enishi, Erenpreisa, Farnum, Farnum, Felson, Galotto, Gebhard, Gerstenfeld, Gibson, Gibson, Hall, Holmbeck, Hu, Hughes, Hunter, Javaheri, Jing, Johnell, Karaplis, Kawaguchi, Kuttapitiya, Lavigne, Lian, Lieu, Mackie, Maeda, Maes, Maes, Marigo, Moskalewski, Murphy, Ono, Ortega, Park, Pottenger, Poulet, Provot, Rawlinson, Riminucci, Roach, Roach, Roach, Shah, Shapiro, Silbermann, Song, Stafford, Stickens, Thesingh, Tsang, Van der Stricht, Vortkamp, Vu, Wade-Gueye, Wang, Woolf, Yang, Yoshioka, Zelzer, Zenmyo, Zhou, Zhou   +79 more
core   +3 more sources

Salt‐Compact Albumin as a New Pure Protein‐based Biomaterials: From Design to In Vivo Studies

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
A new class of materials built entirely of native albumin protein is designed using a simple protocol based on salt‐assisted compaction, breaking with current crosslinking strategies. This green process leads, surprisingly, to water‐insoluble handable materials with high preservation of their native protein structures and Young's modulus close to that ...
Eya Aloui, Jordan Beurton, Claire Medemblik, Ludivine Hugoni, Igor Clarot, Ariane Boudier, Youri Arntz, Marcella De Giorgi, Jérôme Combet, Guillaume Fleith, Eric Mathieu, Naji Kharouf, Leyla Kocgozlu, Benoît Heinrich, Damien Favier, Michael Brender, Fouzia Boulmedais, Pierre Schaaf, Benoît Frisch, Philippe Lavalle   +19 more
wiley   +1 more source

Mesenchymal stem cells for management of rheumatoid arthritis : immune modulation, repair or both? [PDF]

, 2018
The authors are grateful for support to their research from Arthritis Research UK (grants 19271, 19429, 19667, 20050, 20775) and the Medical Research Council (grant no.
Ansboro, Sharon, de Bari, Cosimo, Roelofs, Anke J.   +2 more
core   +1 more source

Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Osteoporosis induced by Glucocorticoids (GCs) is a common complication of long‐term GC use in patients with inflammatory and autoimmune conditions, often leading to an increased fracture risk. A 3D bicellular endo‐osteo microfluidic platform is developed to explore pathogenic mechanisms underlying GCs‐induced osteoporosis, highlighting a novel MAPK ...
Eun‐Jin Lee, Peter Lialios, Micaila Curtis, James Williams IV, Yoontae Kim, Paul Salipante, Steven Hudson, Mandy B. Esch, Moshe Levi, Joanna Kitlinska, Stella Alimperti   +10 more
wiley   +1 more source

Quantitative ultrasound biomicroscopy for the analysis of healthy and repair cartilage tissue [PDF]

European Cells & Materials, 2010
The increasing spectrum of different cartilage repair strategies requires the introduction of adequate non-destructive methods to analyse their outcome in-vivo, i.e. arthroscopically. The validity of non-destructive quantitative ultrasound biomicroscopy (
K Gelse, A Olk, S Eichhorn, B Swoboda, M Schoene, K Raum   +5 more
doaj  

Current and Novel Therapeutics for Articular Cartilage Repair and Regeneration

Therapeutics and Clinical Risk Management, 2023
Bo Cong,1,2 Tao Sun,1,2 Yuchi Zhao,1,2 Mingqi Chen1 1Department of Orthopedics, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, 264003, People’s Republic of China; 2Yantai Key Laboratory for Repair and Reconstruction of Bone & Joint,
Cong B, Sun T, Zhao Y, Chen M
doaj  

Subchondral drilling for articular cartilage repair: a systematic review of translational research

Disease Models & Mechanisms, 2018
Articular cartilage defects may initiate osteoarthritis. Subchondral drilling, a widely applied clinical technique to treat small cartilage defects, does not yield cartilage regeneration.
Liang Gao, Lars K. H. Goebel, Patrick Orth, Magali Cucchiarini, Henning Madry   +4 more
doaj   +1 more source