Results 11 to 20 of about 78,680 (264)

O-alg-THAM/gel hydrogels functionalized with engineered microspheres based on mesenchymal stem cell secretion recruit endogenous stem cells for cartilage repair

Bioactive Materials, 2023
Lacking self-repair abilities, injuries to articular cartilage can lead to cartilage degeneration and ultimately result in osteoarthritis. Tissue engineering based on functional bioactive scaffolds are emerging as promising approaches for articular ...
Yucong Li, Linlong Li, Ming Wang, Boguang Yang, Baozhen Huang, Shanshan Bai, Xiaoting Zhang, Nan Hou, Haixing Wang, Zhengmeng Yang, Chong Tang, Ye Li, Wayne Yuk-Wai Lee, Lu Feng, Micky D. Tortorella, Gang Li   +15 more
doaj   +1 more source

Allogeneic Umbilical Cord-Blood-Derived Mesenchymal Stem Cells and Hyaluronate Composite Combined with High Tibial Osteotomy for Medial Knee Osteoarthritis with Full-Thickness Cartilage Defects

Medicina, 2023
Background and Objectives: Although the effects of cartilage repair in patients who are undergoing high tibial osteotomy (HTO) remains controversial, cartilage repair may be required for the full-thickness cartilage defect because of a concern of lower ...
Yong-Beom Park, Han-Jun Lee, Hyun-Cheul Nam, Jung-Gwan Park   +3 more
doaj   +1 more source

Matrix-Associated Chondroplasty: A Novel Platelet-Rich Plasma and Concentrated Nucleated Bone Marrow Cell–Enhanced Cartilage Restoration Technique

Arthroscopy Techniques, 2014
Bone marrow stimulation techniques such as microfracture for the treatment of articular cartilage defects so far solely reproduce mechanically inferior fibrous cartilage tissue, which might result in unsatisfactory clinical results at midterm.
Matthias R. Steinwachs, M.D., Bernhard Waibl, M.D., Stephanie Wopperer, M.D., Marcus Mumme, M.D.   +3 more
doaj   +1 more source

Arthroscopic Treatment of Cartilage Lesions With Microfracture and BST-CarGel

Arthroscopy Techniques, 2014
Bone marrow stimulation techniques for the treatment of articular cartilage defects such as microfracture so far have solely reproduced mechanically inferior fibrous cartilage tissue, which might result in unsatisfactory clinical results at midterm ...
Matthias R. Steinwachs, M.D., Bernhard Waibl, M.D., Marcus Mumme, M.D.   +2 more
doaj   +1 more source

Liquid-Responsive Shape-Memory Nanofiber-Reinforced Scaffolds for Cartilage Repair. [PDF]

Adv Sci (Weinh)
A liquid‐responsive shape‐memory, nanofiber‐reinforced QCG scaffold combines conformal defect filling, an aligned architecture that is structurally permissive for endogenous cell infiltration, and sustained KGN release. This integrated design enhances BMSC viability, migratory activity, and chondrogenic differentiation and promotes hyaline cartilage ...
Zeng J, Li W, Li Y, Tu Z, Ma H, Dai Y, Ma Z, Yuan T, Wang B.   +8 more
europepmc   +2 more sources

Signaling Pathways in Cartilage Repair [PDF]

International Journal of Molecular Sciences, 2014
In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine balance between anabolic and catabolic activities. In ageing, degenerative joint diseases and traumatic injuries of cartilage, a loss of homeostatic conditions and an up-regulation of catabolic pathways occur.
MARIANI, ERMINIA, Pulsatelli, Lia, Facchini, Andrea   +2 more
openaire   +2 more sources

Biological Knee Reconstruction With Concomitant Autologous Chondrocyte Implantation and Meniscal Allograft Transplantation

Orthopaedic Journal of Sports Medicine, 2016
Background: Treating articular cartilage defects and meniscal deficiency is challenging. Although some short- to mid-term follow-up studies report good clinical outcomes after concurrent autologous chondrocyte implantation (ACI) and meniscal allograft ...
Takahiro Ogura MD, Tim Bryant BSN, RN, Tom Minas MD, MS   +2 more
doaj   +1 more source

Autologous Chondrocyte Implantation “Segmental-Sandwich” Technique for Deep Osteochondral Defects in the Knee: Clinical Outcomes and Correlation With Magnetic Resonance Imaging Findings

Orthopaedic Journal of Sports Medicine, 2019
Background: Symptomatic osteochondral defects are difficult to manage, especially in patients with deep (>8-10 mm) empty defects. The restoration of articular congruence is crucial to avoid the progression to osteoarthritis (OA). Purpose: To describe the
Takahiro Ogura MD, Gergo Merkely MD, Tim Bryant BSN, RN, Carl S. Winalski MD, Tom Minas MD, MS   +4 more
doaj   +1 more source

Intermediate- to Long-Term Results of Combined Anterior Cruciate Ligament Reconstruction and Autologous Chondrocyte Implantation

Orthopaedic Journal of Sports Medicine, 2017
Background: Cartilage injury associated with anterior cruciate ligament (ACL) ruptures is common; however, relatively few reports exist on concurrent cartilage repair with ACL reconstruction.
Andrew N. Pike MD, Tim Bryant RN, Takahiro Ogura MD, Tom Minas MD   +3 more
doaj   +1 more source

Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage. [PDF]

PLoS ONE, 2010
BackgroundArticular cartilage displays a poor repair capacity. The aim of cell-based therapies for cartilage defects is to repair damaged joint surfaces with a functional replacement tissue.
Rebecca Williams, Ilyas M Khan, Kirsty Richardson, Larissa Nelson, Helen E McCarthy, Talal Analbelsi, Sim K Singhrao, Gary P Dowthwaite, Rhiannon E Jones, Duncan M Baird, Holly Lewis, Selwyn Roberts, Hannah M Shaw, Jayesh Dudhia, John Fairclough, Timothy Briggs, Charles W Archer   +16 more
doaj   +1 more source