Results 61 to 70 of about 148,666 (361)

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Quality Evaluation of Human Bone Marrow Mesenchymal Stem Cells for Cartilage Repair

Stem Cells International, 2017
Quality evaluation of mesenchymal stem cells (MSCs) based on efficacy would be helpful for their clinical application. In this study, we aimed to find the factors of human bone marrow MSCs relating to cartilage repair.
Katsunori Shiraishi, Naosuke Kamei, Shunsuke Takeuchi, Shinobu Yanada, Hisashi Mera, Shigeyuki Wakitani, Nobuo Adachi, Mitsuo Ochi   +7 more
doaj   +1 more source

Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway [PDF]

, 2020
We previously established that DNA methyltransferase 3b (Dnmt3b) is the sole Dnmt responsive to fracture repair and that Dnmt3b expression is induced in progenitor cells during fracture repair.
Abu-Amer, Yousef, Guan, Jianjun, Jin, Hongting, O\u27Keefe, Regis, Shen, Jie, Tong, Peijian, Wang, Cuicui, Xu, Taotao, Ying, Jun   +8 more
core   +1 more source

Multi‐Responsive Dendrimer‐Hyaluronic Acid Hydrogel With Lubricating and Immunoregulatory Functions for Synergistic Osteoarthritis Therapy

Advanced Functional Materials, EarlyView.
A hydrogel with dynamic cross‐links was formed by cross‐linking hyaluronic acid with curcumin‐preloaded, phenylboronic acid‐modified poly(amidoamine) dendrimers. This hydrogel exhibited excellent injectability and self‐healing ability, enabling controlled Cur release in response to low pH, high reactive oxygen species (ROS) generation, or mechanical ...
Junjie Liu, Mengsi Zhan, Haoyu Huang, Jianhong Wang, Cheng Ni, Xiaojun Zhou, Hannah Küttner, Cong Song, Xiangyang Shi, Andrij Pich   +9 more
wiley   +1 more source

MACI Sandwich Technique With Autologous Bone Graft

Video Journal of Sports Medicine
Background: Osteochondral lesions of the knee are difficult to manage. Such lesions can be effectively treated with the matrix-induced autologous chondrocyte implantation (MACI) “sandwich” technique using autologous chondrocytes on porcine collagen ...
Tom Minas MD, MS
doaj   +1 more source

Combination of osteochondral allograft transplantation and particulated juvenile articular cartilage to treat osteochondral defects leads to low failure rates after a minimum of 2-year follow-up

Journal of Cartilage & Joint Preservation
: Introduction: Osteochondral allograft (OCA) transplantation effectively treats osteochondral defects using circular dowels. However, covering large or irregular defects with single plugs or two plug techniques sacrifices normal cartilage.
Gergo Merkely, Chilan B.G. Leite, Christos Papavassiliou, Alec Reihl, Jakob Ackermann, Christian Lattermann, Andreas H. Gomoll   +6 more
doaj   +1 more source

Assembly of Cell‐Seeded 3D Printed Hydrogel Modules with Perfusable Channel Networks

Advanced Functional Materials, EarlyView.
Macroscale assembly was utilized to prepare perfusable tissue constructs from individually 3D printed hydrogel modules with embedded branched channel networks and port arrays for cell seeding. Novel multi‐material bioreactors were fabricated to facilitate the gluing of individual modules and the perfusion culture of assembled modular constructs seeded ...
Zachary J. Geffert, Daniel Fougnier, Bo Van Durme, Jenna Grutzmacher, Ryan Clarke, Susan Cao, Zhenghao Li, Ujjwal Aryal, Jason A. Horton, Sandra Van Vlierberghe, Pranav Soman   +10 more
wiley   +1 more source

High-precision bioactive scaffold with dECM and extracellular vesicles targeting 4E-BP inhibition for cartilage injury repair

Materials Today Bio
The restoration of cartilage injuries remains a formidable challenge in orthopedics, chiefly attributed to the absence of vascularization and innervation in cartilage. Decellularized extracellular matrix (dECM) derived from cartilage, following antigenic
Yu Han, Yixin Dong, Bo Jia, Xiangyu Shi, Hongbo Zhao, Shushan Li, Haitao Wang, Binbin Sun, Li Yin, Kerong Dai   +9 more
doaj   +1 more source

Arthroscopic Minced Cartilage Implantation (MCI): A Technical Note

Arthroscopy Techniques, 2021
Articular cartilage lesions are identified with increasing frequency. Several cartilage repair techniques are available to treat symptomatic cartilage defects.
Stefan Schneider, M.D., Robert Ossendorff, M.D., Johannes Holz, M.D., Gian M. Salzmann, M.D., Ph.D.   +3 more
doaj   +1 more source

A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair

Advanced Healthcare Materials, EarlyView.
An off‐the‐shelf decellularized porcine meniscus fibrocartilage graft (MEND) is engineered for pediatric tympanoplasty. Featuring a microchannel architecture that promotes host cell invasion, MEND rapidly closes tympanic membrane perforations and fully remodels in vivo, outperforming fascia and matching cartilage grafts while avoiding donor‐site ...
Paul M. Gehret, Ryan M. Friedman, Gautham Nair, Stephanie L. Fung, Dana D. Ragbirsingh, John Germiller, Riccardo Gottardi   +6 more
wiley   +1 more source