Results 31 to 40 of about 75,319 (266)
Bridging Suture Repair for Acetabular Chondral Carpet Delamination
Arthroscopy Techniques, 2015 Acetabular chondral carpet delamination is a frequent finding at hip arthroscopy. The cartilage is macroscopically normal but deboned from the subchondral bone, without a disruption at the chondrolabral junction.
Mitsunori Kaya, M.D. +2 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Deer antler reserve mesenchyme cells with hyaluronan alleviates cartilage damage in a rat model
Animal Research and One Health, 2023 Reserve mesenchyme cells (RMCs) of deer antlers have been considered as the promising cell source for repairing injury‐induced articular cartilage or cartilage degeneration.
Boyin Jia +15 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier +12 more
wiley +1 more source
Atsttrin Promotes Cartilage Repair Primarily Through TNFR2-Akt Pathway
Frontiers in Cell and Developmental Biology, 2020 BackgroundCartilage defects account for substantial economic and humanistic burdens and pose a significant clinical problem. The efficacy of clinical approaches to cartilage repair is often inadequate, in part, owing to the restricted proliferative ...
Jianlu Wei +5 more
doaj +1 more source
Journal of Orthopaedic Translation, 2022 Background: Cartilage repair has been a challenge in the field of orthopaedics for decades, highlighting the significance of investigating potential therapeutic drugs.
Ziying Sun +14 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim +9 more
wiley +1 more source
The Application of Polysaccharide Biocomposites to Repair Cartilage Defects
International Journal of Polymer Science, 2014 Owing to own nature of articular cartilage, it almost has no self-healing ability once damaged. Despite lots of restore technologies having been raised in the past decades, no repair technology has smoothly substituted for damaged cartilage using ...
Feng Zhao +6 more
doaj +1 more source
Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused Approach
Gels, 2021 Stem cells hold tremendous promise for the treatment of cartilage repair in osteoarthritis. In addition to their multipotency, stem cells possess immunomodulatory effects that can alleviate inflammation and enhance cartilage repair.
Yisi Liu +6 more
doaj +1 more source