Results 41 to 50 of about 75,319 (266)

A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair

Advanced Healthcare Materials, EarlyView.
An off‐the‐shelf decellularized porcine meniscus fibrocartilage graft (MEND) is engineered for pediatric tympanoplasty. Featuring a microchannel architecture that promotes host cell invasion, MEND rapidly closes tympanic membrane perforations and fully remodels in vivo, outperforming fascia and matching cartilage grafts while avoiding donor‐site ...
Paul M. Gehret, Ryan M. Friedman, Gautham Nair, Stephanie L. Fung, Dana D. Ragbirsingh, John Germiller, Riccardo Gottardi   +6 more
wiley   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Quality Evaluation of Human Bone Marrow Mesenchymal Stem Cells for Cartilage Repair

Stem Cells International, 2017
Quality evaluation of mesenchymal stem cells (MSCs) based on efficacy would be helpful for their clinical application. In this study, we aimed to find the factors of human bone marrow MSCs relating to cartilage repair.
Katsunori Shiraishi, Naosuke Kamei, Shunsuke Takeuchi, Shinobu Yanada, Hisashi Mera, Shigeyuki Wakitani, Nobuo Adachi, Mitsuo Ochi   +7 more
doaj   +1 more source

Coaxially Electrospun Myocardial dECM‐ Based Nanofibrous Scaffolds Demonstrate Enhanced Cardiomyocyte Biocompatibility

Advanced Healthcare Materials, EarlyView.
Our coaxial electrospinning system is capable of incorporating decellularized myocardial extracellular matrix in a core‐sheath configuration, creating nanofibrous scaffolds. These scaffolds, in turn, support the maintenance of functional cardiomyocytes adhered to the surface of these bioactive scaffolds.
Dhanusha N. Rajapakse, Mahtab Khodadadi, Kiran M. Ali, Suh Hee Cook, Bryson T. Proctor, Tanya Upadhyay, Daxian Zha, Fatema Tuj Jahura, Marziyeh Boosaliki, Jessica M. Gluck   +9 more
wiley   +1 more source

MACI Sandwich Technique With Autologous Bone Graft

Video Journal of Sports Medicine
Background: Osteochondral lesions of the knee are difficult to manage. Such lesions can be effectively treated with the matrix-induced autologous chondrocyte implantation (MACI) “sandwich” technique using autologous chondrocytes on porcine collagen ...
Tom Minas MD, MS
doaj   +1 more source

High-precision bioactive scaffold with dECM and extracellular vesicles targeting 4E-BP inhibition for cartilage injury repair

Materials Today Bio
The restoration of cartilage injuries remains a formidable challenge in orthopedics, chiefly attributed to the absence of vascularization and innervation in cartilage. Decellularized extracellular matrix (dECM) derived from cartilage, following antigenic
Yu Han, Yixin Dong, Bo Jia, Xiangyu Shi, Hongbo Zhao, Shushan Li, Haitao Wang, Binbin Sun, Li Yin, Kerong Dai   +9 more
doaj   +1 more source

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

Combination of osteochondral allograft transplantation and particulated juvenile articular cartilage to treat osteochondral defects leads to low failure rates after a minimum of 2-year follow-up

Journal of Cartilage & Joint Preservation
: Introduction: Osteochondral allograft (OCA) transplantation effectively treats osteochondral defects using circular dowels. However, covering large or irregular defects with single plugs or two plug techniques sacrifices normal cartilage.
Gergo Merkely, Chilan B.G. Leite, Christos Papavassiliou, Alec Reihl, Jakob Ackermann, Christian Lattermann, Andreas H. Gomoll   +6 more
doaj   +1 more source

Biomechanics of integrative cartilage repair

Osteoarthritis and Cartilage, 1999
Cartilage repair is required in a number of orthopaedic conditions and rheumatic diseases. From a macroscopic viewpoint, the complete repair of an articular cartilage defect requires integration of opposing cartilage surfaces or the integration of repair tissue with the surrounding host cartilage.
Ahsan, Tabassum, Sah, Robert L.
openaire   +2 more sources

Gene Therapy for Cartilage Repair [PDF]

CARTILAGE, 2011
The concept of using gene transfer strategies for cartilage repair originates from the idea of transferring genes encoding therapeutic factors into the repair tissue, resulting in a temporarily and spatially defined delivery of therapeutic molecules to sites of cartilage damage.
Madry, Henning, Orth, Patrick, Cucchiarini, Magali   +2 more
openaire   +2 more sources