Results 51 to 60 of about 148,666 (361)

Bone marrow cells immunomagnetically selected for CD271+ antigen promote in vitro the repair of articular cartilage defects [PDF]

, 2011
[Abstract] Objective: The purposes of this project were to quantify the cells expressing the mesenchymal stem cell (MSC) marker CD271 in synovial membranes from human osteoarthritic (OA) and healthy joints, and to determine if those CD271 cells were ...
Blanco García, Francisco J, De-Toro, Javier, Díaz-Prado, Silvia, Fuentes Boquete, Isaac Manuel, Gimeno-Longas, María José, Hermida Gómez, Tamara, Muíños-López, Emma   +6 more
core   +2 more sources

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused Approach

Gels, 2021
Stem cells hold tremendous promise for the treatment of cartilage repair in osteoarthritis. In addition to their multipotency, stem cells possess immunomodulatory effects that can alleviate inflammation and enhance cartilage repair.
Yisi Liu, Meng Wang, Yixuan Luo, Qianyi Liang, Yin Yu, Fei Chen, Jun Yao   +6 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

The Application of Polysaccharide Biocomposites to Repair Cartilage Defects

International Journal of Polymer Science, 2014
Owing to own nature of articular cartilage, it almost has no self-healing ability once damaged. Despite lots of restore technologies having been raised in the past decades, no repair technology has smoothly substituted for damaged cartilage using ...
Feng Zhao, Wei He, Yueling Yan, Hongjuan Zhang, Guoping Zhang, Dehu Tian, Hongyang Gao   +6 more
doaj   +1 more source

Atsttrin Promotes Cartilage Repair Primarily Through TNFR2-Akt Pathway

Frontiers in Cell and Developmental Biology, 2020
BackgroundCartilage defects account for substantial economic and humanistic burdens and pose a significant clinical problem. The efficacy of clinical approaches to cartilage repair is often inadequate, in part, owing to the restricted proliferative ...
Jianlu Wei, Jianlu Wei, Kaidi Wang, Aubryanna Hettinghouse, Chuanju Liu, Chuanju Liu   +5 more
doaj   +1 more source

Intraarticular injection of SHP2 inhibitor SHP099 promotes the repair of rabbit full-thickness cartilage defect

Journal of Orthopaedic Translation, 2022
Background: Cartilage repair has been a challenge in the field of orthopaedics for decades, highlighting the significance of investigating potential therapeutic drugs.
Ziying Sun, Xingquan Xu, Zhongyang Lv, Jiawei Li, Tianshu Shi, Heng Sun, Kuoyang Sun, Guihua Tan, Wenqiang Yan, Yannick Xiaofan Yang, Rui Wu, Jia Xu, Hu Guo, Qing Jiang, Dongquan Shi   +14 more
doaj   +1 more source

Platelet autologous growth factors decrease the osteochondral regeneration capability of a collagen-hydroxyapatite scaffold in a sheep model [PDF]

, 2010
Current research aims to develop innovative approaches to improve chondral and osteochondral regeneration. The objective of this study was to investigate the regenerative potential of platelet-rich plasma (PRP) to enhance the repair process of a collagen-
Kon, Elizaveta, Filardo, Giuseppe, Delcogliano, Marco, Fini, Milena, Salamanna, Francesca, Giavaresi, Gianluca, Martin, Ivan, Marcacci, Maurilio   +7 more
core   +1 more source

In Situ 3D Bioprinting: Impact of Cross‐Linking on the Adhesive Properties of Hydrogels

Advanced Functional Materials, EarlyView.
In situ 3D bioprinting enables the direct deposition of cell‐laden, adhesive biomaterials for on‐site tissue regeneration. This review provides a comprehensive overview of how cross‐linking influences the bioadhesive properties of hydrogels used in 3D bioprinting, highlighting cross‐linking triggers, bioadhesion mechanisms, polymer interpenetration ...
Odile Romero Fernandez, Mulazim Hussain Asim, Shumaila Arshad, Gergely Kali, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Nanostructured 3D Constructs Based on Chitosan and Chondroitin Sulphate Multilayers for Cartilage Tissue Engineering [PDF]

, 2013
Nanostructured three-dimensional constructs combining layer-by-layer technology (LbL) and template leaching were processed and evaluated as possible support structures for cartilage tissue engineering.
AM Martins, AR Fajardo, BC Heng, C Albrecht, C Chung, C Detzel, C Kirkpatrick, C Vinatier, Clemens A. Van Blitterswijk, D Puppi, E Miranda, EJ Menzel, FH Chen, FT Moutos, GV Martins, H Fan, J Almodo?var, JF Mano, JF Mano, JF Piai, JK Francis Suh, JM Sobral, JM Varghese, Joana M. Silva, João F. Mano, JRE Fraser, JS Mao, JS Pieper, JS Temenoff, K Anselme, K Köhler, K Von Der Mark, L Wu, L-P Yan, L-P Yan, M Kubo, Marcel Karperien, MV Voinova, Mário A. Barbosa, Nicole Georgi, NM Alves, O Franke, P Sher, Praveen Sher, R Jin, R Servaty, RG LeBaron, RR Costa, RR Costa, Rui Costa, Rui L. Reis, S Chatterjee, S Ghosh, S-H Lee, SC Neves, T Boudou, T Crouzier, W Sui, W-C Chen, WH Dietmar, Y Gong, Y Liu, Z Tang   +62 more
core   +4 more sources